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Vasopressin deficiency: driver of social impairment and fluid imbalance in ASD? [pdf]

med.stanford.edu

41–50 of 106 posts

Re: Vasopressin deficiency: driver of social impairment and fluid imbalance in ASD? [pdf]

#41
post #8

I’ve theorized in my book _Fat Gas_ that vasopressin levels are tied to elevated indoor CO2 levels. Would not be at all surprised if these novel social conditions stem from not going outside enough and from poorly ventilated buildings (especially gyms and conference rooms) and transport (planes trains and automobiles each routinely exceed 1000 ppm from everybody’s lungs).

Vasopressin is tied to single-cell acid/base regulation, on that chromosome 3/7/17/X major axis.

Re: Vasopressin deficiency: driver of social impairment and fluid imbalance in ASD? [pdf]

#42
post #8

I’ve theorized in my book _Fat Gas_ that vasopressin levels are tied to elevated indoor CO2 levels. Would not be at all surprised if these novel social conditions stem from not going outside enough and from poorly ventilated buildings (especially gyms and conference rooms) and transport (planes trains and automobiles each routinely exceed 1000 ppm from everybody’s lungs).

This makes a LOT of sense explaining how wearing a mask throughout the day observably changes behavior!!

Re: Vasopressin deficiency: driver of social impairment and fluid imbalance in ASD? [pdf]

#43
post #8

I’ve theorized in my book _Fat Gas_ that vasopressin levels are tied to elevated indoor CO2 levels. Would not be at all surprised if these novel social conditions stem from not going outside enough and from poorly ventilated buildings (especially gyms and conference rooms) and transport (planes trains and automobiles each routinely exceed 1000 ppm from everybody’s lungs).

If elevated CO2 increases vasopressin, and if increased vasopressin drives symptoms of autism, then wouldn't we see a large population with autism symptoms in the Midwest or anywhere that people are indoors all winter?

Re: Vasopressin deficiency: driver of social impairment and fluid imbalance in ASD? [pdf]

#44
post #8

I’ve theorized in my book _Fat Gas_ that vasopressin levels are tied to elevated indoor CO2 levels. Would not be at all surprised if these novel social conditions stem from not going outside enough and from poorly ventilated buildings (especially gyms and conference rooms) and transport (planes trains and automobiles each routinely exceed 1000 ppm from everybody’s lungs).

How would this be true for planes? They're constantly being fed fresh air from the engines during flight.

I carried a CO2 meter on a flight recently, to use CO2 as a proxy for COVID risk. The levels were quite high for the whole flight--over 1000 pretty much the whole time iirc and worse on the tarmac.

Re: Vasopressin deficiency: driver of social impairment and fluid imbalance in ASD? [pdf]

#45
post #31
post #25

Earlier quoted context omitted.

Could you elaborate on what you mean by "novel social conditions"?

ASD diagnoses have skyrocketed in the past few decades (years?) with no clear cause. I'm just old enough to remember a childhood without cell phones - we didn't have a computer in my house until middle school but we were lower income than most of my friends - and people are definitely inside more and outside less than they were when I was 8 or 9 years old. It seems like a plausible theory.

When left handedness was seen as a disorder and students who used their left hand were beaten, rates of this disorder were a few percent. When the idea of left handedness became mainstream, rates skyrocketed and we know the base rate is about 10%.

Homosexuality was considered a disorder in the DSM until 1974. Self-reported rates of homosexuality have skyrocketed since then. Most likely explanation is that the true base rate has not changed, just society's measurement of it.

Children with ASD in prior generations were labeled as delinquent, troublemakers, retarded, or were abandoned by their parents and communities.

Re: Vasopressin deficiency: driver of social impairment and fluid imbalance in ASD? [pdf]

#46
post #30

That’s a fascinating introduction - they are concerned that dual (!) name of the molecule might be hiding all of its functions! It looks like naming thing is not just a problem for programmers.

When I was diagnosed with a neurological condition that was having mostly physical symptoms, the first-line defense was antidepressants. So-named because they were developed to relieve depression, but really what they do is inhibit absorption of serotonin and/or norepinephrine leaving more free in the body to act on myriad different bodily functions. In my case, it actually caused serious digestion issues. It really…

Yes! This! We are our bodies, and our bodies are biochemical. I'm encouraged by growing awareness and acceptance of things like psilocybin-based treatment for PTSD. Psychobiology is fundamental to... everything a human can experience or be.

Re: Vasopressin deficiency: driver of social impairment and fluid imbalance in ASD? [pdf]

#47
post #21
post #18

Earlier quoted context omitted.

What do you change about your lifestyle with that test result? I have a child with ASD, and also drinks mad amounts of water. But I didn't see any treatment plan if this deficiency is confirmed.

Find a clinical trial, perhaps? There seems to be a bit of study in this direction: https://med.stanford.edu/news/all-news/2019/05/hormone-reduc...

Thank you for this link!

Re: Vasopressin deficiency: driver of social impairment and fluid imbalance in ASD? [pdf]

#48
post #32
post #14

Earlier quoted context omitted.

I mean, it's cars. Fossil fuel combustion in general, but car exhaust in particular.

Cars don't lead to increased indoor CO2 levels.

Yeah, I'm disagreeing with you. It's not CO2. I won't say it's impossible, but it's pretty implausible. We already know how bad leaded gasoline was at poisoning an entire generation. Modern cars are cleaner, but miles driven keeps increasing and the amount pollutants being emitted are poisoning people.

Re: Vasopressin deficiency: driver of social impairment and fluid imbalance in ASD? [pdf]

#49
post #18

Earlier quoted context omitted.

What do you change about your lifestyle with that test result? I have a child with ASD, and also drinks mad amounts of water. But I didn't see any treatment plan if this deficiency is confirmed.

Essentially if this theory is accurate it kind of shares similar patterns to diabetes insipidus which is essentially vasopressin dysfunction. So you can Google that and see how that is treated and tested for.

Thanks

Re: Vasopressin deficiency: driver of social impairment and fluid imbalance in ASD? [pdf]

#50
post #8

I’ve theorized in my book _Fat Gas_ that vasopressin levels are tied to elevated indoor CO2 levels. Would not be at all surprised if these novel social conditions stem from not going outside enough and from poorly ventilated buildings (especially gyms and conference rooms) and transport (planes trains and automobiles each routinely exceed 1000 ppm from everybody’s lungs).

My nephew is on the spectrum (fairly severely). His mother and father are obsessed with air quality and used filtration and forced ERVs for the entire pregnancy and upbringing. Please do not make such strong medical claims without any scientific backing, it is quite harmful to kids with autism and their parents who are already overwhelmed with quackery.
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