Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

One sleepless night can rapidly reverse depression for several days in mice

news.northwestern.edu

Post reply on HN
Print view View original

51–60 of 312 posts

Re: One sleepless night can rapidly reverse depression for several days in mice

#51

Post by Kbelicius »

baxtr wrote: post #42
zdragnar wrote: post #39

Weird, whenever I pull an all nighter my mood is usually noticeably depressed for the following two days. I also used to be a bit of an insomniac, and one sleepless night could easily throw off my circadian rhythm, creating all sorts of extra anxiety, which translates into demand avoidance, stress and furthering depression.

Is your normal state depressed though? I don’t think it works for “normal” people.

The study was done on mice. Are there depressed mouse that are used in such experiments or is this just an opinion on why zdragnar might not feel these effects? This is a genuine question.

Re: One sleepless night can rapidly reverse depression for several days in mice

#52

Post by jvm___ »

https://www.reddit.com/r/hangovereffect/

This sub-reddit is dedicated to people who've noticed this effect for ADHD and probably depression as well. Drinking alcohol somehow causes the same 'reversal' of symptoms, either motivation or other mood problems. Lots of discussion as to what causes it - and questions/theories on how to reproduce without alcohol.

Alcohol causing sleeplessness, or sleep that's not the usual quality might be an explanation.

Re: One sleepless night can rapidly reverse depression for several days in mice

#53

Post by lucia-goldsmith »

The article "One Sleepless Night Can Rapidly Reverse Depression for Several Days" is a fascinating and promising piece of research. The findings suggest that sleep loss could be a potential treatment for depression, which is a debilitating condition that affects millions of people worldwide.

I am particularly interested in the implications of this research for many people. I believe that this research could lead to new and innovative treatments for depression, which would be a major breakthrough in the field of mental health.

However, I am also aware of the potential risks associated with sleep loss. Sleep is essential for physical and mental health, and sleep deprivation can have a number of negative consequences, including cognitive impairment, increased risk of accidents, and worsening of existing mental health conditions.

Therefore, I believe that it is important to carefully consider the potential benefits and risks of sleep loss before using it as a treatment for depression. More research is needed to determine whether sleep loss can be safely and effectively used in a clinical setting.

I am optimistic that this research will lead to new and effective treatments for depression. I am also hopeful that this research will raise awareness of the importance of sleep for both physical and mental health.

Re: One sleepless night can rapidly reverse depression for several days in mice

#54

Post by Obscurity4340 »

dgb23 wrote: post #50
Obscurity4340 wrote: post #34

Earlier quoted context omitted.

The sleep quality is super lossless and actually gainful when you compress it by allowing a slight sleep debt to accrue

Are you claiming that 2-3h of sleep is enough or healthy?

Why don't you try it and see? Some of my best sleeps were after a sleepless night and for only like 1-3 hours, caffeine or other stimulants in the blood be damned

Edit: also make sure you have bright blue light during wakeup/morning/day and mellow non-overhead orangey/amber/yellow light (nothing east of yellow) at evening/night. Red 2 hours before bedtime for bonus "points"

Re: One sleepless night can rapidly reverse depression for several days in mice

#57

Post by datameta »

Waterluvian wrote: post #45
Hard_Space wrote: post #35

Having suffered from severe depression for over forty years, this reminds me of when I was 17, 18, etc. and suddenly discovered that if I stayed up for two days, the problem went away. So I knew this a very long time ago; but it always seemed to me that, besides smoking, this was just about one of the worst habits you could develop. By my mid-twenties, I had stopped.

My anxiety now is that using THC to sleep will cause issues long term. But without it I literally cannot get to sleep anymore. Edit: I regret pulling focus off parent comment and OP, but also deeply appreciate everyone’s comments.

Try Type III cannabis (high cbd hemp). Nowadays it looks and smells like Type I cannabis (the high thc standard variety of weed). It has all the various combinations of cannabinoids, terpenes, and flavonoids that contribute to the entourage effect except for THC (i.e. amongst non-psychoactive hemp flower there are relaxing indicas for insomnia, functional hybrids for chronic pain, sativas for a pick-me-up, etc.

Re: One sleepless night can rapidly reverse depression for several days in mice

#58

Post by dotnet00 »

wouldbecouldbe wrote: post #27
shikshake wrote: post #4

This must be why new parents always seem so bubbly and happy! But seriously, that’s very interesting and explains what I’ve experienced. I’ve been in a depression since quitting my phd a couple months ago and not having a direction in life, but whenever I have trouble sleeping I end up feeling better the next day. Maybe I’ll trying utilizing it to get my portfolio looking better.

I don’t know. Seems very correlated with people having a good reason to pull an all nighter. Whether kids or business. Meaning makes us tick

Yeah I feel like this is probably a big part of it. Nothing does away with my depressive existential dread better than just having any kind of work to do, be it working on a personal skill or employment related work.

Re: One sleepless night can rapidly reverse depression for several days in mice

#59

Post by culi »

wouldbecouldbe wrote: post #27
shikshake wrote: post #4

This must be why new parents always seem so bubbly and happy! But seriously, that’s very interesting and explains what I’ve experienced. I’ve been in a depression since quitting my phd a couple months ago and not having a direction in life, but whenever I have trouble sleeping I end up feeling better the next day. Maybe I’ll trying utilizing it to get my portfolio looking better.

I don’t know. Seems very correlated with people having a good reason to pull an all nighter. Whether kids or business. Meaning makes us tick

It's an experimental study not an observational study. So that correlation won't have an effect here

Re: One sleepless night can rapidly reverse depression for several days in mice

#60

Post by Loughla »

Waterluvian wrote: post #45
Hard_Space wrote: post #35

Having suffered from severe depression for over forty years, this reminds me of when I was 17, 18, etc. and suddenly discovered that if I stayed up for two days, the problem went away. So I knew this a very long time ago; but it always seemed to me that, besides smoking, this was just about one of the worst habits you could develop. By my mid-twenties, I had stopped.

My anxiety now is that using THC to sleep will cause issues long term. But without it I literally cannot get to sleep anymore. Edit: I regret pulling focus off parent comment and OP, but also deeply appreciate everyone’s comments.

So I feel like you exactly identified the long term problem in the same paragraph.

I learned years ago that any chemical that helps you sleep ensures that you can't sleep without it. I've used everything from thc to Benadryl to lavender and everything in between.

It all had the same effects: slowly degrading effectiveness and sleeplessness without it.

Pro-tip: find the source of your insomnia. Is it chemical or is it electrical or is it just habit? Doing a real sleep test and working with doctors was life changing. Mine was habit and anxiety. Meditation and therapy have helped.

Anecdotal, I know. But what happens when the thc runs out? You crash. That's what I did.

Post reply on HN