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Root cause of Alzheimer's may be fat buildup in brain cells, research suggests

medicalxpress.com

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Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests

#11

Post by m463 »

david-gpu wrote: post #4

Doesn't this boost the hypothesis that Alzheimer's is closely related to insulin resistance in the brain? What some people call type III diabetes. I ask because one of the hallmarks of insulin resistance is the presence of lipid droplets in close proximity to mitochondria [0]. [0] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10455923/

sleep problems (like sleep apnea) affect insulin resistance and weight gain. This goes with other evidence that not sleeping correlates with alzheimers. So the fat buildup correlates in a different way.

Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests

#13

Post by gverri »

atum47 wrote: post #8

My aunt started showing symptoms of Alzheimer's. My grandfather passed from it. Is there any thing to do in order to prevent or delay the disease?

First it would be good to know if you have genetic predisposition. I think mosts comercial DNA tests available test for APOE4 variations.

Second I would read on the research of Dr. Dale Bredesen. He has been studying how to map all the underlying factors that can lead to Alzheimer and how to test/treat markers that are associated with the disease.

According to him Alzheimer's disease is like a roof full of holes. You need to test and treat each individual hole to make sure it's not leaking.

Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests

#14

Post by armadsen »

gverri wrote: post #13
atum47 wrote: post #8

My aunt started showing symptoms of Alzheimer's. My grandfather passed from it. Is there any thing to do in order to prevent or delay the disease?

First it would be good to know if you have genetic predisposition. I think mosts comercial DNA tests available test for APOE4 variations. Second I would read on the research of Dr. Dale Bredesen. He has been studying how to map all the underlying factors that can lead to Alzheimer and how to test/treat markers that are associated with the disease. According to him Alzheimer's disease is like a roof full of holes. You…

This is good advice. Be aware that while APOE variants are the most well known and common causes of a genetic predisposition to Alzheimer’s, there are several others, including some 100% penetrance, dominant gene mutations that cause it. Unfortunately I have very significant experience with one of these. Generally it would be common enough in your family (roughly 50% of people getting it), that you’d have reason to suspect one of these gene mutations.

Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests

#15

Post by armadsen »

bananapub wrote: post #3

tl;dr no one knows, lots of hints but every attempt at chemical intervention turns out to be worthless

The latest approved Alzheimer’s drug, Lecanemab, shows a cognitive benefit. It’s modest, but there are already successors in the pipeline that have shown promise (e.g. donanemab). They’re baby steps, not at all cures, and have significant side effects, but “everything we try doesn’t work at all” isn’t really true the way it was even a few years ago.

Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests

#17

Post by mike_d »

delichon wrote: post #10
atum47 wrote: post #8

My aunt started showing symptoms of Alzheimer's. My grandfather passed from it. Is there any thing to do in order to prevent or delay the disease?

[flagged]

As the study points out, we don't even know the mechanism that causes Alzheimer's. Anyone claiming to be able to sway your odds one way or the other is flat out lying because they don't know either.

She is a media personality first and foremost, peddling a book, speaking circuit, private trainings, etc for her fad diet. As for her credentials, remember Dr. Oz was a doctor too before he saw dollar signs.

Here are some good resources for you to check out: https://consumer.ftc.gov/articles/common-health-scams https://www.healthychildren.org/English/family-life/Media/Pa... https://www.nytimes.com/2023/05/10/well/move/fitness-influen...

Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests

#20

Post by ProjectArcturis »

atum47 wrote: post #8

My aunt started showing symptoms of Alzheimer's. My grandfather passed from it. Is there any thing to do in order to prevent or delay the disease?

Leqembi is the only FDA-approved disease-modifying agent. There are a few others that delay the progression of dementia by about 6 months.
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