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High coffee consumption, brain volume and risk of dementia and stroke

tandfonline.com

111–120 of 142 posts

Re: High coffee consumption, brain volume and risk of dementia and stroke

#111

Earlier quoted context omitted.

I doubt I'm the only obnoxious country dude who rolls into Starbucks and orders a "large". You can ignore their pretentious names, they're very accommodating.

Too insecure to use the size names. That's how it plays...fyi

Too much experience with cattle and thus not longing to resemble them. One of 'm says 'moo' and soon the rest follows. Now just imagine a ${city_equivalent_of_field} full of city folk where one of 'm says 'venti' and you understand what I mean.

Re: High coffee consumption, brain volume and risk of dementia and stroke

#112

Is this just related to caffeine, or coffee in general? I drink a LOT of decaf, which probably ends up being 2-4 cups of "real" coffee.

Decaf has less than 10% the caffeine of regular coffee, if I recall correctly. Are you drinking 20 cups of decaf a day?

Re: High coffee consumption, brain volume and risk of dementia and stroke

#113

Earlier quoted context omitted.

A bit of a sidenote, but I find it fascinating how little vitamin deficiencies are accounted for in allopathic medical contexts. Deficiencies seem like such a frequent occurrence but most patients end up needing to self-medicate.

[flagged]

There are billions being made with vitamins

Re: High coffee consumption, brain volume and risk of dementia and stroke

#114

Earlier quoted context omitted.

Twelve hours to metabolize. The six cup people are totally jacked.

Tolerance kicks in. I can drink a double espresso after a dinner and still sleep like an angel.

Perhaps, but do you really know if and how much REM sleep you are getting? I've seen some things that link dementia more specifically to quality of sleep and REM time.

Re: High coffee consumption, brain volume and risk of dementia and stroke

#115

Coffee and tobacco consumption is a known correlation (one of many refs https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158991/ ). Curious to see if authors considered that, as tobacco is one of the main aggressors of vascular tissue, which causes dementia in the long run. EDIT 1: Just in time, UK Biobank (almost 500.000 people) study pointing to increased longevity with coffee consumers, an interesting controversy tha…

Is it to tobacco because of nicotine? Or would things like nicotine gum and lozenges not count. I thought I recalled nicotine potentially being neuroprotective wrt dementia.

Re: High coffee consumption, brain volume and risk of dementia and stroke

#116

Still experimenting with about ~20mg of coffee every other day. Great as part of my pre-workout (as indicated by Huberman's podcast) especially with fats. If I don't add the fats, I definitely feel the edginess and jitteriness... I don't really need it though, wondering if I'm better off just avoiding it? Heard of many other longevity and neural benefits... something I was expecting in this pretty empty study. Self-e…

Well even this study shows reduced risk with moderate consumption compared to the 0 or the 6+ group.

Re: High coffee consumption, brain volume and risk of dementia and stroke

#117
post #2

The article is not claiming causal link, but this is still interesting. >After full covariate adjustment, consumption of >6 cups/day was associated with 53% higher odds of dementia compared to consumption of 1–2 cups/day Coffee is stimulant just like some Alzheimer medications used to treat symptoms. It would be interesting to see if people increase coffee consumption with cognitive decline.

Considering the very early effects of dementia start to impact people sometimes decades before it becomes bad enough that they are diagnosed, it's certainly possible that extreme coffee consumption is some kind of self-medication mechanism. Anecdotally, I've seen this a lot with adults with undiagnosed ADHD (including myself until 26). Caffeine can be a (very shitty) alternative to proper stimulant medication that pe…

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Re: High coffee consumption, brain volume and risk of dementia and stroke

#118

Earlier quoted context omitted.

Considering the very early effects of dementia start to impact people sometimes decades before it becomes bad enough that they are diagnosed, it's certainly possible that extreme coffee consumption is some kind of self-medication mechanism. Anecdotally, I've seen this a lot with adults with undiagnosed ADHD (including myself until 26). Caffeine can be a (very shitty) alternative to proper stimulant medication that pe…

> Anecdotally, I've seen this a lot with adults with undiagnosed ADHD (including myself until 26). Caffeine can be a (very shitty) alternative to proper stimulant medication that people don't realise they actually need because of a medical issue. So the end up drinking 4-5 coffees a day instead. ADHD medication is among the hardest to get in the first place, and to maintain in many places. I was diagnosed as a child,…

To add: At least for methylphenidate, there are several studies showing neuronal long term improvements, "brain normalisation", in people with ADHD. That's rare in psychopharmacology...

I do understand hesitation about immediate release amphetamine, but the retarded formulations are also quite hard to abuse. If you do more than prescribed, you won't get high, you will have a bad time. "Getting high", requires a sudden onset, rush, and sharp peak, which retarded meds won't induce.

Denying people with ADHD to try stims, is really, really unethical considering our knowledge on their effectiveness treating the condition.

Re: High coffee consumption, brain volume and risk of dementia and stroke

#120

Earlier quoted context omitted.

Considering the very early effects of dementia start to impact people sometimes decades before it becomes bad enough that they are diagnosed, it's certainly possible that extreme coffee consumption is some kind of self-medication mechanism. Anecdotally, I've seen this a lot with adults with undiagnosed ADHD (including myself until 26). Caffeine can be a (very shitty) alternative to proper stimulant medication that pe…

Not far fetched at all, seems there's been studies showing a correlation between ADHD and Dementia between genrations. A big question for me is if the ADHD was always even in the older generations there but was non-diagnosed? https://news.ki.se/link-between-adhd-and-dementia-across-gen...

> A big question for me is if the ADHD was always even in the older generations there but was non-diagnosed?

Also could the absence of treatment be causal?

Undiagnosed people suffer immensely trying to cope and adapt to a neurotypical life. Depression and anxiety disorders are commonly found as comorbidities. The above-normal stress default by itself could probably explain all sorts of aging associated disease and symptoms, I presume.

Then you typically find issues with sleep, regular food and water intake ...

And yeah, in context, people with undiagnosed ADHD are much, much more likely to abuse drugs, or "self-medicate". Especially smoking and coffee.

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