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Scientists may have found mechanism behind cognitive decline in aging

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Re: Scientists may have found mechanism behind cognitive decline in aging

#181

Post by CodeSgt »

phkahler wrote: post #156
swalsh wrote: post #16

I've noticed a cognitive decline in myself the past couple years. I'm in my mid 30's though so I assume it's more related to long covid. One of the biggest side effects of long covid for me was horrible insomnia, which was killer. The insomnia is mostly gone, but I'm still not my previous cognitive self. It's terrifying to be honest.

I've found that going to the gym and lifting weights will clear my head. That wasn't necessary pre-covid though.

Agreed! Similarly, ice baths/cold plunges are a great way for me to mentally “reset” and clear up a little brain fog. Minimizing carbs has, for me, also helped. Not eliminating them mind you, but reeling my consumption of them in to a healthy level and focusing on proteins, fruits, veggies, etc for most of my caloric intake.

Re: Scientists may have found mechanism behind cognitive decline in aging

#182

Post by DANmode »

koheripbal wrote: post #175
smallerdemon wrote: post #155

Fingers crossed that it can actually be replicated in future studies and research. We definitely don't want another nearly 20 years of false path ass busting research based on falsified documentation like we ended up with on Alzheimer studies.

I thought the fraud did not invalidate the results and that plaque was still considered the primary cause. In fact, wasn't there a drug recently released that demonstrated that?

Did it demonstrate plaque as cause, or effect (that gets cleaned up with meds)?

Re: Scientists may have found mechanism behind cognitive decline in aging

#183

Post by roflc0ptic »

koheripbal wrote: post #175
smallerdemon wrote: post #155

Fingers crossed that it can actually be replicated in future studies and research. We definitely don't want another nearly 20 years of false path ass busting research based on falsified documentation like we ended up with on Alzheimer studies.

I thought the fraud did not invalidate the results and that plaque was still considered the primary cause. In fact, wasn't there a drug recently released that demonstrated that?

No. There was a drug released that targeted that pathway, but the approval in and of itself was a scandal - I spoke with a pharmacist last night who said people at her hospital were disgusted by the FDA’s decision. It was removed from the market two weeks later. There was basically no evidence of efficacy.

Re: Scientists may have found mechanism behind cognitive decline in aging

#184

Post by CodeSgt »

pja wrote: post #18
swalsh wrote: post #16

I've noticed a cognitive decline in myself the past couple years. I'm in my mid 30's though so I assume it's more related to long covid. One of the biggest side effects of long covid for me was horrible insomnia, which was killer. The insomnia is mostly gone, but I'm still not my previous cognitive self. It's terrifying to be honest.

Quality of sleep makes a huge difference to your mental faculties. If you could bottle it, the effect would be a multi, multi $billion drug.

I’m prescribed trazadone for insomnia, and it’s magnificent. Virtually zero grogginess the next morning like I’d get from an anti-histamine, no compromise on sleep quality as the drug actually improves length and quality of REM sleep rather than negatively impacting it as many other sleep-aids do.

Re: Scientists may have found mechanism behind cognitive decline in aging

#185

Post by DANmode »

jpcfl wrote: post #135
agloe_dreams wrote: post #120

Earlier quoted context omitted.

Also, get checked up for Sleep Apnea. It is a truly life-ruining condition whose primary side effect is lost memory and cognitive function.

Holy shit this. I went years undiagnosed. Saw a dozen doctors. Couldn’t get an clear explanation for why I was always tired, brain fog, vision problems, joint pain, memory issues. The list goes on. Then my _dentist_ of all people ordered a Watch-PAT take-home sleep test (took a lab sleep test, but it was useless) which finally revealed I was having more than 10 events per hour. The dentist made me a Herbst appliance…

What region is this?

Excellent catch.

Re: Scientists may have found mechanism behind cognitive decline in aging

#186

Post by CyberDildonics »

mdp2021 wrote: post #109
Roark66 wrote: post #77

In mice! Seriously, is it so difficult to add those two words in the title?

That would change the title into your reading. The title is literal. Pharmacological treatments are proposed - for humans.

That would change the title into your reading.

What does that mean?

The title is literal.

It is literally incomplete and the missing context changes the entire meaning.

Pharmacological treatments are proposed - for humans.

This isn't what the title says or implies.

Re: Scientists may have found mechanism behind cognitive decline in aging

#187

Post by acters »

MagicMoonlight wrote: post #160

Eventually we will reach a point where humans are immortal. They’ll still die if they’re shot or clog their arteries etc but they won’t die purely based on running down a clock. There’s no inherent reason we have to die. It’s an evolved strategy to allow newer models to replace us. Turn that off and you’d stay around until physical damage and irreparable decay takes you out. It will be interesting from a societal sta…

Who is to say we are not reaching the levels of irreparable decay or physical damage to render death more likely? Instead of death, how about the years or months before the eventuality where we are losing our capabilities in a variety of methods? I say we are reaching this type of milestone you have spoken about in your comment. Even the tidbit about rich people hogging resources because they are doing exactly that right now!

I say this because I do believe that a lot of research into aging is just finding a lot of strange oddities in our genes, and biological mechanisms. There was never any long term biological process such as natural selection, darwinism and survivorship bias to remove or refine them into something that works better or works for indefinite lengths of time. It is only recently that more humans are able to live 60+ years and that there is billions of humans compared to the numbers of live humans in previous centuries.

Re: Scientists may have found mechanism behind cognitive decline in aging

#188

Post by pmorici »

swalsh wrote: post #16

I've noticed a cognitive decline in myself the past couple years. I'm in my mid 30's though so I assume it's more related to long covid. One of the biggest side effects of long covid for me was horrible insomnia, which was killer. The insomnia is mostly gone, but I'm still not my previous cognitive self. It's terrifying to be honest.

I doubt it is much to do with COVID. Mid 30’s is about the time when you have to start paying closer attention to things like sleep and exercise or everything starts to go to shit.

Re: Scientists may have found mechanism behind cognitive decline in aging

#189

Post by dd36 »

koheripbal wrote: post #180
herval wrote: post #136

Earlier quoted context omitted.

I had the same after COVID. Took me many months to start feeling functional again. Any time I tried to think about something, it'd just... noise out? First 2-3 months were just awful I went to a neurologist who said there's tons of people coming in with the same complaint after COVID, and since there's no literature on that yet, he couldn't really do anything. It gets better.

I wonder how many people just fell into alcohol, isolation induced depression, sedentary lifestyle, weight gain, etc... and that their health decline had nothing to do with COVID. That's the issue with these anecdotes

OP did not claim their comment wasn’t an anecdote…

Re: Scientists may have found mechanism behind cognitive decline in aging

#190

Post by hgsgm »

matwood wrote: post #85
swalsh wrote: post #16

I've noticed a cognitive decline in myself the past couple years. I'm in my mid 30's though so I assume it's more related to long covid. One of the biggest side effects of long covid for me was horrible insomnia, which was killer. The insomnia is mostly gone, but I'm still not my previous cognitive self. It's terrifying to be honest.

> I've noticed a cognitive decline in myself the past couple years. How have you measured? I know people do decline cognitively in old age, but 30s is still young. I wonder if people only think they were sharper when younger. I knew much less in my 20s and made tons of mistakes. The mind has a peculiar way of highlighting good memories and downplaying the bad. The person I was in my 20s would not be able to do my cur…

It is an extraordinary claim to say that people think as fast in their 30s as 30s. Billions of people have direct experience over thousands of years.

Yes, accumulated knowledge and wisdom can make you more successful with age. It doesn't mean your fluid intelligence and ability to learn new things is keeping up.

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