41–50 of 205 posts
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A broken clock is right two times a day.
A stopped clock is right twice a day. A broken clock could potentially never be right, like if it's perpetually 10 minutes behind.
As a former Alzheimer's researcher, this is a big fucking deal. It puts together a lot of clues (APOE risk, microglia) and finds a theory that makes a lot of sense. All around the world, there are labs pulling late nights trying to figure out how to drug this.
What kind of fat is it? Like is it possible to avoid by avoiding too much fat?
My aunt started showing symptoms of Alzheimer's. My grandfather passed from it. Is there any thing to do in order to prevent or delay the disease?
My dad passed from dementia. That’s the best diagnosis we got. He wouldn’t go in under an MRI machine.
He had horrible , infected teeth. They were badly infected.
There’s linkage of poor oral hygiene and Alzheimer’s.
https://www.health.harvard.edu/mind-and-mood/good-oral-healt...
If I had know this sooner, I would have pushed harder for him to have those bad teeth extracted and had him start using a water pik.
I worry that what he died of was preventable.
GLP1 analogs could help. They can cross the blood–brain barrier and stimulate the GLP1 receptor in the brain.[1] There is also research showing improvement in Alzheimer's disease symptoms. [2] [1] https://pubmed.ncbi.nlm.nih.gov/11931352/ [2] https://www.sciencedirect.com/science/article/pii/S221287782...
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If I am rich enough to have a down payment for a Bay Area house I’ll be tremendously in debt. But that wouldn’t put me in the same boat as someone with oodles of credit card debt. I’m guessing in endurance athletes it’s there because it’s about to be used. In the obese it’s there because they’re running out of places to put fat.
Right - but even then, if a super fit endurance athlete stops exercising, they don't immediately become diabetic. The upstream cause (what biochemical stimulus is driving the fat deposition?) is probably where the key insight lies.
So, is this why fasting sometimes seems like a solution? Edit: Oversimplified, but: Less, calories, less fat? Excess calories, more fat?
Fasting seems like a solution because in the fasted state your body doesn't need to produce insulin. Your body needs insulin to push fat into cells. Your pancreas gets a break, and perhaps sensitivity improves when you go on an extended insulin-free holiday.
No free lunch in personal health decisions, alas. Really the only good advice is stick to well-established science, be healthy in general, avoid internet advice, and don't sweat the small stuff.
As a former Alzheimer's researcher, this is a big fucking deal. It puts together a lot of clues (APOE risk, microglia) and finds a theory that makes a lot of sense. All around the world, there are labs pulling late nights trying to figure out how to drug this.
What kind of fat is it? Like is it possible to avoid by avoiding too much fat?