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Metformin shown to prevent long Covid

cidrap.umn.edu

61–70 of 195 posts

Re: Metformin shown to prevent long Covid

#61
post #23

In my extended network of 1000+ people, I've heard of 2 that may have "long covid". Are people's experiences different?

I suppose there are business connections among those 1000+, and I have a policy of never telling a business contact anything about my health (except "I'm on sick leave", if necessary). I suppose I'm not the only on doing that, so you most likely underestimate the occurrences.

Re: Metformin shown to prevent long Covid

#62
post #23

In my extended network of 1000+ people, I've heard of 2 that may have "long covid". Are people's experiences different?

Yes, I know of friends and coworkers who have had to change career because they couldn't do their old job anymore. This after a year long recovery. They aren't happy about it, they really want to do their old job, if only they could. Then there are a few more who where home sick for 1 or 2 months. They all seem to have recovered.

Re: Metformin shown to prevent long Covid

#63

>Now that we're in 2023, and pretty much everyone is either multiply-vaccinated or has had COVID I'm a facilitator for a men's mental health talking group in my county. Sample size is small and not indicative, but there are a few people who are anti-vaccination, have continued to eschew popular science in favour of their trusted researchers, and are now assigning blame to almost any other person's illnesses as caused…

The downvotes could be because your comment doesn’t add to the discussion but rather seems to be needlessly stoking some flames…

Re: Metformin shown to prevent long Covid

#64
post #63

>Now that we're in 2023, and pretty much everyone is either multiply-vaccinated or has had COVID I'm a facilitator for a men's mental health talking group in my county. Sample size is small and not indicative, but there are a few people who are anti-vaccination, have continued to eschew popular science in favour of their trusted researchers, and are now assigning blame to almost any other person's illnesses as caused…

The downvotes could be because your comment doesn’t add to the discussion but rather seems to be needlessly stoking some flames…

That's fair, I can see that. That was not my intention.

Re: Metformin shown to prevent long Covid

#65
post #37

I wonder if other AMPK activators such as Berberine and Jiaogulan have the same effect.

Is there a good explanation of the mechanism of action? Metformin is also a Mitochondrial Complex 1 inhibitor, so I would be curious about Annonaceous acetogenins.

Re: Metformin shown to prevent long Covid

#66
post #46

Earlier quoted context omitted.

I think you're misinterpreting it. The full quote: > Long Covid is looking less like a cloudy mass of speculation and shoulder-shrugging, and more like a problem that medical science can start to unravel, using the tools we already have: > When a disease is too poorly defined, it follows that it is almost impossible to modify either the incidence of that disease or the distribution of its outcomes—that is, unless the…

You’re not paying attention if you think this is the first evidence of long covid. There’s been significant strides towards understanding long covid in terms of microclots and viral persistence. https://cardiab.biomedcentral.com/articles/10.1186/s12933-02... For this pathology long covid can be treated with so called triple therapy for instance https://medhelpclinics.com/uploads/files/anticoagulant-tripl...

Parent is saying it's the first evidence of TREATMENT.

Incidentally, my bet is that many other viruses and bacteria have similar post acute symptoms. I wonder if these can also be measured and treated, perhaps even with metformin. I wonder how much of metformin's magical anti aging capabilities are actually due to fighting off latent infections.

Re: Metformin shown to prevent long Covid

#67
post #23

In my extended network of 1000+ people, I've heard of 2 that may have "long covid". Are people's experiences different?

People suffering from long covid certainly have a different experience. There's a range from "things smelled differently for a few months" to "I'm now functionally disabled due to fatigue". But without biomarkers that say you have this thing, it just looks like you're being lazy. So why would anybody tell you they have it and be judged?

Re: Metformin shown to prevent long Covid

#68
post #46

Earlier quoted context omitted.

I think you're misinterpreting it. The full quote: > Long Covid is looking less like a cloudy mass of speculation and shoulder-shrugging, and more like a problem that medical science can start to unravel, using the tools we already have: > When a disease is too poorly defined, it follows that it is almost impossible to modify either the incidence of that disease or the distribution of its outcomes—that is, unless the…

You’re not paying attention if you think this is the first evidence of long covid. There’s been significant strides towards understanding long covid in terms of microclots and viral persistence. https://cardiab.biomedcentral.com/articles/10.1186/s12933-02... For this pathology long covid can be treated with so called triple therapy for instance https://medhelpclinics.com/uploads/files/anticoagulant-tripl...

[deleted]

Re: Metformin shown to prevent long Covid

#69
One thing metformin does is occasionally encourage cells to burn excess energy rather than store it. This may lead to extra cellular repair processes. I heard cancer rates were lower in metformin users and could extend life. Had my doc prescribe it to me 5 or so years ago.

I take it daily. There were mild GI side effects and weight loss at first, but my body adjusted and now it is BAU.

Haven't changed my lifestyle, can't know if it has made me more healthful. I still get colds and flu maybe once every other year.

Had a vaccine injury scare after the second jab. My health has been down since, can't know if Metformin is helping or hurting that situation - hopefully in the background helping me heal.

Re: Metformin shown to prevent long Covid

#70

Earlier quoted context omitted.

TL; DR Do not take if you're trying to impregnate someone. (Is that the right term? Get pregnant?)

"impregnate" is not wrong per-se, but it is weird in placing the emphasis on only one of the two people required. Usually you'd say something like "trying for a child", I believe.

It's not weird in this case, because the drug specifically affects male sperm, and it's the man who impregnates the woman.
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