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Ozempic drug supresses desire to smoke, drink and more?

theatlantic.com

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Re: Ozempic drug supresses desire to smoke, drink and more?

#201

Post by quazar »

reaperman wrote: post #175
scheme271 wrote: post #21

Earlier quoted context omitted.

GLP-1 agonists are a bit more tricky since they are temperature sensitive and need to be injected. You'll really need to be careful to keep it sterile and handle it properly. Whether the "research chemical" will receive the proper care until it gets into your hands is something that you're literally gambling your health on.

You ship it as a dry/lypohilized powder, both semaglutide and tirzepatide survives long China->Europe shipping in the summer just fine, with customs delays. The testing I've seen showed 99.965% purity of semaglutide after 22 days in shipping from China to Poland during April. Tirzepatide shows 99.064% purity after 58 days of shipping in October-November. These didn't start out at 100.00% purity either, so they likely…

Where do you buy it from to ship to Poland?

Re: Ozempic drug supresses desire to smoke, drink and more?

#202

Post by mchannon »

reaperman wrote: post #136
rektide wrote: post #9

I'm surprised Ozempic gets all the press. Supposedly Mounjaro is all that and more. The wonderful Paul Ford has the best writeup I've seen that discusses these more meta levels, the post-human implications of a drug we can genuinely widescalely reprogram ourselves with. Paul's so great. https://www.wired.com/story/new-drug-switched-off-appetite-m... https://news.ycombinator.com/item?id=34660232

Semaglutide gets all the press because it's a lot cheaper and actually available (barely available, but available). Tirzepatide is much more difficult to get access to, though IMO it should be the one that people default to if they're going to take this class of drug. Semaglutide will probably have the most side effects because it only has one action (GLP-1 agonist). Tirzepatide has slightly lower side effects becaus…

Eli Lilly's scientific name for LY3437943 is retatrutide.

Re: Ozempic drug supresses desire to smoke, drink and more?

#203

Post by PostOnce »

Exercise is free and the side effects are you get stronger, more energetic, and better looking.

Ozempic costs money and its side effects include cancer, kidney failure, and ruining your eyes.

https://www.ozempic.com/faqs.html

edit: many point out calorie intake is the real problem, it's true: buy a kitchen scale, weigh your food, count your calories, and you will lose weight. Exercise is optional compared to that. Still, both are free and have more benefits.

Re: Ozempic drug supresses desire to smoke, drink and more?

#204

Post by ouid »

Atsuii wrote: post #198
lotsofpulp wrote: post #193

Earlier quoted context omitted.

Given a significant percent of voters are overweight and obese, it would be very politically popular to legislate that health insurance must pay for GLP-1 antagonists.

Wouldn't this cause insurers to have to raise their premiums for everyone substantially?

No. The additional costs to the healthcare system due to people being overweight probably exceed 12000/person/year, but if not exceed it, they certainly come close. Moreover, it's not unheard of to mandate cheaper drug prices, and now that we understand how these drugs work, there will be more of them in the pipeline.

Re: Ozempic drug supresses desire to smoke, drink and more?

#205

Post by caymanjim »

PostOnce wrote: post #203

Exercise is free and the side effects are you get stronger, more energetic, and better looking. Ozempic costs money and its side effects include cancer, kidney failure, and ruining your eyes. https://www.ozempic.com/faqs.html edit: many point out calorie intake is the real problem, it's true: buy a kitchen scale, weigh your food, count your calories, and you will lose weight. Exercise is optional compared to that. St…

Exercise does nothing for weight loss if you're eating too much. Exercise has health benefits, but weight loss is not one of them for the vast majority of people. People wildly overestimate how many calories they're burning.

Re: Ozempic drug supresses desire to smoke, drink and more?

#206

Post by justinclift »

SystemOut wrote: post #183
lumb63 wrote: post #23

I’m glad people are enjoying Ozempic. My experience from seeing a family member on it, is I would not touch it if I were a 500-pound alcoholic smoking two packs of cigarettes a day. That’s an exaggeration since it probably outweighs the health issues there, but only slightly. The person I know taking Ozempic has only lost weight (35 lbs) due to the fact that eating now makes her sick. She has been sapped of all energ…

My story / anecdata. About 6 months ago there was a posting about Ozempic and I had said something to the effect that it wasn't worth it watching some of the side effects my wife had from it. And then I went to the doctor for a check-up and lo and behold I had diabetes. Asymptomatic, but an A1C of 11. My doctor re-ran the test because he didn't believe it and it doesn't run in my family. My cholesterol had also jumpe…

Out of curiosity, do you drink much water each day?

I'm kind of wondering if the people having a bad result don't drink enough water each day to clear out their systems? Yeah, that's a simplistic take... but still, curiosity. :)

Re: Ozempic drug supresses desire to smoke, drink and more?

#207

Post by chaostheory »

PostOnce wrote: post #203

Exercise is free and the side effects are you get stronger, more energetic, and better looking. Ozempic costs money and its side effects include cancer, kidney failure, and ruining your eyes. https://www.ozempic.com/faqs.html edit: many point out calorie intake is the real problem, it's true: buy a kitchen scale, weigh your food, count your calories, and you will lose weight. Exercise is optional compared to that. St…

It’s just like intermittent fasting. Nearly everyone can afford it, but only a few people are willing to pay.

While aerobic exercise is more for a healthy circulatory system, anaerobic exercise has proven effective in weight loss.

Re: Ozempic drug supresses desire to smoke, drink and more?

#208

Post by nwienert »

PostOnce wrote: post #203

Exercise is free and the side effects are you get stronger, more energetic, and better looking. Ozempic costs money and its side effects include cancer, kidney failure, and ruining your eyes. https://www.ozempic.com/faqs.html edit: many point out calorie intake is the real problem, it's true: buy a kitchen scale, weigh your food, count your calories, and you will lose weight. Exercise is optional compared to that. St…

Exercise has many side effects too, including a risk of injury.

Meanwhile GLP-1 protects and even improves the function of brain, lungs, heart, muscles, bones, and kidneys, it improves sleep quality and reduces sleep duration, it definitely decreases addictive behavior, and even seems to help with some immune issues (anecdotally, but the effect is so strong it’s remarkable).

https://en.m.wikipedia.org/wiki/Glucagon-like_peptide-1#/med...

Re: Ozempic drug supresses desire to smoke, drink and more?

#209

Post by justinclift »

User23 wrote: post #104
ortusdux wrote: post #44

Earlier quoted context omitted.

>>due to the fact that eating now makes her sick. Reminds me of the first FDA approved weight loss drug, Alli, that basically just gastrointestinally punishes you if you eat more than a few grams of fat. https://en.wikipedia.org/wiki/Orlistat#Side_effects

My favorite fat loss drug along these lines is dinitrophenol. It is the true miracle fat burning drug. It interferes with cellular metabolism in such a way that the body just nonstop oxidizes fat. Fat mass loss in the order of a pound a day or more is entirely possible and some bodybuilders use it to get to a ludicrously low bodyfat percentage. Unfortunately oxidizing that much fat generates a lot of heat, so much th…

Is this the one? :)

https://en.wikipedia.org/wiki/2,4-Dinitrophenol#Toxicity

Re: Ozempic drug supresses desire to smoke, drink and more?

#210

Post by nwienert »

reaperman wrote: post #130
mym1990 wrote: post #84

Earlier quoted context omitted.

I don’t necessarily mean dangerous in the health aspect, although long term affects of these drugs are not know yet…I mean the dependency on needed the drug to keep a certain lifestyle, and then having an “oh shit” moment when you’re in a place that you can’t access it, whether that be traveling or the supply of it becomes scarce, or it gets banned, etc

That sounds like the lesser of two evils to me. Get healthier now and maybe sometime later lose access to the thing that helps you be healthier...or don't get healthier now? Yeah, there are other, orthogonal, choices but I don't think they're part of this particular decision matrix.

Yep. I lost 30lbs on it in 3 months. It took me 10 years to gain that weight.

So I guess if it takes me 10 more years to gain it back I can look into taking it again.

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