Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

Vasopressin deficiency: driver of social impairment and fluid imbalance in ASD? [pdf]

med.stanford.edu

Post reply on HN
Print view View original

61–70 of 106 posts

Re: Vasopressin deficiency: driver of social impairment and fluid imbalance in ASD? [pdf]

#61

Post by c0pium »

loceng wrote: post #54
Solvency wrote: post #37

Earlier quoted context omitted.

"...in mice."

Confirmed in mice, observed first anecdotally in children with autism. I'm blown away we still as a society don't have a system where all of this information is quickly accessible in a sorted way by various trusted organizations that follow specific protocols that people determine how trustworthy they are.

That would require us as a society to develop concrete solutions to determining who can be trusted. That’s obviously impossible, so we’re stuck with the process we have.

Re: Vasopressin deficiency: driver of social impairment and fluid imbalance in ASD? [pdf]

#62

Post by c0pium »

uranium wrote: post #44
polishdude20 wrote: post #17

Earlier quoted context omitted.

How would this be true for planes? They're constantly being fed fresh air from the engines during flight.

I carried a CO2 meter on a flight recently, to use CO2 as a proxy for COVID risk. The levels were quite high for the whole flight--over 1000 pretty much the whole time iirc and worse on the tarmac.

How did you calibrate the meter for the changing temperature and pressure? Most CO2 meter designs are extremely sensitive to pressure changes.

Re: Vasopressin deficiency: driver of social impairment and fluid imbalance in ASD? [pdf]

#63

Post by loceng »

c0pium wrote: post #61
loceng wrote: post #54

Earlier quoted context omitted.

Confirmed in mice, observed first anecdotally in children with autism. I'm blown away we still as a society don't have a system where all of this information is quickly accessible in a sorted way by various trusted organizations that follow specific protocols that people determine how trustworthy they are.

That would require us as a society to develop concrete solutions to determining who can be trusted. That’s obviously impossible, so we’re stuck with the process we have.

It's actually the individual's responsibility to develop an understanding of how one determines what is trustworthy and what isn't trustworthy, and they they do their best to develop that. For example, if someone lies, they are caught lying, the evidence is presented but a person doesn't care or put any weight on that someone lied - well, they are going to rank that person or an organization they are running or still party to.

I'd argue it's bad actors who don't want such a highly organized system that helps people discern easier, a sort of societal wide "fog of war" to make knowing closer towards the truth, the whole truth, and nothing but the truth - harder; with AI generated images and video coming, I don't know how society will cope with such a thing - where "video evidence" could exist painting a horrific reputation of someone to destroy them perhaps not only economically but perhaps also weaponizing a mob to kill someone.

Re: Vasopressin deficiency: driver of social impairment and fluid imbalance in ASD? [pdf]

#64

Post by grumpy-de-sre »

Now that's some serendipitous reading.

I've been on the hunt for possible mechanisms (for further study) as to why last year after trying an SSRI (escitalopram), to treat an anxiety disorder co-morbid to my ASD, that I ended up in the hospital in a hypertensive crisis. Was an all around terrible experience and I hope one day I can figure out WTF happened to me.

Interestingly the BP rise seemed to be mostly diastolic driven and I had crazy excessive urination which made me think about ADH/aldosterone/etc. Seeing ADH is potentially linked to ASD definitely catches my attention! Some of the alternative theories are, I am a MAO-A knockout (unlikely because of lack of intellectual disability), or possess a hyperfunctional SERT (also linked to ASD).

Really excited for the results of the whole genome sequencing I ordered to arrive.

Re: Vasopressin deficiency: driver of social impairment and fluid imbalance in ASD? [pdf]

#65

Post by c0pium »

tootie wrote: post #48
pc86 wrote: post #32

Earlier quoted context omitted.

Cars don't lead to increased indoor CO2 levels.

Yeah, I'm disagreeing with you. It's not CO2. I won't say it's impossible, but it's pretty implausible. We already know how bad leaded gasoline was at poisoning an entire generation. Modern cars are cleaner, but miles driven keeps increasing and the amount pollutants being emitted are poisoning people.

So cars=bad∴cars->ASD? Is that your argument?

Re: Vasopressin deficiency: driver of social impairment and fluid imbalance in ASD? [pdf]

#66

Post by colloydi »

c0pium wrote: post #59
zelphirkalt wrote: post #55

Earlier quoted context omitted.

(Gesundheit = Health)

Sometimes, and sometimes it’s a name. https://profiles.stanford.edu/neil-gesundheit

And very occasionally it's a serendipitous name!

Re: Vasopressin deficiency: driver of social impairment and fluid imbalance in ASD? [pdf]

#67

Post by naasking »

michaelrpeskin wrote: post #58
FrustratedMonky wrote: post #2

Doing quick search, there is also interactions between Vasopressin and salt and blood pressure. Could ASD be helped by reducing salt? or increasing salt? I'm not knowledgeable enough to untangle all of the studies where these terms are also used, which I guess is part of the problem this paper is pointing out, that the terminology/naming is confusing. Is this saying if you have blood pressure problems you might also…

> Could ASD be helped by reducing salt? or increasing salt? Personal story here (N=1, not claiming anything other than that). My dad is clearly ASD, and has battled high blood pressure for as long as I can remember. He's now suffering the consequences of 40 years of absolute salt avoidance. 1) I never saw and reduction in the ASD over the past 40 years, 2) lack of salt never changed his blood pressure, and 3) now he'…

Avoiding table salt thoroughly could potentially lead to iodine deficiency. It was somewhat common in the past so most table salt over the past century has had iodine added to it to avoid this, but it's cropping back up a bit as people avoid salt or prefer to use "natural rock salts" common in fine cuisine, which are not reinforced with iodine.

Re: Vasopressin deficiency: driver of social impairment and fluid imbalance in ASD? [pdf]

#68

Post by naasking »

Cheer2171 wrote: post #45
pc86 wrote: post #31

Earlier quoted context omitted.

ASD diagnoses have skyrocketed in the past few decades (years?) with no clear cause. I'm just old enough to remember a childhood without cell phones - we didn't have a computer in my house until middle school but we were lower income than most of my friends - and people are definitely inside more and outside less than they were when I was 8 or 9 years old. It seems like a plausible theory.

When left handedness was seen as a disorder and students who used their left hand were beaten, rates of this disorder were a few percent. When the idea of left handedness became mainstream, rates skyrocketed and we know the base rate is about 10%. Homosexuality was considered a disorder in the DSM until 1974. Self-reported rates of homosexuality have skyrocketed since then. Most likely explanation is that the true ba…

You think. Let's be clear about what's a hypothesis vs. a confirmed fact.

Re: Vasopressin deficiency: driver of social impairment and fluid imbalance in ASD? [pdf]

#69

Post by colloydi »

electrondood wrote: post #43
mchannon wrote: post #8

I’ve theorized in my book _Fat Gas_ that vasopressin levels are tied to elevated indoor CO2 levels. Would not be at all surprised if these novel social conditions stem from not going outside enough and from poorly ventilated buildings (especially gyms and conference rooms) and transport (planes trains and automobiles each routinely exceed 1000 ppm from everybody’s lungs).

If elevated CO2 increases vasopressin, and if increased vasopressin drives symptoms of autism, then wouldn't we see a large population with autism symptoms in the Midwest or anywhere that people are indoors all winter?

I think it's vasopressin deficiency that is claimed to drive those symptoms.

Re: Vasopressin deficiency: driver of social impairment and fluid imbalance in ASD? [pdf]

#70

Post by marginalia_nu »

colloydi wrote: post #66
c0pium wrote: post #59

Earlier quoted context omitted.

Sometimes, and sometimes it’s a name. https://profiles.stanford.edu/neil-gesundheit

And very occasionally it's a serendipitous name!

Nominative Determinism is a hell of a thing.
Post reply on HN