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Ozempic drug supresses desire to smoke, drink and more?

theatlantic.com

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Re: Ozempic drug supresses desire to smoke, drink and more?

#191

Post by xenospn »

User23 wrote: post #104
ortusdux wrote: post #44

Earlier quoted context omitted.

>>due to the fact that eating now makes her sick. Reminds me of the first FDA approved weight loss drug, Alli, that basically just gastrointestinally punishes you if you eat more than a few grams of fat. https://en.wikipedia.org/wiki/Orlistat#Side_effects

My favorite fat loss drug along these lines is dinitrophenol. It is the true miracle fat burning drug. It interferes with cellular metabolism in such a way that the body just nonstop oxidizes fat. Fat mass loss in the order of a pound a day or more is entirely possible and some bodybuilders use it to get to a ludicrously low bodyfat percentage. Unfortunately oxidizing that much fat generates a lot of heat, so much th…

Permanent blindness?! Ffs

Re: Ozempic drug supresses desire to smoke, drink and more?

#192

Post by paulpauper »

iwanttocomment wrote: post #74
shagymoe wrote: post #66

Earlier quoted context omitted.

Have we though? I seriously doubt doctors are aggressively pushing eating well and exercising. Has anyone ever received a workout plan from their doctor besides some generic PT exercises? Do they develop nutrition plans tailored to you? Do they track your progress? Do they have any incentive for you to actually get better? Do they require regular blood tests and include all the tests that might actually tell them som…

I seriously doubt doctors are aggressively pushing eating well and exercising. Have you ever... been to a doctor when you've been obese? I assure you that they will indeed push eating well and exercising to obese people. Even when you've already been eating well and exercising. This will not be an intervention by the PCP themselves - your primary can really just refer people to substantial interventions - but they wi…

If you are not clinically obese, and that's great, no, your PCP will not provide that type of advice. They're not there to help you with subclinical concerns with weight. There are plenty of dietitians out there who can.

yeah. If you are losing weight unintentionally, docs will care a lot and will run tests. Otherwise, being overweight, not so much. Weight loss is a bigger concern than weight gain from the perspective of doctors.

Re: Ozempic drug supresses desire to smoke, drink and more?

#193

Post by lotsofpulp »

0zemp2c wrote: post #177
iwanttocomment wrote: post #72

Earlier quoted context omitted.

Is it really a dangerous dependency ? There's been no evidence of anything happening once individuals go off of semaglutide or tirzepatide other than the tendency of gaining weight to the original levels and/or blood sugar readings returning to the pre-medication levels. This is the most common outcome anyone has trying literally any calorie-reducing diet, medication or not. There's no evidence that people are ending…

How dangerous is it to have a new $1k/month bill you need to pay forever? So far there is no indication insurance companies are going to pay for 100 million Americans going on Ozempic who aren't diabetic... Anecdotally, another danger is people confusing less eating with a healthy diet. I know someone on Ozempic...eats less but what is eaten is the same old junk...

Given a significant percent of voters are overweight and obese, it would be very politically popular to legislate that health insurance must pay for GLP-1 antagonists.

Re: Ozempic drug supresses desire to smoke, drink and more?

#194

Post by randallsquared »

NickC25 wrote: post #30

[flagged]

> Sad that the obvious route (diet and exercise) is skipped by so many people

It is definitely true that many people find it difficult to be abjectly miserable all the time. The difference with Ozempic/Wegovy is (and I know this is hard to believe!) you can eat a small portion of something and actually feel satisfied and literally just not want more. This is mind-blowing when you've never experienced it before. I've only been on the lowest dose for a few weeks, and I'm still in shock about how effortless it is to just... stop. I actually can get satisfied with food, rather than feeling too full to eat more! I have been wondering if this is just what naturally thin people feel like all the time?

Re: Ozempic drug supresses desire to smoke, drink and more?

#195

Post by reaperman »

User23 wrote: post #104
ortusdux wrote: post #44

Earlier quoted context omitted.

>>due to the fact that eating now makes her sick. Reminds me of the first FDA approved weight loss drug, Alli, that basically just gastrointestinally punishes you if you eat more than a few grams of fat. https://en.wikipedia.org/wiki/Orlistat#Side_effects

My favorite fat loss drug along these lines is dinitrophenol. It is the true miracle fat burning drug. It interferes with cellular metabolism in such a way that the body just nonstop oxidizes fat. Fat mass loss in the order of a pound a day or more is entirely possible and some bodybuilders use it to get to a ludicrously low bodyfat percentage. Unfortunately oxidizing that much fat generates a lot of heat, so much th…

Honestly GLP-1 agonists will save lives just by being the go-to replacement for people who previously would have used DNP. GLP-1 agonists are effective enough that everyone in those circles basically stopped using DNP suddenly a couple years ago.

Re: Ozempic drug supresses desire to smoke, drink and more?

#196

Post by ramraj07 »

yieldcrv wrote: post #170
jmpman wrote: post #151

I’ve been on Mounjaro since August. Down almost 60lbs, and it’s been a life changer. Have I had some gastrointestinal issues, sure, but expected. I feel great and my brain seems to be functioning as well as when I was in my 20’s. Now, when I go to the bar with friends, I end up having maybe 2 beers and although enjoyable, I don’t feel that light switch turning on which encourages me to drink more. Can I force myself…

the most surprising thing to me is how you’re describing normal behavior that I can relate to all my life, but the community of strugglers is so big that this is a whole testimonial people feel comfortable and exalted to share like thats not something I’m deriding its just news to me makes me wonder what this drug actually does, flush gut bacteria? just the right ones?

For a long time we have known the existence of a network of hormones controlling our apetite on the gut brain axis, with names like ghrelin, leptin, glp-1, orexin, somatostatin, list goes on [1]. Issue was the network was tres complicé and hard to perturb without getting the opposite effect than what we wanted. Finally with glp-1, sglt2 and pcsk9 inhibition we are starting to be able to correct in the right way.

To answer your question, yeah turns out it was never about will power. Some people just had hormone drive to be healthier than others and finally we can pharmacologically start to level the field.

1. https://www.cell.com/cell/pdf/S0092-8674(14)01503-7.pdf

Re: Ozempic drug supresses desire to smoke, drink and more?

#197

Post by coke12 »

Jun8 wrote: post #178

So, instead is suppressing the desire to eat, how about inventing a drug that blocks the absorption or breakdown of carbohydrates in the gut? Or maybe control the gut biome so that growth of bacteria that breaks down high calorie food is minimized. Is this faster-than-light-like impossible daydream or is there any plausible path to it?

Consider Alli, the drug that blocks fat absorption in the body. It already exists and works reasonably well for weight loss. The side effects can be gross and unpleasant though.

Re: Ozempic drug supresses desire to smoke, drink and more?

#198

Post by Atsuii »

lotsofpulp wrote: post #193
0zemp2c wrote: post #177

Earlier quoted context omitted.

How dangerous is it to have a new $1k/month bill you need to pay forever? So far there is no indication insurance companies are going to pay for 100 million Americans going on Ozempic who aren't diabetic... Anecdotally, another danger is people confusing less eating with a healthy diet. I know someone on Ozempic...eats less but what is eaten is the same old junk...

Given a significant percent of voters are overweight and obese, it would be very politically popular to legislate that health insurance must pay for GLP-1 antagonists.

Wouldn't this cause insurers to have to raise their premiums for everyone substantially?

Re: Ozempic drug supresses desire to smoke, drink and more?

#200

Post by fosk »

wcfields wrote: post #154
akiselev wrote: post #121

Earlier quoted context omitted.

> The only intervention that does reliably work is bariatric surgery. My understanding is surgery only works reliably because failure to comply with life style changes post-op is easily fatal and ethical doctors only perform the operation after patients have demonstrated that ability. In all but the most extreme patients, about a fifth to a third of the target weight loss has to happen pre-op for doctors to even cons…

New addictions post bariatric surgery is fairly common. Gambling for instance [1] replaces food. [1] https://www.researchgate.net/publication/332884264_Gambling_...

Clinically, what causes the urge to have an addiction? Like in your statement, replacing food with gambling. I would assume that these are fundamentally two different reward systems for the brain, or maybe not?
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