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Scientists may have found mechanism behind cognitive decline in aging

news.cuanschutz.edu

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Re: Scientists may have found mechanism behind cognitive decline in aging

#21

Post by PaulKeeble »

Aaargh20318 wrote: post #7
Etheryte wrote: post #4

...in mice.

Due to the way medication is developed, we basically only end up with medicine that works on humans + at least one other species. I wonder how many medications we have missed out on that would have worked on humans but never got to the human trial stage because it doesn’t work in any of the animal models we use.

And a condition we can induce in another animal. If we can't cause it in another animal then we can't test a drug against it. There are a lot of diseases that can make no progress under this model which we can not induce in animals or humans.

Re: Scientists may have found mechanism behind cognitive decline in aging

#24

Post by rapsey »

swalsh wrote: post #16

I've noticed a cognitive decline in myself the past couple years. I'm in my mid 30's though so I assume it's more related to long covid. One of the biggest side effects of long covid for me was horrible insomnia, which was killer. The insomnia is mostly gone, but I'm still not my previous cognitive self. It's terrifying to be honest.

Are you taking vitamin d? If not you absolutely should. Magnesium at the same time as D3 and then glycine and another dose of magnesium before bed. This is the magic formula for me.

Re: Scientists may have found mechanism behind cognitive decline in aging

#25

Post by freehorse »

> Researchers using mouse models found that altering the CaMKII brain protein caused similar cognitive effects as those that happen through normal aging.

This should be the title of the article. Honestly these supposedly dissemination articles do not offer much more than reading the abstract or skimming a bit through the article itself.

https://www.science.org/doi/10.1126/scisignal.ade5892

Re: Scientists may have found mechanism behind cognitive decline in aging

#26

Post by fnordpiglet »

The article suggests that decline in nitric oxide availability as you age under pins the effect studied. Citrulline has been found to be an effective route for improving nitric oxide levels by synthesizing into arginine, which is destroyed in the gut while citrulline is not and readily converts into arginine.

https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/j.1...

… in humans

Re: Scientists may have found mechanism behind cognitive decline in aging

#27

Post by nottorp »

pja wrote: post #18
swalsh wrote: post #16

I've noticed a cognitive decline in myself the past couple years. I'm in my mid 30's though so I assume it's more related to long covid. One of the biggest side effects of long covid for me was horrible insomnia, which was killer. The insomnia is mostly gone, but I'm still not my previous cognitive self. It's terrifying to be honest.

Quality of sleep makes a huge difference to your mental faculties. If you could bottle it, the effect would be a multi, multi $billion drug.

Exercise tends to help.

Re: Scientists may have found mechanism behind cognitive decline in aging

#28

Post by amelius »

rapsey wrote: post #24
swalsh wrote: post #16

I've noticed a cognitive decline in myself the past couple years. I'm in my mid 30's though so I assume it's more related to long covid. One of the biggest side effects of long covid for me was horrible insomnia, which was killer. The insomnia is mostly gone, but I'm still not my previous cognitive self. It's terrifying to be honest.

Are you taking vitamin d? If not you absolutely should. Magnesium at the same time as D3 and then glycine and another dose of magnesium before bed. This is the magic formula for me.

If you take a lot of vitamin d, make sure you also take vitamin k.

Just a random source here because I'm too lazy:

https://www.balancedwellbeinghealthcare.com/are-you-taking-v...

> Because vitamin D is so good at improving calcium levels, by taking it alone you could be working to increase the calcification of your arteries instead of strengthening your bones so make sure to include K2 in your vitamin D supplement regimen!

Re: Scientists may have found mechanism behind cognitive decline in aging

#29

Post by PrimeMcFly »

swalsh wrote: post #16

I've noticed a cognitive decline in myself the past couple years. I'm in my mid 30's though so I assume it's more related to long covid. One of the biggest side effects of long covid for me was horrible insomnia, which was killer. The insomnia is mostly gone, but I'm still not my previous cognitive self. It's terrifying to be honest.

> I'm in my mid 30's though so I assume it's more related to long covid.

Much more likely to just be aging. You're not too old for it.

Re: Scientists may have found mechanism behind cognitive decline in aging

#30

Post by withinboredom »

hollerith wrote: post #15
withinboredom wrote: post #9

Earlier quoted context omitted.

IIRC, brain cells don’t divide, so “random DNA changes” don’t apply, at least not in the way it would in the rest of the body. I could be totally wrong, I’m not a brain scientist.

A cell still needs its DNA (to make proteins among other things) even when it is not dividing.

They asked about “compared to the rest of the body” and I was explaining (to the best of my knowledge) why it doesn’t work the same.
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