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One sleepless night can rapidly reverse depression for several days in mice

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Re: One sleepless night can rapidly reverse depression for several days in mice

#91
post #84

Earlier quoted context omitted.

My anxiety now is that using THC to sleep will cause issues long term. But without it I literally cannot get to sleep anymore. Edit: I regret pulling focus off parent comment and OP, but also deeply appreciate everyone’s comments.

Tapering off very slowly (over weeks or months) will probably work better than cold turkey.

I’m just now sure how to taper off. They don’t come in smaller doses than 5mg and that’s where I’m at.

Re: One sleepless night can rapidly reverse depression for several days in mice

#92
post #50

Earlier quoted context omitted.

Are you claiming that 2-3h of sleep is enough or healthy?

Why don't you try it and see? Some of my best sleeps were after a sleepless night and for only like 1-3 hours, caffeine or other stimulants in the blood be damned Edit: also make sure you have bright blue light during wakeup/morning/day and mellow non-overhead orangey/amber/yellow light (nothing east of yellow) at evening/night. Red 2 hours before bedtime for bonus "points"

My experience does not match up with yours here.

Given work deadlines I have a lot of experience with full all-nighters and 1-3 hour nights.

Re: One sleepless night can rapidly reverse depression for several days in mice

#93

Having suffered from severe depression for over forty years, this reminds me of when I was 17, 18, etc. and suddenly discovered that if I stayed up for two days, the problem went away. So I knew this a very long time ago; but it always seemed to me that, besides smoking, this was just about one of the worst habits you could develop. By my mid-twenties, I had stopped.

I recently was forced off of SSRIs after nearly ten years because I lost my psychiatrist and couldn't get a new one because the waitlists were ridiculous.

After 10 years on them, the next 6 months were absolute hell (i legit thought at one point I might go full Joaquin Phoenix in Joker) but I made it through, no small part thanks to my wonderful amazing wife.

Rebound depression have been an issue - though in general I feel like I am much better off without the antidepressants now than with them - and I've also noticed that pulling an all nighter would actually fix the rebounds for a bit. A small dose of melatonin before bed worked wonders for me now. I sleep better and the rebounds are extremely rare.

Re: One sleepless night can rapidly reverse depression for several days in mice

#94
post #42

Earlier quoted context omitted.

Is your normal state depressed though? I don’t think it works for “normal” people.

The study was done on mice. Are there depressed mouse that are used in such experiments or is this just an opinion on why zdragnar might not feel these effects? This is a genuine question.

It is possible to artificially induce depression in mice, yes. Obviously, the whole field is insanely fraught with ethical dilemmas.

Re: One sleepless night can rapidly reverse depression for several days in mice

#95

The article "One Sleepless Night Can Rapidly Reverse Depression for Several Days" is a fascinating and promising piece of research. The findings suggest that sleep loss could be a potential treatment for depression, which is a debilitating condition that affects millions of people worldwide. I am particularly interested in the implications of this research for many people. I believe that this research could lead to n…

Was this written by an LLM?

If you mean the comment, I think so. That's why it is probably flagged

Re: One sleepless night can rapidly reverse depression for several days in mice

#96

Earlier quoted context omitted.

My anxiety now is that using THC to sleep will cause issues long term. But without it I literally cannot get to sleep anymore. Edit: I regret pulling focus off parent comment and OP, but also deeply appreciate everyone’s comments.

My brother basically needs THC to sleep. Or strenuous physical activity all day.

> Or strenuous physical activity all day.

The lack of strenuous physical activity all day is a real problem with modern life. We did not evolve to be sedentary.

Re: One sleepless night can rapidly reverse depression for several days in mice

#97
If you've never tried a Ragnar race, you should consider it. It's a 36 hour-ish team relay race, with non runners driving in a van to meet runners at the next relay spot. You barely sleep, but the 1-2 hours you get are probably the deepest you'll ever feel. The next day you are exhausted and yet feel amazing at the same time.

Re: One sleepless night can rapidly reverse depression for several days in mice

#98

Having suffered from severe depression for over forty years, this reminds me of when I was 17, 18, etc. and suddenly discovered that if I stayed up for two days, the problem went away. So I knew this a very long time ago; but it always seemed to me that, besides smoking, this was just about one of the worst habits you could develop. By my mid-twenties, I had stopped.

My anxiety now is that using THC to sleep will cause issues long term. But without it I literally cannot get to sleep anymore. Edit: I regret pulling focus off parent comment and OP, but also deeply appreciate everyone’s comments.

You'll get plenty of advice and it's worth evaluating it all (as we're all different), but trazodone has been a miracle worker in aiding sleep. It's cheap, well understood, and the only negative aspect I've encountered is the risk of priapism (which can sound like a joke but should be taken very seriously)

Re: One sleepless night can rapidly reverse depression for several days in mice

#99
post #77

> Chronic sleep loss is well studied, and it’s uniformly detrimental effects are widely documented,” Kozorovitskiy said. I believe he didn't say "it's", he probably said "its".

sort of interesting how your/you're, its/it's, shrimps/softwares and others sort of unconsciously makes what you're reading less authoritative in a 4th wall way.

Not even unconsciously, I stop reading anything I've been reading once I meet one of these. It's disrespectful to the reader to not even check what's the correct spelling of a word you are using, and in my opinion indicates that the writer is not intelligent enough to recognize patterns in text, it really isn't that hard to see how a word is used in the wild. Kind of a hot take

Re: One sleepless night can rapidly reverse depression for several days in mice

#100
post #69

Earlier quoted context omitted.

Being unable to sleep is a common withdrawal symptom for cannabis use disorder. Congratulations, you are habituated, and long-term problems are likely accumulating as you are losing out on REM sleep and probably developing emotional and physical conditions related to cannabis use. Good luck!

damn, so I'm screwed and I don't even get to enjoy the upsides of cannabis. Rough world.

I’ve smoked weed before bed most nights for at least a decade, and if I happen to skip a night I… still sleep fine, unless I’ve had no exercise that day.
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