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Vasopressin deficiency: driver of social impairment and fluid imbalance in ASD? [pdf]

med.stanford.edu

51–60 of 106 posts

Re: Vasopressin deficiency: driver of social impairment and fluid imbalance in ASD? [pdf]

#51
post #33

Earlier quoted context omitted.

How would this be true for planes? They're constantly being fed fresh air from the engines during flight.

It's true for every other mode of transport but objectively false for planes in flight . However, I'd be curious to see the average when including time sitting on the ground, taxiing, etc., and how that much lower speed affects circulation.

The refreshed air in the cabin is driven by engine bleed air (or a dedicated pressure pump) so even at idle power there is nothing preventing a high rate of cabin air exchange. There might still be less air flowing on the ground due to 0 cabin air pressure differential, but speed of the plane isn't a relevant factor.

Re: Vasopressin deficiency: driver of social impairment and fluid imbalance in ASD? [pdf]

#52
post #31
post #25

Earlier quoted context omitted.

Could you elaborate on what you mean by "novel social conditions"?

ASD diagnoses have skyrocketed in the past few decades (years?) with no clear cause. I'm just old enough to remember a childhood without cell phones - we didn't have a computer in my house until middle school but we were lower income than most of my friends - and people are definitely inside more and outside less than they were when I was 8 or 9 years old. It seems like a plausible theory.

It doesn't seem plausible to me, based on my anecdotal experience with an ASD child who played in the woods all the time.

Re: Vasopressin deficiency: driver of social impairment and fluid imbalance in ASD? [pdf]

#53
post #22

Earlier quoted context omitted.

You’ll have lower CO2 levels in a dense urban housing with windows open, than in a home in the middle of nowhere with the windows closed. The issue isn’t the higher amount of CO2 in the ambient air in the cities (AIUI it is; marginally; but it doesn’t matter); it’s that CO2 is very good at concentrating in enclosed spaces.

literally only in the currently designed world dominated by large cars, which is equally outrageous. Nuke the entire nonsense system we have, let people have homes in yards, and force everyone to get around on bicycles and electric scooters and electric accessibility carts.

I'm confused; what changes to indoor CO2 levels do you think that would bring?

Re: Vasopressin deficiency: driver of social impairment and fluid imbalance in ASD? [pdf]

#54

Earlier quoted context omitted.

Google. https://hms.harvard.edu/news/cracking-fever-autism-mystery

"...in mice."

Confirmed in mice, observed first anecdotally in children with autism.

I'm blown away we still as a society don't have a system where all of this information is quickly accessible in a sorted way by various trusted organizations that follow specific protocols that people determine how trustworthy they are.

Re: Vasopressin deficiency: driver of social impairment and fluid imbalance in ASD? [pdf]

#55
post #4

Doing quick search, there is also interactions between Vasopressin and salt and blood pressure. Could ASD be helped by reducing salt? or increasing salt? I'm not knowledgeable enough to untangle all of the studies where these terms are also used, which I guess is part of the problem this paper is pointing out, that the terminology/naming is confusing. Is this saying if you have blood pressure problems you might also…

You’re almost there. It’s saying that you’re at risk for central diabetes insipidus known to cause abnormal thirst and urination in like the next paragraph. What I find hilarious is that the whole first paragraph is about things being named after scientists and then there’s an author named Gesundheit…now I need to look that up.

(Gesundheit = Health)

Re: Vasopressin deficiency: driver of social impairment and fluid imbalance in ASD? [pdf]

#56

Earlier quoted context omitted.

CO2 levels are high in enclosed spaces, not in urban environments

People who live in urban environments statistically spend less time outdoors.

Oddly, I've suspected the opposite. In my eyes, people who live in urban areas walk for transportation far more often than suburbanites.

Re: Vasopressin deficiency: driver of social impairment and fluid imbalance in ASD? [pdf]

#57
post #30

That’s a fascinating introduction - they are concerned that dual (!) name of the molecule might be hiding all of its functions! It looks like naming thing is not just a problem for programmers.

When I was diagnosed with a neurological condition that was having mostly physical symptoms, the first-line defense was antidepressants. So-named because they were developed to relieve depression, but really what they do is inhibit absorption of serotonin and/or norepinephrine leaving more free in the body to act on myriad different bodily functions. In my case, it actually caused serious digestion issues. It really…

Of course there will be lots of molecules involved, but that doesn't make it any easier to understand let alone do something about it. In medicine and especially in psychology our functioning is a huge black box with only indirect knowledge about interactions with certain things at a very high level.

Re: Vasopressin deficiency: driver of social impairment and fluid imbalance in ASD? [pdf]

#58

Doing quick search, there is also interactions between Vasopressin and salt and blood pressure. Could ASD be helped by reducing salt? or increasing salt? I'm not knowledgeable enough to untangle all of the studies where these terms are also used, which I guess is part of the problem this paper is pointing out, that the terminology/naming is confusing. Is this saying if you have blood pressure problems you might also…

> Could ASD be helped by reducing salt? or increasing salt?

Personal story here (N=1, not claiming anything other than that). My dad is clearly ASD, and has battled high blood pressure for as long as I can remember. He's now suffering the consequences of 40 years of absolute salt avoidance. 1) I never saw and reduction in the ASD over the past 40 years, 2) lack of salt never changed his blood pressure, and 3) now he's suffering other heath effects, but won't listen to me and only wants to do more of the same.

Re: Vasopressin deficiency: driver of social impairment and fluid imbalance in ASD? [pdf]

#59
post #4

Earlier quoted context omitted.

You’re almost there. It’s saying that you’re at risk for central diabetes insipidus known to cause abnormal thirst and urination in like the next paragraph. What I find hilarious is that the whole first paragraph is about things being named after scientists and then there’s an author named Gesundheit…now I need to look that up.

(Gesundheit = Health)

Sometimes, and sometimes it’s a name.

https://profiles.stanford.edu/neil-gesundheit

Re: Vasopressin deficiency: driver of social impairment and fluid imbalance in ASD? [pdf]

#60
post #7

Doing quick search, there is also interactions between Vasopressin and salt and blood pressure. Could ASD be helped by reducing salt? or increasing salt? I'm not knowledgeable enough to untangle all of the studies where these terms are also used, which I guess is part of the problem this paper is pointing out, that the terminology/naming is confusing. Is this saying if you have blood pressure problems you might also…

One thing I always found interesting is that inducing a fever in autistic people, in some of them it will reduce the severity of their autistic characteristics.

The one that weirds me out is that sleep deprivation can quite rapidly reduce depression, if only temporarily:

https://www.pennmedicine.org/news/news-releases/2017/septemb...

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