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Scientists may have found mechanism behind cognitive decline in aging

news.cuanschutz.edu

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Re: Scientists may have found mechanism behind cognitive decline in aging

#171

Post by ilteris »

amelius wrote: post #28
rapsey wrote: post #24

Earlier quoted context omitted.

Are you taking vitamin d? If not you absolutely should. Magnesium at the same time as D3 and then glycine and another dose of magnesium before bed. This is the magic formula for me.

If you take a lot of vitamin d, make sure you also take vitamin k. Just a random source here because I'm too lazy: https://www.balancedwellbeinghealthcare.com/are-you-taking-v... > Because vitamin D is so good at improving calcium levels, by taking it alone you could be working to increase the calcification of your arteries instead of strengthening your bones so make sure to include K2 in your vitamin D supplement re…

Do you have any recommendations for K2? A generic brand would be okay? Thanks

Re: Scientists may have found mechanism behind cognitive decline in aging

#172

Post by Mistletoe »

>Normal aging reduces the amount of nitric oxide in the body. That in turn reduces nitrosylation which decreases memory and learning ability, the study said.

Has viagra shown affects at reducing normal aging in the brain? It seems to do so in the heart.

https://news.vcu.edu/article/Nitric_Oxide_release_triggered_...

Re: Scientists may have found mechanism behind cognitive decline in aging

#173

Post by isaacfrond »

freehorse wrote: post #25

> Researchers using mouse models found that altering the CaMKII brain protein caused similar cognitive effects as those that happen through normal aging. This should be the title of the article. Honestly these supposedly dissemination articles do not offer much more than reading the abstract or skimming a bit through the article itself. https://www.science.org/doi/10.1126/scisignal.ade5892

doesn’t quite fit in HN’s 80 character limit though

Re: Scientists may have found mechanism behind cognitive decline in aging

#174

Post by throw__away7391 »

kyriakos wrote: post #168
MagicMoonlight wrote: post #160

Eventually we will reach a point where humans are immortal. They’ll still die if they’re shot or clog their arteries etc but they won’t die purely based on running down a clock. There’s no inherent reason we have to die. It’s an evolved strategy to allow newer models to replace us. Turn that off and you’d stay around until physical damage and irreparable decay takes you out. It will be interesting from a societal sta…

Immortality raises a lot of ethical and philosophical questions that we will need to tackle if it ever becomes real. For example, if you live 200 years, how much would you remember of your first 30 years of life? Will that 200 year old person still technically be the same as the one that was born if he hardly remembers anything?

No it doesn't.

I'm a good bit younger than 200 and barely remember large portions of my earlier life already. What's so special about 200 that makes it any different?

Re: Scientists may have found mechanism behind cognitive decline in aging

#175

Post by koheripbal »

smallerdemon wrote: post #155

Fingers crossed that it can actually be replicated in future studies and research. We definitely don't want another nearly 20 years of false path ass busting research based on falsified documentation like we ended up with on Alzheimer studies.

I thought the fraud did not invalidate the results and that plaque was still considered the primary cause.

In fact, wasn't there a drug recently released that demonstrated that?

Re: Scientists may have found mechanism behind cognitive decline in aging

#176

Post by slv77 »

mdp2021 wrote: post #114
loopdoend wrote: post #87

Earlier quoted context omitted.

Look up Bhramari Pranayama. Humming directly increases nitric oxide levels.

Do you have a reference? (About the relation.)

Humming increasing nitric oxide production is well documented. Here is one journal article but there are others:

https://erj.ersjournals.com/content/22/2/323

Nitric Oxide dilates the nasal passages and is also a vasodilator as well. A simple n=1 test is to do nasal humming and test blood pressure before and after. I can typically get a (temporary) 10 point drop.

Nitric Oxide is also anti-bacterial and humming may help clear sinus infections.

Re: Scientists may have found mechanism behind cognitive decline in aging

#177

Post by koheripbal »

freehorse wrote: post #25

> Researchers using mouse models found that altering the CaMKII brain protein caused similar cognitive effects as those that happen through normal aging. This should be the title of the article. Honestly these supposedly dissemination articles do not offer much more than reading the abstract or skimming a bit through the article itself. https://www.science.org/doi/10.1126/scisignal.ade5892

Because the authors only read the abstracts.

Re: Scientists may have found mechanism behind cognitive decline in aging

#178

Post by koheripbal »

simonjgreen wrote: post #159
xkbarkar wrote: post #153

Earlier quoted context omitted.

How did this go to the top vote? Brings nothing about the article just dubious personal long covid claims. HN please stop upvoting this nonsense. Already the second and third answers are HN quality. This is r/covid commentary. Does not belong here.

And yet the volume of replies, advice, and questions, against this suggests it's brought enjoyable conversation. On-topic is shades of grey.

Popularity is not a proxy for quality.

...and just like Reddit, chasing popular posts and comments is a race to the bottom as it attracts an ever-more juvenile crowd of participants.

Nuanced opinions and expert commentary are more boring but attract a more intellectually curious crowd - and that is what sets HN apart from reddit.

Re: Scientists may have found mechanism behind cognitive decline in aging

#179

Post by CodeSgt »

xkbarkar wrote: post #153
swalsh wrote: post #16

I've noticed a cognitive decline in myself the past couple years. I'm in my mid 30's though so I assume it's more related to long covid. One of the biggest side effects of long covid for me was horrible insomnia, which was killer. The insomnia is mostly gone, but I'm still not my previous cognitive self. It's terrifying to be honest.

How did this go to the top vote? Brings nothing about the article just dubious personal long covid claims. HN please stop upvoting this nonsense. Already the second and third answers are HN quality. This is r/covid commentary. Does not belong here.

What makes you the arbiter of discussion? The article is about cognitive decline, this is an anecdote about personal cognitive decline that they believe happened to be caused by covid.

If you think every comment with a personal anecdote tangentially related to the article is “nonsense” and “r/x” material then you must be constantly frustrated by nearly every HN comments section of sufficient length.

Re: Scientists may have found mechanism behind cognitive decline in aging

#180

Post by koheripbal »

herval wrote: post #136
swalsh wrote: post #16

I've noticed a cognitive decline in myself the past couple years. I'm in my mid 30's though so I assume it's more related to long covid. One of the biggest side effects of long covid for me was horrible insomnia, which was killer. The insomnia is mostly gone, but I'm still not my previous cognitive self. It's terrifying to be honest.

I had the same after COVID. Took me many months to start feeling functional again. Any time I tried to think about something, it'd just... noise out? First 2-3 months were just awful I went to a neurologist who said there's tons of people coming in with the same complaint after COVID, and since there's no literature on that yet, he couldn't really do anything. It gets better.

I wonder how many people just fell into alcohol, isolation induced depression, sedentary lifestyle, weight gain, etc... and that their health decline had nothing to do with COVID.

That's the issue with these anecdotes

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