31–40 of 205 posts
Paul Saladino has been saying this for over 5 years but people ignore him because he's often shirtless and eats lots of protein.
A broken clock is right two times a day.
Paul Saladino has been saying this for over 5 years but people ignore him because he's often shirtless and eats lots of protein.
Paul Saladino says a lot of things. Which of his claims are you specifically referencing here?
Be careful interpreting this study summary. The article's peer reviews (on PubPeer) list a few analytic issues that call the findings into question: https://pubpeer.com/publications/59F515775D10D854ABB7F4B31D4...
But it could very well be that they're supposed to be the same? Authors may just need to better highlight why the same control is allowed to be use for comparing 2 different result sets.
[0] https://pubpeer.com/publications/59F515775D10D854ABB7F4B31D4...
So, is this why fasting sometimes seems like a solution? Edit: Oversimplified, but: Less, calories, less fat? Excess calories, more fat?
Doesn't this boost the hypothesis that Alzheimer's is closely related to insulin resistance in the brain? What some people call type III diabetes. I ask because one of the hallmarks of insulin resistance is the presence of lipid droplets in close proximity to mitochondria [0]. [0] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10455923/
“Mental disorders are metabolic disorders of the brain”
Doesn't this boost the hypothesis that Alzheimer's is closely related to insulin resistance in the brain? What some people call type III diabetes. I ask because one of the hallmarks of insulin resistance is the presence of lipid droplets in close proximity to mitochondria [0]. [0] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10455923/
If it does boost that hypothesis, what then? Are there things you can do aside from the basic focus on diet, exercise, and sleep?
Highly recommend. I think is what you are looking for.
Paul Saladino has been saying this for over 5 years but people ignore him because he's often shirtless and eats lots of protein.
Earlier quoted context omitted.
There's a really interesting paradox where, compared to healthy adults, intramuscular lipid droplet storage near mitochondria is increased in: 1) People with obesity 2) People with type 2 diabetes 3) People who do endurance exercise Even though #3 is highly protective against #1 and #2. The best explanation I've seen is that the important difference is why the lipid droplets are being deposited [1] [1] https://link.s…
If I am rich enough to have a down payment for a Bay Area house I’ll be tremendously in debt. But that wouldn’t put me in the same boat as someone with oodles of credit card debt. I’m guessing in endurance athletes it’s there because it’s about to be used. In the obese it’s there because they’re running out of places to put fat.
There is also research showing improvement in Alzheimer's disease symptoms. [2]
[1] https://pubmed.ncbi.nlm.nih.gov/11931352/
[2] https://www.sciencedirect.com/science/article/pii/S221287782...
As a former Alzheimer's researcher, this is a big fucking deal. It puts together a lot of clues (APOE risk, microglia) and finds a theory that makes a lot of sense. All around the world, there are labs pulling late nights trying to figure out how to drug this.