Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

Metformin shown to prevent long Covid

cidrap.umn.edu

Post reply on HN
Print view View original

161–170 of 195 posts

Re: Metformin shown to prevent long Covid

#161

Post by peteradio »

ceedan wrote: post #155
peteradio wrote: post #153

Earlier quoted context omitted.

How many had pre-diabetes? Type-2 is a pretty serious diagnosis above a pretty significant threshold. Long-covid as defined can be somewhat marginal in characteristic.

The paper doesn't say, but I would imagine it was very high. Googling the statistic says 1/3 of Americans have pre-diabetes.

So I guess what I'm wondering is, how do we know we are treating lingering covid rather than pre-diabetes symptoms? Pre-diabetes is not symptomless and metformin is prescribed off-label to manage those symptoms. How many pre-diabetes symptoms overlap with long-covid classification?

Re: Metformin shown to prevent long Covid

#162

Post by JPws_Prntr_Fngr »

anonymouskimmer wrote: post #130
r0l1 wrote: post #76

Earlier quoted context omitted.

Can't say too much about it. Didn't really follow the whole Covid discussion and just continued my lifestyle. Eating healthy (fresh self-made food), doing sports and looking after a good mental state. Family and my circle did the same. Friends who have been vaccinated got Covid several times. But are also good now... My grandmom (89 years), also unvaccinated, didn't get Covid. Her sister got it (vaccinated). Both hea…

Attitudes like yours are why it kept spreading instead of petering out. I'm not saying that people need to get vaccinated, but I'm god damn sick of people not caring about spreading disease, whether vaccinated, or not. Humanity, as a whole, is in a war with disease. We don't need collaborators. All it takes for evil to triumph is for good people to do nothing. https://www.nature.com/articles/d41586-022-00319-9 > Heal…

[flagged]

Re: Metformin shown to prevent long Covid

#163

Post by psychphysic »

subsubzero wrote: post #157

I had long covid back in early 2022. It was not fun, despite being fully vaccinated and being extremely fit(run 20+ miles a week etc). It took me 3 months to shake the symptoms and I tried everything. Vitamin B IV injection(helped a little with splitting headaches I constantly had a month after covid). Vitamin D 5000iu daily, Fish Oil supplements, Zinc(had to stop from stomach issues), even tried MSM with Tumeric. I…

I don't think 3 months to recover from COVID is considered long COVID.

12 weeks to recover from a viral illness, is unfortunately not special.

I believe most definitions are 12weeks+

WHO definition is 3 months from onset with symptoms for at least 2 months (so there could be a brief recover period after which symptoms return).

If it took you "3 months to shake the symptoms" you wouldn't meet WHO criteria.

Re: Metformin shown to prevent long Covid

#164

Post by shipscode »

sBqQu3U0wH wrote: post #57
petecooper wrote: post #52

>Now that we're in 2023, and pretty much everyone is either multiply-vaccinated or has had COVID I'm a facilitator for a men's mental health talking group in my county. Sample size is small and not indicative, but there are a few people who are anti-vaccination, have continued to eschew popular science in favour of their trusted researchers, and are now assigning blame to almost any other person's illnesses as caused…

Well, I developed heart problems just after getting vaccinated so it's pretty hard for me not to agree when people speculate that some sudden death, severe illness or whatever at a young age may be due to the vaccination. I know I am biased, but how can I not be?

At least you're alive, I've watched family members of loved ones die. Vaccine -> Full Body Rash -> Organ Failure within 2 months of the booster.

Between that and the "totally not caused by the vaccine" friends who had blood clots, gallbladder and appendix removals, etc... all in their late 20s.

All I'll say is I'm happy I never got it.

Re: Metformin shown to prevent long Covid

#165

Post by dxhdr »

anonymouskimmer wrote: post #152
r0l1 wrote: post #151

Earlier quoted context omitted.

Sorry, but I have a complete different position on this topic. However I respect your opinion.

My opinion doesn't lead to harm to other people, so you'll understand why I don't respect yours. Your right to swing your infected spittle ends where other people's mouths and noses begin.

> My opinion doesn't lead to harm to other people, so you'll understand why I don't respect yours. Your right to swing your infected spittle ends where other people's mouths and noses begin.

Don't you have the ability to stay home and avoid breathing near other humans if you're so concerned? I'm confused by that statement. How is demanding reduced freedom for him more just than simply exercising your own?

Re: Metformin shown to prevent long Covid

#166

Post by ceedan »

peteradio wrote: post #161
ceedan wrote: post #155

Earlier quoted context omitted.

The paper doesn't say, but I would imagine it was very high. Googling the statistic says 1/3 of Americans have pre-diabetes.

So I guess what I'm wondering is, how do we know we are treating lingering covid rather than pre-diabetes symptoms? Pre-diabetes is not symptomless and metformin is prescribed off-label to manage those symptoms. How many pre-diabetes symptoms overlap with long-covid classification?

> The primary method for ascertaining long COVID was participant-reported receipt of a long COVID diagnosis from a medical provider. Participants were asked whether a medical provider had given them a diagnosis of long COVID in follow-up surveys on days 180, 210, 240, 270, and 300.

See the outcomes section. Also, read the paper.

Re: Metformin shown to prevent long Covid

#167

Post by [deleted] »

Fomite wrote: post #146
bandyaboot wrote: post #117

Earlier quoted context omitted.

Not to mention the fact that the risk of developing a serious heart condition after getting Covid is massively higher than for getting the vaccine—including myocarditis. Though I would like to know what that comparison looks like if were only considering young, healthy people. That data still seems difficult to come across. But, I don't think there's any reason at this point to think that the relative risk of vaccine…

Having done that comparison, really the only group where the vaccine wasn't protective against myocarditis (let alone everything else) was young men. And even then, it was more "Ehhh...?" The myocarditis caused was also, generally speaking, milder than that caused by infection.

[deleted]

Re: Metformin shown to prevent long Covid

#168

Post by mlyle »

shipscode wrote: post #164
sBqQu3U0wH wrote: post #57

Earlier quoted context omitted.

Well, I developed heart problems just after getting vaccinated so it's pretty hard for me not to agree when people speculate that some sudden death, severe illness or whatever at a young age may be due to the vaccination. I know I am biased, but how can I not be?

At least you're alive, I've watched family members of loved ones die. Vaccine -> Full Body Rash -> Organ Failure within 2 months of the booster. Between that and the "totally not caused by the vaccine" friends who had blood clots, gallbladder and appendix removals, etc... all in their late 20s. All I'll say is I'm happy I never got it.

> appendix removals

Pretty odd to cite something that has always mostly affected people under 30.

Re: Metformin shown to prevent long Covid

#169

Post by spondylosaurus »

dxhdr wrote: post #165
anonymouskimmer wrote: post #152

Earlier quoted context omitted.

My opinion doesn't lead to harm to other people, so you'll understand why I don't respect yours. Your right to swing your infected spittle ends where other people's mouths and noses begin.

> My opinion doesn't lead to harm to other people, so you'll understand why I don't respect yours. Your right to swing your infected spittle ends where other people's mouths and noses begin. Don't you have the ability to stay home and avoid breathing near other humans if you're so concerned? I'm confused by that statement. How is demanding reduced freedom for him more just than simply exercising your own?

Why didn't we let Typhoid Mary roam free and simply tell other people to avoid her if they didn't want to get typhoid fever?

Come on now.

Re: Metformin shown to prevent long Covid

#170

Post by anonymouskimmer »

amluto wrote: post #156
anonymouskimmer wrote: post #130

Earlier quoted context omitted.

Attitudes like yours are why it kept spreading instead of petering out. I'm not saying that people need to get vaccinated, but I'm god damn sick of people not caring about spreading disease, whether vaccinated, or not. Humanity, as a whole, is in a war with disease. We don't need collaborators. All it takes for evil to triumph is for good people to do nothing. https://www.nature.com/articles/d41586-022-00319-9 > Heal…

> Attitudes like yours are why it kept spreading instead of petering out. Defining “why” can be a complex exercise, but let’s take a very simple approach: if there were not attitudes like the GP and everyone who could got vaccinated, would COVID have petered out? I don’t think so. It’s plausible that, if enough production capacity had existed to rapidly vaccinate, say, 85% of the world population, evenly distributed,…

I didn't write "vaccinate". I wrote: "I'm god damn sick of people not caring about spreading disease, whether vaccinated, or not."

Since you aren't discussing the topic I wrote about, I won't reply further.

Post reply on HN