As a former Alzheimer's researcher, this is a big fucking deal. It puts together a lot of clues (APOE risk, microglia) and finds a theory that makes a lot of sense. All around the world, there are labs pulling late nights trying to figure out how to drug this.
Root cause of Alzheimer's may be fat buildup in brain cells, research suggests
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Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests
#22Doesn't this boost the hypothesis that Alzheimer's is closely related to insulin resistance in the brain? What some people call type III diabetes. I ask because one of the hallmarks of insulin resistance is the presence of lipid droplets in close proximity to mitochondria [0]. [0] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10455923/
There's a really interesting paradox where, compared to healthy adults, intramuscular lipid droplet storage near mitochondria is increased in:
1) People with obesity
2) People with type 2 diabetes
3) People who do endurance exercise
Even though #3 is highly protective against #1 and #2. The best explanation I've seen is that the important difference is why the lipid droplets are being deposited [1]
[1] https://link.springer.com/article/10.1007/s00424-005-1509-0
Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests
#23Paul Saladino has been saying this for over 5 years but people ignore him because he's often shirtless and eats lots of protein.
A broken clock is right two times a day.
Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests
#24Doesn't this boost the hypothesis that Alzheimer's is closely related to insulin resistance in the brain? What some people call type III diabetes. I ask because one of the hallmarks of insulin resistance is the presence of lipid droplets in close proximity to mitochondria [0]. [0] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10455923/
If it does boost that hypothesis, what then? Are there things you can do aside from the basic focus on diet, exercise, and sleep?
Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests
#25Doesn't this boost the hypothesis that Alzheimer's is closely related to insulin resistance in the brain? What some people call type III diabetes. I ask because one of the hallmarks of insulin resistance is the presence of lipid droplets in close proximity to mitochondria [0]. [0] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10455923/
If it does boost that hypothesis, what then? Are there things you can do aside from the basic focus on diet, exercise, and sleep?
I assume: avoid sugar.
Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests
#26Doesn't this boost the hypothesis that Alzheimer's is closely related to insulin resistance in the brain? What some people call type III diabetes. I ask because one of the hallmarks of insulin resistance is the presence of lipid droplets in close proximity to mitochondria [0]. [0] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10455923/
There's a really interesting paradox where, compared to healthy adults, intramuscular lipid droplet storage near mitochondria is increased in: 1) People with obesity 2) People with type 2 diabetes 3) People who do endurance exercise Even though #3 is highly protective against #1 and #2. The best explanation I've seen is that the important difference is why the lipid droplets are being deposited [1] [1] https://link.s…
If I am rich enough to have a down payment for a Bay Area house I’ll be tremendously in debt. But that wouldn’t put me in the same boat as someone with oodles of credit card debt.
I’m guessing in endurance athletes it’s there because it’s about to be used. In the obese it’s there because they’re running out of places to put fat.
Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests
#27As a former Alzheimer's researcher, this is a big fucking deal. It puts together a lot of clues (APOE risk, microglia) and finds a theory that makes a lot of sense. All around the world, there are labs pulling late nights trying to figure out how to drug this.
Are you aware of any other studies that support this theory? In other words, is this replicable?
Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests
#28Paul Saladino has been saying this for over 5 years but people ignore him because he's often shirtless and eats lots of protein.
Paul Saladino says a lot of things. Which of his claims are you specifically referencing here?
Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests
#29Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests
#30+1 for GLP1
Do GLP1 agents go through the brain blood barrier?
GLP1 analogs can cross the blood–brain barrier and stimulate the GLP1 receptor in the brain.[1]
There is also research showing improvement in Alzheimer's disease symptoms. [2]
[1] https://pubmed.ncbi.nlm.nih.gov/11931352/
[2] https://www.sciencedirect.com/science/article/pii/S221287782...