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Low and moderate alcohol consumption not associated with increased mortality

jamanetwork.com

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Re: Low and moderate alcohol consumption not associated with increased mortality

#91

Post by garyrob »

mil22 wrote: post #86
garyrob wrote: post #71

Earlier quoted context omitted.

There is reason to think red wine, with its unique combination of resveratrol, phenolic acids, and flavonoids, might be an exception to that. For example, the conclusion of a meta-analysis of 12 studies on the subject says: "This study may show a protective effect of wine consumption against cognitive decline. However, it would be important for future research to differentiate the types of wine within consumption." T…

Yes, this is interesting research. If I was going to drink again, it would be limited to red wine and beer (which contains other beneficial compounds). Personally I just take pterostilbene, which is structurally similar to resveratrol and has similar health benefits but is much more bioavailable. Cognitive decline and dementia are multifactorial, and with alcohol consumption there are trade-offs between neuronal deat…

Thanks for the mention of pterostilbene which I hadn't heard of before. Will check it out. And for the brain iron article.

Re: Low and moderate alcohol consumption not associated with increased mortality

#92

Post by billyt555 »

avodonosov wrote: post #21

But low and moderate alcohol consumption is associated with high alcohol consumption (some people become alcoholics after they start drik in low amounts).

Sam Harris thinks this is true for religion as well... https://www.youtube.com/watch?v=_WOAAKMA6Hk

Re: Low and moderate alcohol consumption not associated with increased mortality

#93

Post by epistasis »

eloff wrote: post #44
epistasis wrote: post #31

Earlier quoted context omitted.

That's a very good question that we likely can't answer right now. "Woman" and "man" encompass a very wide range of bodies, with different averages, but whose distribution overlaps immensely on nearly every metric. These gender categories are standins for some subset of differences that are actually causal, but we don't have the measurements and experiments settings to pull out what is actually causal from this.

We have a clear understanding of why the difference matters here, see my other comment in this thread.

But in order to "know" that we need to do the proper causal analysis that shows that weight and alcohol dehydrogenase expression levels completely explain the differences.

Re: Low and moderate alcohol consumption not associated with increased mortality

#94

Post by garyrob »

mil22 wrote: post #86
garyrob wrote: post #71

Earlier quoted context omitted.

There is reason to think red wine, with its unique combination of resveratrol, phenolic acids, and flavonoids, might be an exception to that. For example, the conclusion of a meta-analysis of 12 studies on the subject says: "This study may show a protective effect of wine consumption against cognitive decline. However, it would be important for future research to differentiate the types of wine within consumption." T…

Yes, this is interesting research. If I was going to drink again, it would be limited to red wine and beer (which contains other beneficial compounds). Personally I just take pterostilbene, which is structurally similar to resveratrol and has similar health benefits but is much more bioavailable. Cognitive decline and dementia are multifactorial, and with alcohol consumption there are trade-offs between neuronal deat…

May I suggest that, if you have't already, you get a 23andme. "While light alcohol consumption has been associated with a decreased risk of AD in general [127], this relationship does not appear to hold in ApoE4 carriers. Consumption of any amount of alcohol may increase the risk of AD[Alzheimer's disease] for ApoE4 carriers [128,129,130]. In one study, both light and moderate alcohol consumption were associated with improvement in learning and memory for non-carriers, but with a decline in learning and memory for carriers [129]. Other studies found that ApoE4 carriers who consumed alcohol one or more times per month had a higher risk of AD than those who never consumed alcohol [128] and the risk of AD for carriers increased with increasing amounts of alcohol consumption [130] These data suggest that alcohol consumption should be limited, especially in ApoE4 carriers." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8073598/

Re: Low and moderate alcohol consumption not associated with increased mortality

#95

Post by garyrob »

mil22 wrote: post #86
garyrob wrote: post #71

Earlier quoted context omitted.

There is reason to think red wine, with its unique combination of resveratrol, phenolic acids, and flavonoids, might be an exception to that. For example, the conclusion of a meta-analysis of 12 studies on the subject says: "This study may show a protective effect of wine consumption against cognitive decline. However, it would be important for future research to differentiate the types of wine within consumption." T…

Yes, this is interesting research. If I was going to drink again, it would be limited to red wine and beer (which contains other beneficial compounds). Personally I just take pterostilbene, which is structurally similar to resveratrol and has similar health benefits but is much more bioavailable. Cognitive decline and dementia are multifactorial, and with alcohol consumption there are trade-offs between neuronal deat…

"While light alcohol consumption has been associated with a decreased risk of AD in general [127], this relationship does not appear to hold in ApoE4 carriers. Consumption of any amount of alcohol may increase the risk of AD for ApoE4 carriers [128,129,130]." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8073598/

Re: Low and moderate alcohol consumption not associated with increased mortality

#97

Post by dzader »

mil22 wrote: post #81
dzader wrote: post #70

Earlier quoted context omitted.

Hasn't it been proven recently that they do in fact grow back? Although a quick google seems to have a conflicting info.. so /shrug

I am not aware of any such studies but I would be curious if you have references. There are only a few isolated parts of the brain that show neurogenesis (the birth of new neurons) in adulthood - the hippocampus and the olfactory bulb are the primary two examples. Alcohol kills neurons across the entire brain, with volume reductions and microstructure damage in the white and grey matter, and the damage is not limited…

Nah I don't have any studies just something I had heard but upon some investigation didn't find much in the ways of studies, so probably me just being wrong. thanks for the info!

Re: Low and moderate alcohol consumption not associated with increased mortality

#98

Post by LanceH »

tablarasa wrote: post #84
giraffe_lady wrote: post #68

Earlier quoted context omitted.

You can't be serious lol. We have a word for moon doesn't mean I eat the rocks. Islam is practiced in dozens of countries speaking hundreds of languages. Anyway I'm not asserting that no muslim has ever had alcohol or that there's no disagreement within islam about its use. But the idea that the majority of muslims are routinely violating one of the main proscriptions of their religion is an astounding claim you must…

Ha yeah this is all pointless speculation... I can't help but point out though that in my observations of religious people, it's not hard to believe that a majority or even a large majority might (temporarily, occasionally, whatever) eschew some of the central tenets of their "belief" system. Kind of like how lots of citizens can (temporarily, occasionally, whatever) eschew some of the laws. I'd hardly consider Ameri…

Doing a bit more research, according to the high school handbook, students don't run in the halls, nor do they chew gum in class.

I got the "Why do they have a word for beer?" from a Palestinian instructor I had, who was well versed in wining and dining. He was fairly cynical about the claims of "no alcohol".

Re: Low and moderate alcohol consumption not associated with increased mortality

#99

Post by slashdev »

misiti3780 wrote: post #76
eloff wrote: post #47

Earlier quoted context omitted.

Would it be better to stock your head in the sand? I’m honestly baffled by your comment.

What does alcohol consumption have to do with technology? Most people here are looking to read about tech, not yet another subjective study about the effects of alcohol.

Ah you mean why is it on HN, not why was the study performed. That's fair.

HN is wider than just technical things of course, and often includes major breaking news as well as some things of general interest. Given how common alcohol consumption is, that's probably how it ends up on the front page.

Re: Low and moderate alcohol consumption not associated with increased mortality

#100

Post by avodonosov »

billyt555 wrote: post #92
avodonosov wrote: post #21

But low and moderate alcohol consumption is associated with high alcohol consumption (some people become alcoholics after they start drik in low amounts).

Sam Harris thinks this is true for religion as well... https://www.youtube.com/watch?v=_WOAAKMA6Hk

Religion leads to alcoholism?
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