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Ozempic drug supresses desire to smoke, drink and more?

theatlantic.com

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Re: Ozempic drug supresses desire to smoke, drink and more?

#221

Post by etchasketch »

ortusdux wrote: post #44
lumb63 wrote: post #23

I’m glad people are enjoying Ozempic. My experience from seeing a family member on it, is I would not touch it if I were a 500-pound alcoholic smoking two packs of cigarettes a day. That’s an exaggeration since it probably outweighs the health issues there, but only slightly. The person I know taking Ozempic has only lost weight (35 lbs) due to the fact that eating now makes her sick. She has been sapped of all energ…

>>due to the fact that eating now makes her sick. Reminds me of the first FDA approved weight loss drug, Alli, that basically just gastrointestinally punishes you if you eat more than a few grams of fat. https://en.wikipedia.org/wiki/Orlistat#Side_effects

You want to know what's even crazier, you can literally but it over the counter. I was at kroger the other day and I saw it next to the vitamins and I did a double take.

Re: Ozempic drug supresses desire to smoke, drink and more?

#222

Post by etchasketch »

reaperman wrote: post #137
crakenzak wrote: post #2

Now if only it didn’t cost so damn much every month even under insurance =(

You can get these wholesale from China from "reputable" gray-market wholesalers who get the chemicals made at contract manufacturing facilities. BYO QA/QC though, as with all non-FDA drugs. That's the huge catch, and it sucks for consumers. Testing just for active ingredient is >$100 and takes about a month. Testing for proper buffering agents, harmful contaminants, microbial contamination, etc is essentially unavail…

Interesting.

Re: Ozempic drug supresses desire to smoke, drink and more?

#223

Post by Auracle »

Jun8 wrote: post #178

So, instead is suppressing the desire to eat, how about inventing a drug that blocks the absorption or breakdown of carbohydrates in the gut? Or maybe control the gut biome so that growth of bacteria that breaks down high calorie food is minimized. Is this faster-than-light-like impossible daydream or is there any plausible path to it?

I don’t know if I want a drug to exist that allows people to be gluttons without consequence. It’s like a modern (and real) vomitorium.

Re: Ozempic drug supresses desire to smoke, drink and more?

#225

Post by Red_Leaves_Flyy »

yieldcrv wrote: post #211
ramraj07 wrote: post #196

Earlier quoted context omitted.

For a long time we have known the existence of a network of hormones controlling our apetite on the gut brain axis, with names like ghrelin, leptin, glp-1, orexin, somatostatin, list goes on [1]. Issue was the network was tres complicé and hard to perturb without getting the opposite effect than what we wanted. Finally with glp-1, sglt2 and pcsk9 inhibition we are starting to be able to correct in the right way. To a…

can we do this for working out and exercise? I’m lean but dont do that and can recognize the benefits. It would be cool if we could pharmacologically make that appealing too. What if we could just continually swap in states. Executive work mode, ah it feels so good to think and focus. Empath mode, ah it feels so good to build relationships. Brolic mode, ah it feels so good to think about working out, and actually wor…

Do you want to live in the world of we happy few? This is what you’re suggesting with your rose colored glasses. What would really happen is companies would get the drug legalized so they can pump into their employees.

Re: Ozempic drug supresses desire to smoke, drink and more?

#226

Post by Auracle »

shusaku wrote: post #117
furyofantares wrote: post #88

Earlier quoted context omitted.

> Sad that the obvious route (diet and exercise) is skipped by so many people Many people also try it repeatedly for several years or even decades, failing all the while. There's also psychological issues that make this hard (possibly among other issues), and no pithy remedy like "try diet and exercise" for that (well, ok, sometimes people say "try therapy" this way, but we can include people who've included that for…

I also think the problem is that if you’re losing weight, you’re by definition not eating healthy. If you could skip to the fat gone step, and work on a diet that maintains a healthy weight, it seems like you would have a easier time adjusting.

I guess we’ll see if that works out once people stop using this class of drugs. I bet most rebound.

Re: Ozempic drug supresses desire to smoke, drink and more?

#227

Post by beebmam »

tick_tock_tick wrote: post #214
ramraj07 wrote: post #196

Earlier quoted context omitted.

For a long time we have known the existence of a network of hormones controlling our apetite on the gut brain axis, with names like ghrelin, leptin, glp-1, orexin, somatostatin, list goes on [1]. Issue was the network was tres complicé and hard to perturb without getting the opposite effect than what we wanted. Finally with glp-1, sglt2 and pcsk9 inhibition we are starting to be able to correct in the right way. To a…

> yeah turns out it was never about will power. What a completely silly take away. It's like nature vs nurture it's not 100% one thing only.

Free will has not been shown to exist. Everything is nature.

Re: Ozempic drug supresses desire to smoke, drink and more?

#228

Post by Danjoe4 »

PostOnce wrote: post #203

Exercise is free and the side effects are you get stronger, more energetic, and better looking. Ozempic costs money and its side effects include cancer, kidney failure, and ruining your eyes. https://www.ozempic.com/faqs.html edit: many point out calorie intake is the real problem, it's true: buy a kitchen scale, weigh your food, count your calories, and you will lose weight. Exercise is optional compared to that. St…

Exercise is not an effective weight loss intervention. It's something you should do for your cardiovascular health, strength, and cardiovascular health.

Re: Ozempic drug supresses desire to smoke, drink and more?

#229

Post by leroy-is-here »

beebmam wrote: post #227
tick_tock_tick wrote: post #214

Earlier quoted context omitted.

> yeah turns out it was never about will power. What a completely silly take away. It's like nature vs nurture it's not 100% one thing only.

Free will has not been shown to exist. Everything is nature.

Reality does not need to be peer-reviewed to be true.

Re: Ozempic drug supresses desire to smoke, drink and more?

#230

Post by yieldcrv »

Red_Leaves_Flyy wrote: post #225
yieldcrv wrote: post #211

Earlier quoted context omitted.

can we do this for working out and exercise? I’m lean but dont do that and can recognize the benefits. It would be cool if we could pharmacologically make that appealing too. What if we could just continually swap in states. Executive work mode, ah it feels so good to think and focus. Empath mode, ah it feels so good to build relationships. Brolic mode, ah it feels so good to think about working out, and actually wor…

Do you want to live in the world of we happy few? This is what you’re suggesting with your rose colored glasses. What would really happen is companies would get the drug legalized so they can pump into their employees.

Then some people would feel there is a lopsided power dynamic in their choice to take them.

In the meantime I would like that choice from a purely self preservation interest in being good at other bodily health and resource appropriations

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