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The Uselessness of Phenylephrine (2022)

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Re: The Uselessness of Phenylephrine (2022)

#111
post #58

My kids seem to derive benefit from chewable tablets which I tell them to suck on. Curious if anyone has found different research on metabolization in the mouth versus gut?

Oral and rectal blood goes directly to the greater circulation without going through the liver (that metabolizes most toxins) first.

Re: The Uselessness of Phenylephrine (2022)

#112
post #86
post #80

Earlier quoted context omitted.

I wonder if it will work as a suppository.

It’s worth a try. I’d recommend buying a separate spray for your nose though.

Reminds me of the old joke: what's the difference between an oral thermometer and a rectal thermometer?

Answer: the taste

Re: The Uselessness of Phenylephrine (2022)

#113
post #27

Earlier quoted context omitted.

Indeed. I've known that phenylepherine is worthless for a long while, and just make it a point to buy a pack of the real stuff every 6 months or so, so that I always have it on hand when I need it. In my state, it's controlled - you have to get it from a pharmacist (though you can do so without a prescription) - they take your driver's license and don't allow you to purchase it too often.

You can buy 6 boxes of sudafed per month (24 doses each). Isn’t that more than the recommended (and probably safe) daily limit? I dont doubt your intentions but I don’t think you actually need 6 boxes per month + a stash.

They mention one box every six months, which is entirely reasonable.

Re: The Uselessness of Phenylephrine (2022)

#114
post #98

Earlier quoted context omitted.

What they're going to do with it is prevent me from making a purchase if I've crossed some arbitrary limit as if exceeding that limit automatically makes me a drug trafficker. From there, it's not too far of a stretch to imagine the government assigning someone to review the list and to expend additional investigative resources into merely "suspicious" cases. Plenty of good tragedies start this way. If the government…

They're just going to say "no", right? They're not going to "automatically make you a drug trafficker". They're just trying to enforce a rate limit.

So, if the concern isn't that I'm trafficking, then why am I being told no? Isn't this the logic the government used to assert this right for itself in the first place?

Otherwise, what right is it of the government to enact this rate limit? What interest are they protecting? How is the rate limit decided? What can I do if I disagree with the rate limit? Why is a private business being burdened with the governments agenda here?

I get where you're coming from, it _is_ a /small/ thing, but the implications immediately become onerous if you think about their meaning inside of a "free" country.

Re: The Uselessness of Phenylephrine (2022)

#115

Public service announcement: sinus rinse (e.g. NeilMed) works. Available in every drug store with no prescription or pharmacist involvement necessary. It's gross, though. Do it in private.

I have swollen nasal polyps (or something) which causes every single cold I get to eventually transform into a 2 week sinus infection + cough ordeal.

Netty pot with salty water and a pinch of baking soda, and an even saltier water gargle clears things up nicely. And is very budget friendly.

Re: The Uselessness of Phenylephrine (2022)

#116
Phenylephrine is ineffective when taken orally. It is super effective topically or iv. I can definitely tell, because it's the most commonly used vasopressor used under anaesthesia (iv). Also used topically to avoid nosebleeds during nasal intubation.

Re: The Uselessness of Phenylephrine (2022)

#117
post #33

I laughed out loud when I read about the lobbyists who are trying to keep phenylephrine from being taken off store shelves. In one article about the FDA panel vote, a lobbyist said that most consumers hate the alternatives -- nasal sprays because of the discomfort and pseudoephedrine because it's stored behind the pharmacy counter -- and so depriving them of a hassle-free option is anti-consumer. The fact that the ha…

My understanding is the nasal spray version works, but the oral just gets metabolized ineffectively?

Thank you for sharing, if this is true it will win me a really good arguement. I know someone who hates Phenylephrine, so I will buy some nasal spray just to surprise them.

Re: The Uselessness of Phenylephrine (2022)

#118

The fact that phenylepherine is ineffective is quite old and has been common knowledge for many years. What is news is that the FDA is finally acknowledging it. I've maintained my own reserve of pseudoephedrine for years. https://gizmodo.com/report-many-over-the-counter-decongestan... https://www.forbes.com/sites/daviddisalvo/2015/10/26/the-pop... https://www.newscientist.com/article/2089555-breaking-bad-sn...

I just came here to say that I actually find phenylephrine nasal spray quite effective - but I use it for a different use case: stopping nosebleeds quickly. It's quite effective at that and came recommended by an ENT, so I do believe it's an effective vasoconstrictor when applied locally and I'm glad it's available.

You are correct.

Re: The Uselessness of Phenylephrine (2022)

#119
post #27

Earlier quoted context omitted.

Indeed. I've known that phenylepherine is worthless for a long while, and just make it a point to buy a pack of the real stuff every 6 months or so, so that I always have it on hand when I need it. In my state, it's controlled - you have to get it from a pharmacist (though you can do so without a prescription) - they take your driver's license and don't allow you to purchase it too often.

You can buy 6 boxes of sudafed per month (24 doses each). Isn’t that more than the recommended (and probably safe) daily limit? I dont doubt your intentions but I don’t think you actually need 6 boxes per month + a stash.

The point is more to not be in a position to have to go out and buy some when I'm feeling cruddy. Since it's controlled, I can't just have some shipped to my door when I'm laying in bed sick. I just got in the habit of picking it up periodically to ensure that it's on hand when I need it.

Re: The Uselessness of Phenylephrine (2022)

#120
post #96

Earlier quoted context omitted.

Anything a government uses to uniquely identify and track individuals (i.e. driver's license) is the target.

Until very recently, drivers license numbers were effectively public in a lot of states (they're deterministically generated from public information).

Hey, that's pretty cool. I suppose I now know Ron DeSantis's drivers license number up to the last digit. And the soundex algorithm is cool (using fuzzy lookup in a list that way to get close/vague matches is novel to me and might be useful). I had heard of soundex but didn't know how it worked until now. Thanks for the TILs!

https://stevemorse.org/dl/dl.html

http://www.highprogrammer.com/alan/numbers/index.html

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