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Root cause of Alzheimer's may be fat buildup in brain cells, research suggests

medicalxpress.com

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Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests

#91

Post by bratbag »

Dig1t wrote: post #60
Cornbilly wrote: post #58

Earlier quoted context omitted.

There is a weird crowd of people on the internet that have convinced themselves that seed oils are the cause of many ailments. It doesn’t have a ton of scientific backing but Joe Rogan promoted some guru doctor a while back that spread the idea to a lot more people.

>Joe Rogan promoted You mean he did an episode where he had a conversation with the doctor? Or was the doctor a sponsor of the show where he advertised products? I don't think simply having a conversation about an idea counts as promotion. Advertising is another matter though..

I think it stops being just a conversation when you make the choice to broadcast it.

Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests

#92

Post by jcul »

iforgotpassword wrote: post #90
caymanjim wrote: post #72

Earlier quoted context omitted.

The idea that eating fat leads to higher body fat is the most dangerously-wrong health misconception in history.

Honest question: how? I've never seen anyone who's obese and having a diet that made me go "huh that's odd how can they be obese?" While the inverse occasionally has been true, generally people who I consider in good shape appear to eat less, and less greasy food. So while there might be exceptions it seems to be a damn good rule of thumb to me.

Just guessing as to the parent comments meaning.

But I suppose that plenty of fats are healthy and part of a balanced diet. And someone who eats nothing but refined sugar is more likely to be over weight that someone with a high % of fat in their diet.

Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests

#93

Post by bratbag »

rustcleaner wrote: post #73
rustcleaner wrote: post #50

Earlier quoted context omitted.

[flagged]

Biggest comment score hit in a while... (... worth it.)

'At least I annoyed someone' is one of the biggest red flags for a fool who thinks they are smart.

Parties interested in intelligent discourse will avoid you, and lurking readers will cement their opion as opposite yours.

It's the scream of a child rationalising rejection.

Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests

#94

Post by Sparkyte »

ianai wrote: post #40
ProjectArcturis wrote: post #21

As a former Alzheimer's researcher, this is a big fucking deal. It puts together a lot of clues (APOE risk, microglia) and finds a theory that makes a lot of sense. All around the world, there are labs pulling late nights trying to figure out how to drug this.

What kind of fat is it? Like is it possible to avoid by avoiding too much fat?

Probably the combination of sugar and salt. The fats our body makes. Probably doing ketogenics and fasting reduces Alzheimer's.

Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests

#95

Post by aszantu »

VMG wrote: post #84
rustcleaner wrote: post #50

Earlier quoted context omitted.

[flagged]

> The matched subjects who ate meat (including poultry and fish) were more than twice as likely to become demented as their vegetarian counterparts (relative risk 2.18, p = 0.065) and the discrepancy was further widened (relative risk 2.99, p = 0.048) when past meat consumption was taken into account https://pubmed.ncbi.nlm.nih.gov/8327020/

I get migraines from plant and seed oils, my thought on this is, that they're kinda rancid. You can't get them fresh enough in the supermarket. The one oil I didn't get strong migraine from was fresh olive oil.

You're also looking at a time-window of 1-5 days, depending on your metabolism.

Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests

#96

Post by lpapez »

Dig1t wrote: post #65
tux3 wrote: post #62

Earlier quoted context omitted.

Having a conversation in a very public place can certainly end up promoting ideas Take a popular piece of media, inject a conversation about fringe ideas with some crackpot that would have very limited reach otherwise. This gives very high visibility to very fringe ideas. Giving undue weight to fringe viewpoints is promoting those viewpoints.

Promotion: "activity that supports or provides active encouragement for the furtherance of a cause" Simply discussing an idea, even giving undue weight, is not promotion. Conflating the two is dangerous as it provides justification for censorship. The free exchange of ideas and information is the only way a democracy can survive. If the idea is bad or wrong, it will be debated and ultimately defeated in the marketpla…

> If the idea is bad or wrong, it will be debated and ultimately defeated in the marketplace of ideas.

This implies the existence of a marketplace of ideas where people can freely trade thoughts.

It was not the case in the past (i.e. you go to jail or are excommunicated for dissent), and it is increasingly not the case in the modern world (i.e. the algorithm is telling you what they want you to hear).

You cannot have a free marketplace of ideas in a world where the forums these ideas are being discussed have an incentive of causing conflict and keeping you engaged.

This is not an attack on you or anything, I just think we should all be more aware that everything we hear today has an agenda hidden behind it, which is malicious more often than honest.

Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests

#97

Post by WalterBright »

gverri wrote: post #13
atum47 wrote: post #8

My aunt started showing symptoms of Alzheimer's. My grandfather passed from it. Is there any thing to do in order to prevent or delay the disease?

First it would be good to know if you have genetic predisposition. I think mosts comercial DNA tests available test for APOE4 variations. Second I would read on the research of Dr. Dale Bredesen. He has been studying how to map all the underlying factors that can lead to Alzheimer and how to test/treat markers that are associated with the disease. According to him Alzheimer's disease is like a roof full of holes. You…

Even if Dr Bredesen is misdiagnosing the causes of Alzheimer's, his recommendations are still just the basics of healthy living. Like exercise, getting enough sleep, good dental hygiene, etc.

Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests

#98

Post by gfodor »

bratbag wrote: post #93
rustcleaner wrote: post #73

Earlier quoted context omitted.

Biggest comment score hit in a while... (... worth it.)

'At least I annoyed someone' is one of the biggest red flags for a fool who thinks they are smart. Parties interested in intelligent discourse will avoid you, and lurking readers will cement their opion as opposite yours. It's the scream of a child rationalising rejection.

This is true in some forums, but not on this one. On this one, posting things that are even slightly non-consensus leads to grumbling and downvotes.

Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests

#99

Post by mobilejdral »

ProjectArcturis wrote: post #21

As a former Alzheimer's researcher, this is a big fucking deal. It puts together a lot of clues (APOE risk, microglia) and finds a theory that makes a lot of sense. All around the world, there are labs pulling late nights trying to figure out how to drug this.

Can I ask you your thoughts about CYP21A2?

Been studying folks with only one working CYP21A2 due to the resulting atypical adrenal function and I noticed that their dna also contains all the genetic variants associated with Alzheimer's (some are beneficial in this case). Inquiring about the family tree of the single CYP21A2 I have yet to have someone tell me of an ancestor that died of Alzheimer's. But the family members with two good CYP21A2 (and all of the other typical Alzheimer's genetics) are the ones that end up with Alzheimer's. And for good measure, when someone has 3 CYP21A2 nearly always they will get Alzheimer's. (they also end up with Hypercortisolism).

Subclinical Hypercortisolism has a long association with Alzheimer's. A deficient CYP21A2 and the decreased incidences of Alzheimer's is not talked about other than the fact that it isn't associated with Subclinical Hypercortisolism, but Subclinical Hypocortisolism instead.

All of the known indirect early preventative measures for Alzheimer's result in shifting from Subclinical Hypercortisolism towards Subclinical Hypocortisolism.

This was not my intended area of study, but the pattern is interesting and curious for your thoughts.

Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests

#100

Post by Hedepig »

jcul wrote: post #92
iforgotpassword wrote: post #90

Earlier quoted context omitted.

Honest question: how? I've never seen anyone who's obese and having a diet that made me go "huh that's odd how can they be obese?" While the inverse occasionally has been true, generally people who I consider in good shape appear to eat less, and less greasy food. So while there might be exceptions it seems to be a damn good rule of thumb to me.

Just guessing as to the parent comments meaning. But I suppose that plenty of fats are healthy and part of a balanced diet. And someone who eats nothing but refined sugar is more likely to be over weight that someone with a high % of fat in their diet.

I think you're right

The danger is two fold

1. People don't eat fatty foods which have solid evidence for their benefits (e.g. Virgin olive oil)

2. People substitute the lack of fats with sugar, which I believe (not an expert) has a lot literature linking it with obesity

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