Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

Scientists may have found mechanism behind cognitive decline in aging

news.cuanschutz.edu

Post reply on HN
Print view View original

41–50 of 314 posts

Re: Scientists may have found mechanism behind cognitive decline in aging

#41

Post by prox »

amelius wrote: post #28
rapsey wrote: post #24

Earlier quoted context omitted.

Are you taking vitamin d? If not you absolutely should. Magnesium at the same time as D3 and then glycine and another dose of magnesium before bed. This is the magic formula for me.

If you take a lot of vitamin d, make sure you also take vitamin k. Just a random source here because I'm too lazy: https://www.balancedwellbeinghealthcare.com/are-you-taking-v... > Because vitamin D is so good at improving calcium levels, by taking it alone you could be working to increase the calcification of your arteries instead of strengthening your bones so make sure to include K2 in your vitamin D supplement re…

Please note that overtaking vitamin D is unhealthy as well. It’s a hormone and I believe taking too much is damaging to the liver. But supplemental and when having a lack of Sun is probably a good balance.

But if you can be in the sun your skin can make vitamin D.

Re: Scientists may have found mechanism behind cognitive decline in aging

#42

Post by ThinkBeat »

The brain is an extremely complicated

I think they may have found one mechanism or one part behind the cognitive decline in aging.

I am certain there are several different processes that contribute to it and finding all of them and then mitigating those may have side effects in other parts of the brain.

I have an extremely speculative and not based on science that the brain simply is not meant to function forever.

We extend life in various ways, and we get better at it. Perhaps in a couple of decades people will live (be kept alive) for 100 years on average. (well those who live in a country where such medication and treatment is available and at some level affordable)

But human evolution has not caught up with the prolonged life span since living that long has been an exception for 300.000 years and looking farther back in evolution probably millions of years

Re: Scientists may have found mechanism behind cognitive decline in aging

#43

Post by jeffybefffy519 »

submeta wrote: post #35

[flagged]

I really want to know, why don't we all supplement with L-arginine long term? Time-release capsules are available and I have taken for numerous issues like RSI to great success. Whats the downside to long term usage?

Re: Scientists may have found mechanism behind cognitive decline in aging

#44

Post by bendbro »

swalsh wrote: post #16

I've noticed a cognitive decline in myself the past couple years. I'm in my mid 30's though so I assume it's more related to long covid. One of the biggest side effects of long covid for me was horrible insomnia, which was killer. The insomnia is mostly gone, but I'm still not my previous cognitive self. It's terrifying to be honest.

After my startup failed and I broke up with my girlfriend, my cognition massively changed: I was less creative, less quick, and I could see it reduce my ability to code. Otherwise, I lost libido, had paranoia in social interaction, and alcohol or marijuana would cause me paranoia. When I would ride my motorcycle on curvy roads, or when I would play a racing game or read a book, I couldn't get into a flow anymore. Thinking about activities would stress me to the point that I would avoid doing anything.

After a number of years I feel normal, and I think it was due primarily to finding and sticking to a routine. The routine involves little things like watering plants and making coffee, and I just do them every day without thinking. Otherwise it includes exercise, sleep, chores, work, and procrastination.

Re: Scientists may have found mechanism behind cognitive decline in aging

#45

Post by bendbro »

swalsh wrote: post #36
nottorp wrote: post #27

Earlier quoted context omitted.

Exercise tends to help.

My kids have started taking swim lessons at the Y, so i've been sneaking up stairs to run a mile during their lesson. I've thought about strength training etc, but I have no idea what i'm doing on those machines. Can't say I feel any different, but it is enjoyable.

Just try some pushups, dips, pull ups, and sit ups. Just do a set of a few types each day until your strength is depleted and you will see strength gains.

Re: Scientists may have found mechanism behind cognitive decline in aging

#46

Post by LoganDark »

belter wrote: post #40
Etheryte wrote: post #4

...in mice.

Maybe if mice did Math, they could avoid this cognitive decline people talk about.. https://math.stackexchange.com/questions/1059235/great-contr...

I misread your comment as "meth" the first time and I was like... well I guess that could theoretically help. You know, aside from the neurotoxicity of meth.

I take dextroamphetamine for ADHD, and even though it's a lot less toxic than meth is, I still have to take frequent magnesium supplements or else my magnesium levels totally dive (confirmed by blood tests).

Re: Scientists may have found mechanism behind cognitive decline in aging

#47

Post by scrollaway »

submeta wrote: post #35

[flagged]

> I want to stress that I'm no expert

No kidding. (Sorry, but I work with GPT more than enough every day to recognize its style)

Not to diminish the value of the comment itself, but please don't mislead people.

Re: Scientists may have found mechanism behind cognitive decline in aging

#48

Post by grumblehound »

bendbro wrote: post #44
swalsh wrote: post #16

I've noticed a cognitive decline in myself the past couple years. I'm in my mid 30's though so I assume it's more related to long covid. One of the biggest side effects of long covid for me was horrible insomnia, which was killer. The insomnia is mostly gone, but I'm still not my previous cognitive self. It's terrifying to be honest.

After my startup failed and I broke up with my girlfriend, my cognition massively changed: I was less creative, less quick, and I could see it reduce my ability to code. Otherwise, I lost libido, had paranoia in social interaction, and alcohol or marijuana would cause me paranoia. When I would ride my motorcycle on curvy roads, or when I would play a racing game or read a book, I couldn't get into a flow anymore. Thi…

I recently quit my dev job because it was too stressful and I was burning out. I seemed to almost instantly get better at thrashing my motorbike in the twisties... I'm not sure why exactly but it feels like a weight was lifted and it just allowed me to focus and enjoy being in the moment a bit more.

Re: Scientists may have found mechanism behind cognitive decline in aging

#49

Post by retSava »

swalsh wrote: post #16

I've noticed a cognitive decline in myself the past couple years. I'm in my mid 30's though so I assume it's more related to long covid. One of the biggest side effects of long covid for me was horrible insomnia, which was killer. The insomnia is mostly gone, but I'm still not my previous cognitive self. It's terrifying to be honest.

Have a blood work checkup. Ensure you'll check vitamin and mineral levels, perhaps most notably vit D and iron. Also check ferritin and transferrin saturation (aids in pinpointing hemochromatosis ie iron overload, which for many leads to brain fog and fatigue and often shows up your age). Exercise regularly.

Re: Scientists may have found mechanism behind cognitive decline in aging

#50

Post by RobotToaster »

vasco wrote: post #23
RobotToaster wrote: post #17

So, how do we stop it?

If you die early enough you should be able to prevent any cognitive decline, or at least experience it all at once and very fast.

Hmm, anything with fewer side effects?
Post reply on HN