Wow, Red Bull does give you wings!
Taurine deficiency as a driver of aging
291–300 of 301 posts
Re: Taurine deficiency as a driver of aging
#292Earlier quoted context omitted.
I'm with xcv here. It's impossible to have a logical discussion with someone who doesn't see a contradiction between "sucralose is toxic" and "there is nothing wrong with sucralose", and it's impossible to have a fairminded discussion with someone who gives objections as speed bumps instead of arguments. If you really cared whether he had linked to a news article vs a study, you would have been satisfied and apologet…
I'm really not understanding why this is being called a contradiction. These studies have, in a good scientific fashion, uncovered some amount of evidence. This evidence has to stand up against 25 years of the FDA recognizing sucralose as generally-recognized-as-safe (GRAS), and the decades prior that made it reach that point. That's a tall hurdle! A contradiction as the term is being used here, to claim my position…
I agree that the sentences you quoted didn't contradict anything you wrote and I was on your side at that point. After xcv explained that he meant the link, I was annoyed that he had been so vague, but I updated my expectation to "ok, now Blackthorn will understand the intended contradiction and either agree or explain why both things somehow can be true at the same time".
I think xcv is right that the problem lay in your definition of "contradiction". Whether Position A contradicts Position B has nothing to do with whether Position A has mathematical proof or the FDA agrees with Position B. It's simply whether A and B can both be true at the same time. "Toxic" and "nothing wrong with it" cannot.
Thank you for having a reasonable discussion with me though!
Re: Taurine deficiency as a driver of aging
#293I order stuff off the Internet from time to time including taurine, is there an easy/cheap way to test things that come through the post from Amazon or another company are Taurine and don’t contain things they shouldn’t? The supplement industry strikes me as dubious! Is there a better way to think about this?
Best way the average person without access to very fancy lab equipment can navigate this is to source from a company that has built their brand on testing and quality. A brand like Thorne or Jarrow has a lot of motivation to test everything and make sure nothing untoward makes it out, since that reputation is the only thing that lets them charge a premium vs the commodity brands.
Re: Taurine deficiency as a driver of aging
#294Solid study, but the core results are based on a single genotype of mouse — C57BL/6J. Imagine a clinical study of longevity using 120 clones of you or me. Taurine may be effective at extending lifespan and healthspan of C57BL/6J mice but will it work as well using genetically diverse mice such as the UM-HET3 mice? Like humans, the UM-HET3 mice are genetically diverse (they segregate for about 11.5 million sequence va…
By the way: A 16 oz can of Monster contains 2 grams of taurine. My first thought when I reading your post (before I finished): How many grams of taurine per kilogram of body weight were used in the trial? I found: Taurine supplementation increases the life span of mice To determine whether the observed drop in taurine concentration contributes to aging, we orally administered control solution or taurine at 1000 mg pe…
There were some other replies in the thread. Does not scale linearly from mouse to humans. The human equivalent (from memory) is about 8 gm/day.
Re: Taurine deficiency as a driver of aging
#295Earlier quoted context omitted.
According to GPT4 there's research indicating that taurine increases metabolism, improves athletic performance, helps regulate neurotransmitters (so could be construed to improve cognitive functioning), and improves cardiovascular health. I'd wager you can't conclude from any of that research that putting a gram of it in a drink will help with anything at all, but from a marketing perspective it's a name that carries…
according to gpt4 there's reasearch that indicates that spice melange assists in cognitive loads especially relating to navigation in fold space
Love it! Waiting eagerly for next installment of Dune.
Re: Taurine deficiency as a driver of aging
#296Earlier quoted context omitted.
WHy does it have Taurine? I honestly don't know why any of the non-caffiene non-b vitamin ingredients are in "energy drinks" like Taurine.
I really wish they didn't have so much damn niacin(B3) in them. Niacin has side effects like sweating and flushing in doses not much higher than RDI, and yet one 500ml energy drink typically contains 250% RDI of niacin. Like, why the fuck? At least cut it down to at most 100%.
No, there are different forms of vitamin B3. Niacinamide (aka nicotinamide) is the non-flushing form.
It is a reasonably well documented protectant of neurons and mitochondria.
Here is one great example publication related to a mouse model of glaucoma:
https://pubmed.ncbi.nlm.nih.gov/28209901/
I take 3 gm/ day and have for 6 years with what I think are notable improvements in cognitive function. Your mileage may vary.
Re: Taurine deficiency as a driver of aging
#297Earlier quoted context omitted.
That's because Monster has caffiene and other chemicals in there that may kill you! The Taurine itself probably won't kill you as LD50 is 5g per kg of body weight
LD50 should be taken with a huge grain of salt for any compound. First of all LD50 is just the dose required to kill half the subjects within some short time frame. Long term toxicity is not captured by this number. And doses well below LD50 can still kill you. Also, because you can't overdose humans with drugs until half of them die(in most jurisdictions...), the number is pretty much always based on animal experime…
> Crucially, a dose of 1g/kg has never been tested in humans in the short or long term.
I wonder if some bodybuilders didnt take a lot of taurine
Re: Taurine deficiency as a driver of aging
#298Earlier quoted context omitted.
That makes me wonder how much of the physiological lifecycle we can offload the external processes and how much effect would that have on a human being? We know, for instance, that connecting the circulatory system from an older animal to a younger one will cause the body of the younger animal to spend energy healing the cellular damage of the older one and can cause the older one to become younger by the markers we…
I don't think we'd be permanently attached, in that scenario. It would be more like a dock you attach to at night, or when at home. Still horrific, don't get me wrong, but much less socially gauche than hauling a backpack full of spare parts around.
So basically we would have ports installed? I'm guessing near the kidneys since there are large vessels there that could be tapped into. That's slightly more terrifying to me than carrying an organ sack, but I guess it's important to look good in speedos, too.
Re: Taurine deficiency as a driver of aging
#299Earlier quoted context omitted.
Human-mouse conversion ratio is 1:12.3, so about 6g a day. I easily eat a gram if I drink a ton of coffee.
Thank you to share! Where does that ratio come from? Please educate us.
The human-mouse equivalent dose ratio/interspecies allometric scaling is a foundational topic in exploratory pharmacological studies. You can find information f.e. in "A simple practice guide for dose conversion between animals and human".
Re: Taurine deficiency as a driver of aging
#300I order stuff off the Internet from time to time including taurine, is there an easy/cheap way to test things that come through the post from Amazon or another company are Taurine and don’t contain things they shouldn’t? The supplement industry strikes me as dubious! Is there a better way to think about this?
I’ve been considering the same. I think, first off, Amazon is absolutely the worst place to buy supplements due to potential fakes. I’ve seen consumer labs.com has done some independent 3rd party testing but it’s not on everything. There are nootropic outfits that will send you the COA on request. Obviously, who knows what that piece of paper is worth. They could have bought a clean report or could have done a bait a…
I know it sounds mad but I just want a well tested drink that contains zero stimulants and plenty of good stuff like 6g Taurine, l-cystine, some good magnesium etc. if I knew the testing/provenance of this stuff I’d probably pay $5 per can.