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Heavy marijuana use increases schizophrenia in men, study finds

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Re: Heavy marijuana use increases schizophrenia in men, study finds

#81

Post by int_19h »

sosodev wrote: post #38
yieldcrv wrote: post #27

Earlier quoted context omitted.

15mg THC is 3x as much as I’d suggest to someone that doesn't use edibles no matter how familiar they are with smoking

Agreed, it's surprising to me that I've met many people who claim that edibles are terrible/terrifying. They often don't know how much they took and if they do it's usually way too much for the first time. I suspect it's a combination of bad design (a single gummy being >=10mg) and the fact that most people just don't read and comprehend the labels.

Many people's experience with edibles - especially if it was before legalization - is from homemade stuff, where both the amounts and their distribution throughout the food can be very imprecise.

Re: Heavy marijuana use increases schizophrenia in men, study finds

#82

Post by mrguyorama »

saulpw wrote: post #67
rdruxn wrote: post #17

Earlier quoted context omitted.

I would counter that by pointing out that if your aim is to achieve a certain degree of bioavailability of TCH, you'd have to smoke a larger quantity of a lower-potency product, thus exposing yourself to more of the combustion by-products than necessary.

With high-potency strains you can't titrate effectively. "One puff" is a highly variable amount and you can't take 1.3 puffs. Not to mention that there's a minimum amount you have to put in a bowl, and if you don't smoke it, it gets stale and unpleasant. It's like having 85% ABV wine and pouring it into a wine glass and then what? Just take 1.3 sips and pour it back into the bottle?

Pack a smaller bowl. This really isn't difficult. You can VERY easily modulate how much plant matter you put into the bowl and even with very high test strains, you can easily take a smaller puff and wait longer between lighting up. This isn't hard.

Re: Heavy marijuana use increases schizophrenia in men, study finds

#83

Post by bitcoin_anon »

tehjoker wrote: post #39
whalesalad wrote: post #34

Earlier quoted context omitted.

I like the idea of not capping anything. Live and let live.

This will likely lead to a competitive race of stronger and stronger potency. Market dynamics aren't neutral.

Kind of like how Everclear dominates the alcohol industry?

Re: Heavy marijuana use increases schizophrenia in men, study finds

#84

Post by amanaplanacanal »

dang wrote: post #74
amanaplanacanal wrote: post #4

Study is probably crap. An association between cannabis use and schizophrenia says nothing about which way the arrow of causation flows. It could very well be that cannabis use causes schizophrenia, or it could be that people feeling early signs of schizophrenia are more likely to use cannabis. There is no way to tell from this kind of study. Science is hard.

" Please don't post shallow dismissals, especially of other people's work. A good critical comment teaches us something. " " Avoid generic tangents. " https://news.ycombinator.com/newsguidelines.html

Sorry for my cranky comment.

Re: Heavy marijuana use increases schizophrenia in men, study finds

#86

Post by wowlookatme »

kitanata wrote: post #80

You have these cells in your brain called Microglia. They are responsible for cleaning up neurons and plaques and other weird proteins. These Microglia are activated by the firing neurons which release 2-AG and AEA (Anadamide). AEA binds to the CB1 receptor in these Microglia. 2-AG binds to CB2. THC binds to CB1. CBD binds to CB2. Autistic adults have significantly low blood serum levels of AEA. Autistic people’s neu…

As somebody with autism and a history of cannabis abuse I'm curious to read more about this. Any pointers on where I could start?

Re: Heavy marijuana use increases schizophrenia in men, study finds

#87

Post by wahern »

whats_a_quasar wrote: post #41

There's a really interesting line of research that suggests Schizophrenia is a spectrum, rather than a binary. Lots of people have personality traits that are similar to schizophrenics or have genetic risk factors for the condition. Some of those people develop the full disorder, and some don't. There's evidence that the reason for the split is that psychosis is itself damaging. Once someone has a psychotic episode,…

> There's a really interesting line of research that suggests Schizophrenia is a spectrum, rather than a binary.

I don't think it was ever considered binary. Rather, previously the variance was explained in terms of discrete subtypes and comorbidities. I guess now the field is moving toward a model that is more fluid and away from a rigid ontology, at least to the extent the ontology deigned to reflect distinct pathogeneses.

I'm tempted to believe that there's an improved appreciation that progression isn't inevitable, and can be halted with management. But whatever assumptions the literature made on that score (and I'm not familiar with the literature), I'd bet most patient clinicians have always appreciated this. Understanding the why's and how's was always and still remains the problem.

Re: Heavy marijuana use increases schizophrenia in men, study finds

#88

Post by xupybd »

My father was a mental health social worker. He worked with youths, mainly teens. In his experience the vast majority of teens that ended up in his hospital had some drug fueled episode that led to their mental health crisis.

He told me that he didn't think the drugs caused the mental illness but we're often the trigger. That is these kids already had a mental illness that had not started to present symptoms until it was triggered.

My father was not opposed to drug use. He had a history of recreational drug use and many of his life long friends are heavy marijuana users. So I don't think this observation came from an anti drug bias.

Re: Heavy marijuana use increases schizophrenia in men, study finds

#89

Post by kitanata »

wowlookatme wrote: post #86
kitanata wrote: post #80

You have these cells in your brain called Microglia. They are responsible for cleaning up neurons and plaques and other weird proteins. These Microglia are activated by the firing neurons which release 2-AG and AEA (Anadamide). AEA binds to the CB1 receptor in these Microglia. 2-AG binds to CB2. THC binds to CB1. CBD binds to CB2. Autistic adults have significantly low blood serum levels of AEA. Autistic people’s neu…

As somebody with autism and a history of cannabis abuse I'm curious to read more about this. Any pointers on where I could start?

https://pubmed.ncbi.nlm.nih.gov/34744824/

This is a review not a study. It is designed to give you a broad view of current areas of active research. It does not validate any of the research it discusses. It just says “this is what is out there”.

Welcome to the rabbit hole.

Re: Heavy marijuana use increases schizophrenia in men, study finds

#90

Post by burnished »

bitcoin_anon wrote: post #83
tehjoker wrote: post #39

Earlier quoted context omitted.

This will likely lead to a competitive race of stronger and stronger potency. Market dynamics aren't neutral.

Kind of like how Everclear dominates the alcohol industry?

That analogy doesn't quite fit because as alcohol increases in purity it reaches a point where it starts to damage tissues it comes into contact with.

A better example would be 4loko when it introduced caffeine, which is contrary to the point you were trying to make.

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