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Vasopressin deficiency: driver of social impairment and fluid imbalance in ASD? [pdf]

med.stanford.edu

21–30 of 106 posts

Re: Vasopressin deficiency: driver of social impairment and fluid imbalance in ASD? [pdf]

#21
post #18

You can get tested for this if you have ASD by getting a copeptin test.

What do you change about your lifestyle with that test result? I have a child with ASD, and also drinks mad amounts of water. But I didn't see any treatment plan if this deficiency is confirmed.

Find a clinical trial, perhaps? There seems to be a bit of study in this direction:

https://med.stanford.edu/news/all-news/2019/05/hormone-reduc...

Re: Vasopressin deficiency: driver of social impairment and fluid imbalance in ASD? [pdf]

#22
post #8

I’ve theorized in my book _Fat Gas_ that vasopressin levels are tied to elevated indoor CO2 levels. Would not be at all surprised if these novel social conditions stem from not going outside enough and from poorly ventilated buildings (especially gyms and conference rooms) and transport (planes trains and automobiles each routinely exceed 1000 ppm from everybody’s lungs).

Or dense urban housing. But we're not allowed to criticize that, right. Homes with yards and green space are evil!

You’ll have lower CO2 levels in a dense urban housing with windows open, than in a home in the middle of nowhere with the windows closed.

The issue isn’t the higher amount of CO2 in the ambient air in the cities (AIUI it is; marginally; but it doesn’t matter); it’s that CO2 is very good at concentrating in enclosed spaces.

Re: Vasopressin deficiency: driver of social impairment and fluid imbalance in ASD? [pdf]

#23
post #15

Earlier quoted context omitted.

Or dense urban housing. But we're not allowed to criticize that, right. Homes with yards and green space are evil!

This doesn't follow? The co2 level indoors is decided far more by whether you have the windows open (or perhaps if you're cooking) than whether you have people living close by to you.

Many high rises in urban areas have few windows that open and poor ventilation for cooking. There is a relationship, although maybe not as large as parent is implying.

Re: Vasopressin deficiency: driver of social impairment and fluid imbalance in ASD? [pdf]

#24

Earlier quoted context omitted.

CO2 levels are high in enclosed spaces, not in urban environments

People who live in urban environments statistically spend less time outdoors.

Citation? Won't people who live in small apartments need to go out more often for necessities? I know I did.

Re: Vasopressin deficiency: driver of social impairment and fluid imbalance in ASD? [pdf]

#25
post #8

I’ve theorized in my book _Fat Gas_ that vasopressin levels are tied to elevated indoor CO2 levels. Would not be at all surprised if these novel social conditions stem from not going outside enough and from poorly ventilated buildings (especially gyms and conference rooms) and transport (planes trains and automobiles each routinely exceed 1000 ppm from everybody’s lungs).

Could you elaborate on what you mean by "novel social conditions"?

Re: Vasopressin deficiency: driver of social impairment and fluid imbalance in ASD? [pdf]

#26
post #24

Earlier quoted context omitted.

People who live in urban environments statistically spend less time outdoors.

Citation? Won't people who live in small apartments need to go out more often for necessities? I know I did.

In US cities, going for groceries barely entails time spent outside. You drive your mobile living room to the store and back.

Re: Vasopressin deficiency: driver of social impairment and fluid imbalance in ASD? [pdf]

#27
post #24

Earlier quoted context omitted.

Citation? Won't people who live in small apartments need to go out more often for necessities? I know I did.

In US cities, going for groceries barely entails time spent outside. You drive your mobile living room to the store and back.

The person I replied was speaking specifically about urban areas.

Re: Vasopressin deficiency: driver of social impairment and fluid imbalance in ASD? [pdf]

#28

Earlier quoted context omitted.

CO2 levels are high in enclosed spaces, not in urban environments

People who live in urban environments statistically spend less time outdoors.

Did your source consider time spent in vehicles to be "indoors", "outdoors", or its own category? It definitely makes a difference.

Re: Vasopressin deficiency: driver of social impairment and fluid imbalance in ASD? [pdf]

#29
post #18

You can get tested for this if you have ASD by getting a copeptin test.

What do you change about your lifestyle with that test result? I have a child with ASD, and also drinks mad amounts of water. But I didn't see any treatment plan if this deficiency is confirmed.

Essentially if this theory is accurate it kind of shares similar patterns to diabetes insipidus which is essentially vasopressin dysfunction.

So you can Google that and see how that is treated and tested for.

Re: Vasopressin deficiency: driver of social impairment and fluid imbalance in ASD? [pdf]

#30

That’s a fascinating introduction - they are concerned that dual (!) name of the molecule might be hiding all of its functions! It looks like naming thing is not just a problem for programmers.

When I was diagnosed with a neurological condition that was having mostly physical symptoms, the first-line defense was antidepressants. So-named because they were developed to relieve depression, but really what they do is inhibit absorption of serotonin and/or norepinephrine leaving more free in the body to act on myriad different bodily functions. In my case, it actually caused serious digestion issues. It really clicked for me how everything in your brain is a physical process. Not just motor function, but cognition and emotions are all physical functions of how a very complicated mess of molecules bounce off each other. Autism, Alzheimers, ALS are all just misfiring molecules inside your skull. And it is therefore a given that it is physically possible to realign them back into order somehow. We just need to find the right tool to do it.
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