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Ozempic drug supresses desire to smoke, drink and more?

theatlantic.com

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Re: Ozempic drug supresses desire to smoke, drink and more?

#401

Post by jmpman »

usernew wrote: post #299
vore wrote: post #276

Earlier quoted context omitted.

This is such a "one weird trick your doctor doesn't want you to know!" anecdote. Mounjaro and Ozempic are generally prescribed in instances where dietary interventions are insufficient and perhaps one of the last resorts before bariatric surgery. If your dietary interventions worked for you -- great! But there is only a certain class of people for which they work for, and it is rude to assume the OP hasn't tried thes…

and... this person now takes these last-measure pills forever? or here in the real world, do they use the pills to lose weight, and then maintain that normal weight forever with... perhaps a diet trick that works? people who have to take last-measure medication usually don't stop eating when they are full. i know, it's weird to tell someone who doesn't stop eating when they're full, how to still maintain weight if th…

I’m hopeful that it’s more like 3 months out of the year. Looking back over the years, I’ve gained roughly 5lbs/year since I hit 30. Now in my late 40’s, during Covid, it seems like that went to 10lbs/year. The first 3 months on mounjaro, I lost 20lbs, so that cycle should be sufficient. I’d stay on it permanently, if it weren’t for the $1200/month.

Re: Ozempic drug supresses desire to smoke, drink and more?

#402

Post by jmpman »

helsinkiandrew wrote: post #284
jmpman wrote: post #151

I’ve been on Mounjaro since August. Down almost 60lbs, and it’s been a life changer. Have I had some gastrointestinal issues, sure, but expected. I feel great and my brain seems to be functioning as well as when I was in my 20’s. Now, when I go to the bar with friends, I end up having maybe 2 beers and although enjoyable, I don’t feel that light switch turning on which encourages me to drink more. Can I force myself…

> but there’s some reward center that’s no longer lighting up. Do you find other pleasures (non food and drink) as enjoyable? Interesting to hear if it’s selective or dampens everything.

Sex, sure. Video games - maybe.

Re: Ozempic drug supresses desire to smoke, drink and more?

#403

Post by jmpman »

CapstanRoller wrote: post #312
jmpman wrote: post #151

I’ve been on Mounjaro since August. Down almost 60lbs, and it’s been a life changer. Have I had some gastrointestinal issues, sure, but expected. I feel great and my brain seems to be functioning as well as when I was in my 20’s. Now, when I go to the bar with friends, I end up having maybe 2 beers and although enjoyable, I don’t feel that light switch turning on which encourages me to drink more. Can I force myself…

>I feel great and my brain seems to be functioning as well as when I was in my 20’s >but my untreated ADHD seems to be getting worse. I had very similar results after taking ketamine for treatment-resistant depression. It eliminated all my compulsive tendencies for getting cheap dopamine hits (food, doomscrolling, etc), reset my tolerance to everything (caffeine, ADHD meds, alcohol), and made my ADHD worse while impr…

> anhedonia

Possibly slightly, but not life impacting.

Re: Ozempic drug supresses desire to smoke, drink and more?

#404

Post by jmpman »

remote_phone wrote: post #216
jmpman wrote: post #151

I’ve been on Mounjaro since August. Down almost 60lbs, and it’s been a life changer. Have I had some gastrointestinal issues, sure, but expected. I feel great and my brain seems to be functioning as well as when I was in my 20’s. Now, when I go to the bar with friends, I end up having maybe 2 beers and although enjoyable, I don’t feel that light switch turning on which encourages me to drink more. Can I force myself…

I heard that 2/3 of the weight loss is muscle, do you find that to be the case?

I don’t have any quantifiable data, but although I’m certain the majority of the weigh has been fat, I’m sure I’ve lost quite a bit of muscle too.

Re: Ozempic drug supresses desire to smoke, drink and more?

#405

Post by chriscappuccio »

rjbwork wrote: post #313
LazyMans wrote: post #155

Yes. On a compounded semaglutide. I can finally control my hunger and a nice unexpected effect has been losing a desire to drink large quantities of alcohol. I don’t drink during the week anyway, but it seems to be the volume that turns me off to drinking. Thus a few cocktails are all I can tolerate. For context, Im 30, male, would be defined as a binge drinker on weekends. Oh, and I’ve given up nicotine entirely. I…

Can you share this "compounded semaglutide" source? My doctor mentioned it but I'm a bit anxious about it. Everything out there seems so sketchy.

wellsrx is a reliable source

Re: Ozempic drug supresses desire to smoke, drink and more?

#406

Post by pixl97 »

pton_xd wrote: post #302
pixl97 wrote: post #101

Earlier quoted context omitted.

Weight has been increasing for nearly 40 years now in the US among all groups. Trying to point this out as any kind of individual failure just has not, and is not going to work. It's tantamount to telling someone to stop smoking in 1950. Yes, some people did manage to, but the vast majority stopped smoking when their lungs no longer supported them living. When pretty much everywhere you go is plastered in signs sayin…

> Weight has been increasing for nearly 40 years now in the US among all groups. Although interestingly it's still far lower among Asians in the US than any other group. Why is that? [1] https://www.cdc.gov/obesity/data/adult.html

A small group that's used a different selection mechanism than the primary population is really a poor metric to judge the majority. It seems likely that we'd find that migrant populations that have to a lot of work to get where they are have a higher motivation level than the general population.

One should look at Asian obesity level growth, then compare the populations you're talking about in particular

https://www.adb.org/sites/default/files/publication/320411/a...

Some Asian countries still have rather low obesity growth compared to the world average.

Re: Ozempic drug supresses desire to smoke, drink and more?

#407

Post by chriscappuccio »

mym1990 wrote: post #64
spondylosaurus wrote: post #60

Earlier quoted context omitted.

> I am really concerned this is going to lead to a bigger health crises than the one it purported to solve. A lot of diabetics taking it to regulate blood sugar (particular the feedback loop with insulin and hunger) have said it's changed their life... but for people who are merely overweight I think the benefits may not always be worth the side effects. IMO the correlation between weight and health is not as strong…

I think weight is the wrong thing to target for gauging health, but it is the thing that is in everyone's face and easy to see. Undernourishment is just a big of a problem as over-nourishment. Targeting the four horsemen(t2 diabetes, Alzheimer's, heart disease, cancer) is a better use of time and money, but they are relatively much harder to identify early.

> Targeting the four horsemen(t2 diabetes, Alzheimer's, heart disease, cancer) is a better use of time and money, but they are relatively much harder to identify early.

All of these diseases have significant input from bad diet and metabolic disorder. Alzheimer's is considered a variation of t2d in some circles.

Re: Ozempic drug supresses desire to smoke, drink and more?

#408

Post by chriscappuccio »

reaperman wrote: post #137
crakenzak wrote: post #2

Now if only it didn’t cost so damn much every month even under insurance =(

You can get these wholesale from China from "reputable" gray-market wholesalers who get the chemicals made at contract manufacturing facilities. BYO QA/QC though, as with all non-FDA drugs. That's the huge catch, and it sucks for consumers. Testing just for active ingredient is >$100 and takes about a month. Testing for proper buffering agents, harmful contaminants, microbial contamination, etc is essentially unavail…

where is this grey market? apparently it's not as simple as just searching aliexpress :)

Re: Ozempic drug supresses desire to smoke, drink and more?

#409

Post by chriscappuccio »

tsimionescu wrote: post #354
justinbaker84 wrote: post #38

Earlier quoted context omitted.

A lot of clinics are administering the generic form and it is still very expensive.

If a drug is under a patent, the generic form still pays royalties to the patent holder, so of course it's still expensive.

not entirely true. semaglutide is a great example. the FDA allows compounding pharmacies to make semaglutide because wegovy/ozempic are sold out and therefore have limited availability. compounding pharmacies are allowed to sell their own royalty-free in this situation! wellsrx does just this (probably with chinese sourced semaglutide)

Re: Ozempic drug supresses desire to smoke, drink and more?

#410

Post by reaperman »

scheme271 wrote: post #371
reaperman wrote: post #247

Earlier quoted context omitted.

Anything specific would be inappropriate for this forum. But the broad answer is a chemicals distributor in China. I actually only utilize them for legal "nutritional" compounds, but others use them for pharmaceutical options, and those are independently tested frequently by a variety of stakeholders. Personally I really wish US citizens didn't feel forced to go outside of the quality protections of the FDA for their…

Nutritional compounds? My understanding is that without a lot of special processing, GLP-1 agonists (semiglutide, liraglutide, tirzepatide, etc) will be degraded by stomach acids into useless fragments. There's an oral semiglutide formulation but it looks like it's quite inefficient and has some pretty strigent requirements in order to be effective.

What? No one is taking these orally. Hence the bacteriostatic water for injection.

The same distributor sells legal things to import like L-Carnitine, Epitalon, Berberine, NAD+, NACET, and vitamins at great prices so I was saying I use them for things like that.

But others use them for GLP-1 agonists and many do their own independent testing.

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