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Metformin shown to prevent long Covid

cidrap.umn.edu

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Re: Metformin shown to prevent long Covid

#151

Post by r0l1 »

anonymouskimmer wrote: post #130
r0l1 wrote: post #76

Earlier quoted context omitted.

Can't say too much about it. Didn't really follow the whole Covid discussion and just continued my lifestyle. Eating healthy (fresh self-made food), doing sports and looking after a good mental state. Family and my circle did the same. Friends who have been vaccinated got Covid several times. But are also good now... My grandmom (89 years), also unvaccinated, didn't get Covid. Her sister got it (vaccinated). Both hea…

Attitudes like yours are why it kept spreading instead of petering out. I'm not saying that people need to get vaccinated, but I'm god damn sick of people not caring about spreading disease, whether vaccinated, or not. Humanity, as a whole, is in a war with disease. We don't need collaborators. All it takes for evil to triumph is for good people to do nothing. https://www.nature.com/articles/d41586-022-00319-9 > Heal…

Sorry, but I have a complete different position on this topic. However I respect your opinion.

Re: Metformin shown to prevent long Covid

#152

Post by anonymouskimmer »

r0l1 wrote: post #151
anonymouskimmer wrote: post #130

Earlier quoted context omitted.

Attitudes like yours are why it kept spreading instead of petering out. I'm not saying that people need to get vaccinated, but I'm god damn sick of people not caring about spreading disease, whether vaccinated, or not. Humanity, as a whole, is in a war with disease. We don't need collaborators. All it takes for evil to triumph is for good people to do nothing. https://www.nature.com/articles/d41586-022-00319-9 > Heal…

Sorry, but I have a complete different position on this topic. However I respect your opinion.

My opinion doesn't lead to harm to other people, so you'll understand why I don't respect yours. Your right to swing your infected spittle ends where other people's mouths and noses begin.

Re: Metformin shown to prevent long Covid

#153

Post by peteradio »

ceedan wrote: post #148
p-o wrote: post #141

[Deleted]

Both points are not true. Participants section of the paper > We excluded people who were already taking one of the study medications or who had already received a COVID-19 treatment with Emergency Use Authorization by the US Food and Drug Administration. Baseline characteristics table, Medical history section > Only 17 (1.5%) of the participants had diabetes.

How many had pre-diabetes? Type-2 is a pretty serious diagnosis above a pretty significant threshold. Long-covid as defined can be somewhat marginal in characteristic.

Re: Metformin shown to prevent long Covid

#154

Post by poorbutdebtfree »

sBqQu3U0wH wrote: post #57
petecooper wrote: post #52

>Now that we're in 2023, and pretty much everyone is either multiply-vaccinated or has had COVID I'm a facilitator for a men's mental health talking group in my county. Sample size is small and not indicative, but there are a few people who are anti-vaccination, have continued to eschew popular science in favour of their trusted researchers, and are now assigning blame to almost any other person's illnesses as caused…

Well, I developed heart problems just after getting vaccinated so it's pretty hard for me not to agree when people speculate that some sudden death, severe illness or whatever at a young age may be due to the vaccination. I know I am biased, but how can I not be?

I know it feels like the entire medical and scientific establishments are against you, but please know that you're not alone, not by a long shot.

Re: Metformin shown to prevent long Covid

#155

Post by ceedan »

peteradio wrote: post #153
ceedan wrote: post #148

Earlier quoted context omitted.

Both points are not true. Participants section of the paper > We excluded people who were already taking one of the study medications or who had already received a COVID-19 treatment with Emergency Use Authorization by the US Food and Drug Administration. Baseline characteristics table, Medical history section > Only 17 (1.5%) of the participants had diabetes.

How many had pre-diabetes? Type-2 is a pretty serious diagnosis above a pretty significant threshold. Long-covid as defined can be somewhat marginal in characteristic.

The paper doesn't say, but I would imagine it was very high. Googling the statistic says 1/3 of Americans have pre-diabetes.

Re: Metformin shown to prevent long Covid

#156

Post by amluto »

anonymouskimmer wrote: post #130
r0l1 wrote: post #76

Earlier quoted context omitted.

Can't say too much about it. Didn't really follow the whole Covid discussion and just continued my lifestyle. Eating healthy (fresh self-made food), doing sports and looking after a good mental state. Family and my circle did the same. Friends who have been vaccinated got Covid several times. But are also good now... My grandmom (89 years), also unvaccinated, didn't get Covid. Her sister got it (vaccinated). Both hea…

Attitudes like yours are why it kept spreading instead of petering out. I'm not saying that people need to get vaccinated, but I'm god damn sick of people not caring about spreading disease, whether vaccinated, or not. Humanity, as a whole, is in a war with disease. We don't need collaborators. All it takes for evil to triumph is for good people to do nothing. https://www.nature.com/articles/d41586-022-00319-9 > Heal…

> Attitudes like yours are why it kept spreading instead of petering out.

Defining “why” can be a complex exercise, but let’s take a very simple approach: if there were not attitudes like the GP and everyone who could got vaccinated, would COVID have petered out? I don’t think so.

It’s plausible that, if enough production capacity had existed to rapidly vaccinate, say, 85% of the world population, evenly distributed, that it would have worked. But getting a uniform 85% was never in the cards, and, starting some time in 2021, the vaccine was nowhere near effective enough for a two-dose series to suppress transmission even with 100% coverage.

Sorry, but the idea of eliminating Covid with the vaccines we have was a nice fantasy, but it was not going to happen.

(If the vaccine were much better and had good worldwide coverage, then maybe. The smallpox vaccine was good enough. The measles and chickenpox vaccines are plausibly good enough. The oral polio vaccine might be good enough, but I have serious doubts that the strategy with which it’s used is actually appropriate. Somehow there does not appear to be community transmission of polio in New York right now, and I’m a bit surprised.

(People under about 23 years old in the US have generally received the injectable polio vaccine, not the oral vaccine. The injectable vaccine seems to be generally considered inadequate to prevent transmission. Maybe the under 23 year old NY population coupled with modern hygiene is not actually able to sustain an outbreak?)

Re: Metformin shown to prevent long Covid

#157

Post by subsubzero »

I had long covid back in early 2022. It was not fun, despite being fully vaccinated and being extremely fit(run 20+ miles a week etc). It took me 3 months to shake the symptoms and I tried everything. Vitamin B IV injection(helped a little with splitting headaches I constantly had a month after covid). Vitamin D 5000iu daily, Fish Oil supplements, Zinc(had to stop from stomach issues), even tried MSM with Tumeric. I felt like alot of them did not make that much of a difference, taking NUUN(a electrolyte supplement seemed to work in fighting the fatigue and headaches). Glad there is something out there that finally works well.

Re: Metformin shown to prevent long Covid

#158

Post by stjohnswarts »

stuff4ben wrote: post #122
snemvalts wrote: post #56

Earlier quoted context omitted.

It was also tested only in overweight and obese patients. Pretty much most people are overweight and obese in the US as well, I wouldn't draw any results from this study for people at normal weight.

That is a terrible conclusion to draw. BMI is a horrible indicator of health and to say that this study has no merit to "normal" people is idiotic. Also the jab against people in the US doesn't have any place in a scientific discussion of this study. Keep your prejudices to yourself next time.

BMI is fine as an indicator of "are you fat or not", UNLESS you are a very fit athlete. However being fat and being unhealthy aren't 1 to 1, contrary to popular bias and stereotypes. I've known plenty chubby and healthy people. They might not run marathons but get on with their lives just fine. Certainly it can raise your chances of being unhealthy but it's certainly not 1:1 as many online "experts" seem to claim.

Re: Metformin shown to prevent long Covid

#159

Post by shaftway »

peteradio wrote: post #153
ceedan wrote: post #148

Earlier quoted context omitted.

Both points are not true. Participants section of the paper > We excluded people who were already taking one of the study medications or who had already received a COVID-19 treatment with Emergency Use Authorization by the US Food and Drug Administration. Baseline characteristics table, Medical history section > Only 17 (1.5%) of the participants had diabetes.

How many had pre-diabetes? Type-2 is a pretty serious diagnosis above a pretty significant threshold. Long-covid as defined can be somewhat marginal in characteristic.

Metformin also helps keep you under that threshold. Without Metformin my A1C is typically around 10 but with it I'm usually around 5. This complicates classification.

Re: Metformin shown to prevent long Covid

#160

Post by vonnik »

thenerdhead wrote: post #94
cqz wrote: post #41

Earlier quoted context omitted.

Possible but untested. You may be interested to see this recent study that draws a mechanistic link (broadly, microglial inflammation) between the symptoms of long covid and "chemobrain" following chemotherapy [0]. The authors do suggest treatments proposed to restore cognition post-chemotherapy may also be applicable to long covid, e.g. metformin [1]. [0] https://www.cell.com/cell/fulltext/S0092-8674(22)00713-9 [1]…

Metformin is looking like the aspirin of the 21st century.

Nir Barzilai and a team of researchers are leading a large clinical trial to test the benefits of metformin in slowing the aging process, which is upstream of so many diseases that yeah, it could just be a cheap cure-all. Sadly requires a prescription in the US. But berberine is the off-the-shelf equivalent.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347426/

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