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Metformin shown to prevent long Covid

cidrap.umn.edu

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Re: Metformin shown to prevent long Covid

#111

Post by [deleted] »

rbanffy wrote: post #74
sBqQu3U0wH wrote: post #57

Earlier quoted context omitted.

Well, I developed heart problems just after getting vaccinated so it's pretty hard for me not to agree when people speculate that some sudden death, severe illness or whatever at a young age may be due to the vaccination. I know I am biased, but how can I not be?

There is a small risk of developing myocarditis after being vaccinated, but the risk of dying of COVID in the US, for instance, was of 1.1% after being diagnosed. I’m really sorry you are going through this. People didn’t have time to better test the vaccines to ensure their safety before having to use them to prevent massive loss of life due to the disease. Perhaps we’ll find ways to alleviate the issues the vaccine…

[deleted]

Re: Metformin shown to prevent long Covid

#114

Post by hilbertseries »

darkerside wrote: post #66
hilbertseries wrote: post #47

Earlier quoted context omitted.

You’re not paying attention if you think this is the first evidence of long covid. There’s been significant strides towards understanding long covid in terms of microclots and viral persistence. https://cardiab.biomedcentral.com/articles/10.1186/s12933-02... For this pathology long covid can be treated with so called triple therapy for instance https://medhelpclinics.com/uploads/files/anticoagulant-tripl...

Parent is saying it's the first evidence of TREATMENT. Incidentally, my bet is that many other viruses and bacteria have similar post acute symptoms. I wonder if these can also be measured and treated, perhaps even with metformin. I wonder how much of metformin's magical anti aging capabilities are actually due to fighting off latent infections.

Triple therapy is a treatment that proceeds it. Metformin isn’t a treatment, it’s a prophylactic.

Re: Metformin shown to prevent long Covid

#115

Post by superkuh »

gnicholas wrote: post #25

TLDR: > By day 300 of follow-up, 93 (8.3%) of 1,126 participants said they had received a diagnosis of long COVID by a provider. The cumulative incidence of long COVID by day 300 in those who took a 14-day course of metformin was 6.3% (95% confidence interval [CI], 4.2 to 8.2) compared to 10.4% (7.8 to 12.9) in the placebo group, or 39.4% lower. Interestingly, half of the participants in the study (which took place s…

If Metformin reduces the viral load, it probably does so throughout the entire body. Whereas intramuscular vacccination leads to good protection against serious disease through humoral (body serum) immunity, it does not, unfortunately, provide significant protection to the other immune compartments like the upper respiratory mucosal layer (served by a different set of antibodies than the humoral).

So this is good. This (and paxlovid) can help protect those remaining unprotected tissues of the upper respiratory that tend to be the first infected. It should be a good temporary mitigation until the USA and other countries approve of good intranasal sars-cov-2 vaccine boosters like India has (Innovac).

Re: Metformin shown to prevent long Covid

#116

Post by Slava_Propanei »

kramerger wrote: post #72
carlmr wrote: post #49

Earlier quoted context omitted.

>Now that we're in 2023, and pretty much everyone is either multiply-vaccinated ~or~ and has had COVID multiple times Isn't this the most common demographic?

Not in places were vaccine rollout was quick and frictionless with good coverage, thus reducing probability of transmission of the main strain and early mutations. I think a lot of people in Northern Europe have either never had covid or had a mild possibly unnoticeable infection

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Re: Metformin shown to prevent long Covid

#117

Post by bandyaboot »

rbanffy wrote: post #74
sBqQu3U0wH wrote: post #57

Earlier quoted context omitted.

Well, I developed heart problems just after getting vaccinated so it's pretty hard for me not to agree when people speculate that some sudden death, severe illness or whatever at a young age may be due to the vaccination. I know I am biased, but how can I not be?

There is a small risk of developing myocarditis after being vaccinated, but the risk of dying of COVID in the US, for instance, was of 1.1% after being diagnosed. I’m really sorry you are going through this. People didn’t have time to better test the vaccines to ensure their safety before having to use them to prevent massive loss of life due to the disease. Perhaps we’ll find ways to alleviate the issues the vaccine…

Not to mention the fact that the risk of developing a serious heart condition after getting Covid is massively higher than for getting the vaccine—including myocarditis. Though I would like to know what that comparison looks like if were only considering young, healthy people. That data still seems difficult to come across. But, I don't think there's any reason at this point to think that the relative risk of vaccine induced myocarditis vs covid induced myocarditis is significantly different in that demographic than any other.

Re: Metformin shown to prevent long Covid

#118

Post by Slava_Propanei »

xattt wrote: post #85
gnicholas wrote: post #25

TLDR: > By day 300 of follow-up, 93 (8.3%) of 1,126 participants said they had received a diagnosis of long COVID by a provider. The cumulative incidence of long COVID by day 300 in those who took a 14-day course of metformin was 6.3% (95% confidence interval [CI], 4.2 to 8.2) compared to 10.4% (7.8 to 12.9) in the placebo group, or 39.4% lower. Interestingly, half of the participants in the study (which took place s…

If the inconvenience of having a vaccine are a turn-off for this demographic, I can’t imagine that GI distress (i.e. urgency) associated with metformin would be tolerable either.

[dead]

Re: Metformin shown to prevent long Covid

#119

Post by thatguy0900 »

superkuh wrote: post #115
gnicholas wrote: post #25

TLDR: > By day 300 of follow-up, 93 (8.3%) of 1,126 participants said they had received a diagnosis of long COVID by a provider. The cumulative incidence of long COVID by day 300 in those who took a 14-day course of metformin was 6.3% (95% confidence interval [CI], 4.2 to 8.2) compared to 10.4% (7.8 to 12.9) in the placebo group, or 39.4% lower. Interestingly, half of the participants in the study (which took place s…

If Metformin reduces the viral load, it probably does so throughout the entire body. Whereas intramuscular vacccination leads to good protection against serious disease through humoral (body serum) immunity, it does not, unfortunately, provide significant protection to the other immune compartments like the upper respiratory mucosal layer (served by a different set of antibodies than the humoral). So this is good. Th…

I honestly can't imagine taking more covid vaccines. I haven't even thought about covid for a year now.

Re: Metformin shown to prevent long Covid

#120

Post by sBqQu3U0wH »

notacoward wrote: post #77
sBqQu3U0wH wrote: post #57

Earlier quoted context omitted.

Well, I developed heart problems just after getting vaccinated so it's pretty hard for me not to agree when people speculate that some sudden death, severe illness or whatever at a young age may be due to the vaccination. I know I am biased, but how can I not be?

> may be due to the vaccination Emphasis on may , or might. Your experience is certainly valid, and I'm sorry you have to go through this, but it's still a sample of one with no theory of causation. If a certain percentage of people are vaccinated, and a certain percentage of people develop heart problems regardless of vaccination, a few of those people will develop those problems immediately after vaccination. Such…

>predisposition

Honestly, I didn't have any strong opinions and just did what everyone else did. Moreover, it was inconvenient that I could not enter to a grocery store without proof of vaccination so there is that. I am 26. I do not and never smoked, do not drink alcohol, maintain a healthy diet (do not eat sweets (except for dark chocolate sometimes) or anything that has lots of sugar, avoid highly processed foods, eat a decent amount of fruits, vegetables, nuts, fish, whatever), exercise regularly and never had any notable health problems prior to vaccine, I am not overweight not underweight. To the best of my knowledge, I never had Covid either.

Sure, I do not disagree that predisposition does not exist in such cases as you described, but I just feel bitter and miserable.

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