Earlier quoted context omitted.
> "what if the obesity epidemic has nothing to do with calories in vs calories out, and actually there is some toxin which the body has to sequester in subcutaneous fat and that's why everyone's getting obese" Everyone loses weight on a caloric deficit. And "doubly labeled water" experiments show that people vastly underestimate how many calories they actually eat each day. See this often cited paper: https://www.nej…
Just to be clear, I am trained as a physicist and I am not criticizing the thermodynamics as incorrect but rather insufficient . It is also incorrect, which is to say that there is only a vague relationship between the kilocalories reported on the side of the box and the actual marginal energy absorbed into your body. This is due to multiple factors. The most basic is measurement methodology: “count up the carbs in g…
CICO doesn't have any opinion on the relative satiation offered by sugars vs proteins, or bread vs potatoes, but it turns one's diet into a marketplace for satiation, which does teach which foods are the best "value" per kcal (even if a kcal is itself very inaccurate).
Maybe we'll see it as a dated but situationally valid tool, like leeches or "Red sky at night, shepard's delight".