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Moderna's mRNA cancer vaccine works better than thought

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Re: Moderna's mRNA cancer vaccine works better than thought

#32
post #29

Earlier quoted context omitted.

> bar for side effects is much stricter for preventative treatments like vaccines These vaccines are for treatment. They don’t prevent cancer. They treat it. They’re vaccines because they work by arming your immune system versus doing the fighting themselves.

> The cancer vaccine: Moderna and pharma giant Merck are developing an mRNA-based cancer vaccine, mRNA-4157 (V940), for people who’ve had high-risk melanomas removed.

> for people who’ve had high-risk melanomas removed

This is still treatment. They aren’t administering the vaccine to healthy adults. The population is melanoma survivors with a high risk of recurrence.

Re: Moderna's mRNA cancer vaccine works better than thought

#33

Earlier quoted context omitted.

What kind of side effects?

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> the ones for the CV vaccine were listed on many pages of tiny text (both from Pfizer and from Moderna)

The size of the pages side effects were written on says absolutely nothing about what the side effects are or their severity.

> Then there are the long term consequences, many studies keep coming out with surprises (recent buzzword “Ribosomal frameshift”

Ribosomal frameshift is in itself not a “long term consequence.” It is simply that depending on where translational of a piece of mRNA starts, different proteins can be produced. This is an essential part of how our own (or any other organism’s mRNA) is translated into proteins. other proteins present in a cell can regulate which proteins can be produced - again an essential part of how our cells function. This has been known about for decades.

It is one of the main potential areas that could lead to side effects of an mRNA vaccine so understanding what other proteins might be translated and under what circumstances is important.

Please don’t fear monger without any actual evidence to back it.

Re: Moderna's mRNA cancer vaccine works better than thought

#34

Earlier quoted context omitted.

What kind of side effects?

[flagged]

Where, exactly, are the long term consequences of mRNA vaccination for SARS-CoV-2? Compared with, say, actually developing COVID? (Please note I’m not arguing that receiving a COVID mRNA vaccine is entirely risk free, however on a risk weighted basis receiving a COVID vaccine is much safer than having COVID)

Re: Moderna's mRNA cancer vaccine works better than thought

#35
post #13

Earlier quoted context omitted.

We have seen how that went during covid, so dont i wouldn't hold your breath on it. The only hope is competition from China and others initiating a race to the bottom.

I mean, it seemed like it worked pretty well with covid. Vaccine was produced very quickly, and in most countries was free.

If by "free" you mean that taxpayers payed huge amounts of money then sure...

Re: Moderna's mRNA cancer vaccine works better than thought

#36
post #28

Earlier quoted context omitted.

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mRNA will eventually save the day for everyone, including for perfectly healthy individuals, but to me as a healthy 40yo person, with no known immunity issues, not overweight etc. etc. it is in my opinion still too risky to take just like that. It's an interesting take. From what we know so far, the risk from taking vaccine is much smaller than from covid infection. You might counter this with highlighting the "so fa…

There's a key difference here that cancer mRNA vaccine you are taking after you've been diagnosed with cancer.

Otherwise for Coronavirus vaccines you couldn't argue that risks are much smaller for any given person under any given conditions. E.g. a person could be completely isolated for the next 10 years and have virtually 0% chance of getting Covid-19, so in this case there's no calculation that could show a vaccine being with more favourable benefits/risks.

If there's a 1/10,000 chance of giving you a sore shoulder that would be worse in the calculations if you are for sure to be isolated from being anywhere near the virus.

Re: Moderna's mRNA cancer vaccine works better than thought

#37
Should this really be called a “vaccine”? I feel like that is going to give people the wrong impression about what it does. I think labelling it gene therapy, immune therapy, or something like that would be closer to what it actually does.

Also really interested to see if people will need and/or benefit from periodic re-treatment. I guess they can figure that part out if it makes it to market.

Re: Moderna's mRNA cancer vaccine works better than thought

#38
post #13

Earlier quoted context omitted.

We have seen how that went during covid, so dont i wouldn't hold your breath on it. The only hope is competition from China and others initiating a race to the bottom.

I mean, it seemed like it worked pretty well with covid. Vaccine was produced very quickly, and in most countries was free.

It wasn't free, just paid by the government means tax money means money that's now missing for other things in countries like Germany because they still are fixated on the 60% debt ceiling based on an Excel error.

Re: Moderna's mRNA cancer vaccine works better than thought

#39

Should this really be called a “vaccine”? I feel like that is going to give people the wrong impression about what it does. I think labelling it gene therapy, immune therapy, or something like that would be closer to what it actually does. Also really interested to see if people will need and/or benefit from periodic re-treatment. I guess they can figure that part out if it makes it to market.

Yes the word 'vaccine' seems misleading to me as well, as people tend to think of vaccinations as ways to prevent contagious illness. I think immune therapy is a much better term.

Re: Moderna's mRNA cancer vaccine works better than thought

#40

Earlier quoted context omitted.

[flagged]

For coronavirus maybe, because it's not much of danger for you in the first place, but those risks would be thousands of times more acceptable for cancer. There are no side effects observed from mRNA CV vaccines that could be worse when compared to cancers with 1%+ mortality rate. As a reminder you won't be taking it before the cancer, you would be taking it after the fact.

There are maybe no effects that we know about right now. Different people have different opinions on what their risk tolerance is, so there could be people that may outright disagree with your statement.

And there were even fewer such effects when the vaccines have rolled out back in 2020 with emergency approval, but without being used “in production” beforehand.

Now we know much more about the mRNA platform, but I still can’t exclude the possibility entirely for me. So I will take my chances and focus much more on quality of food, on staying fit, reducing stress etc. etc.

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