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New insights into why aspirin works so well

eurekalert.org

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Re: New insights into why aspirin works so well

#251

Post by tim333 »

IE6 wrote: post #207
thenerdhead wrote: post #171

Aspirin has been a life changer for long Covid. The other painkillers make symptoms 10x worse. Many people wonder if aspirin anti platelet/blood thinning capabilities is helping breakup microclots which brings relief. There’s also a thing called nattokinase that apparently has similar properties to aspirin and is being studied for heart disease. It has been shown to break down blood clots and even degrade the spike p…

Do you have any good literature on Aspirin and LC? Not a doubter, actually I have LC myself.

While not Aspirin alone Etheresia Pretorius has been pioneering research on microclots in LC. In a recent preprint they used Aspirin and a bunch of other stuff:

>The anticoagulant regime included dual antiplatelet therapy (DAPT- Clopidogrel 75mg + Aspirin 75mg) once a day, and a direct oral anticoagulant (DOAC- Apixaban) 5mg twice a day. A proton pump inhibitor (PPI) pantoprazole 40 mg/day was also prescribed for gastric protection.

Results:

>..Following completion of treatment, each of the different symptoms resolved in the majority of patients.

https://www.researchsquare.com/article/rs-2697680/v1

Re: New insights into why aspirin works so well

#252

Post by exq »

INTPenis wrote: post #124

When you say in 2023 that they have "new insights" as to why a common over the counter drug works it really doesn't instill great confidence in pharma. Seems like we're still grinding up rhino horns and tiger penis and hoping for the best outcome, just that we do it with extensive testing now so we get a statistically acceptable outcome viable for marketing.

“Doctors are men who prescribe medicines of which they know little, to cure diseases of which they know less, in human beings of whom they know nothing.” – Voltaire

Re: New insights into why aspirin works so well

#253

Post by waboremo »

mistrial9 wrote: post #227
fundatus wrote: post #222

Earlier quoted context omitted.

> except thousands of common herbal remedies are replaced by patent medicine with legal controls, because $MONEY Except they are not being replaced? Just like in the good old days™ you can still get out and collect the herbs you're looking for. It's just that nowadays we know that component X of a herbal remedy actually does the job so you just buy that in tablet form (or whatever) instead eating of the whole thing.

> get out and collect the herbs you're looking for. on the small chance that you are not being sarcastic.. Our city here has >300,000 residents.. and most cities nearby are paved. Where do the herbs come from ?

The same place herbs have always come from. If you don't want to step outside of your city or visit the local farms/greenhouses, then import. You can also import seeds, but it's up to you to ensure the seeds are the right ones and they have the proper environment they need to grow, and then the right tools to actually process those herbs in the "traditional" ways (or in your own experimental ways I suppose).

Herbs aren't magic you know, you've come across many if you've walked through any trail. Although I wouldn't blindly go picking anything and everything you see, some are toxic!

Re: New insights into why aspirin works so well

#254

Post by spinningD20 »

ShadowBanThis01 wrote: post #49

"it can cause detrimental side effects such as internal bleeding and organ damage" NSAIDs are also ototoxic, meaning that they cause hearing damage.

You just sent me on a research adventure. I have struggled with chronic neck tension and pain for the last 15 years with no obvious origin event, and sometimes take 2-3 ibuprofen every day to take the edge off, when it's at its worst.

Thank you for bringing this up!

Background for me for those interested:

Within a few years of struggling with chronic pain and tension headache episodes (vomiting, catch-my-breath level of pain for hours), I had my first "vertigo event". I was sitting in a chair in an office in front of a whiteboard, writing and thinking and chatting with a team, nothing special or different. Never had an inner ear issue before this moment.

Since then, I have struggled (seemingly randomly) where I have ear fullness (almost entirely without hearing on left ear for a month about 6 months ago, then everything slowly came back, for example), varied tinnitus levels, light-headedness, unable to turn around too fast without losing balance... and it waxes and wanes.

Now I am wondering if any of the waxing or waning of these symptoms have anything to do with my usage of ibuprofen. I found a study suggesting this back from 2010 just now, and wonder how I've never connected these two dots.

Of course, I have to mention neck tension and inner ear related issue, aren't the only health issue I've had in the last 15 years. I've gained GERD (probably not surprising), hashimoto's and vitiligo, as well as sudden onset of mild astigmatisms after the first few years.

I have tried my best to avoid using ibuprofen at all, but it is the only thing that can take the edge off of the neck trouble before it turns into that awful, torturous headache/barf session.

PS) I know most folks will see "neck tension" + "inner ear problems" and jump to pinched nerve, spinal damage, ergonomics, posture, etc, but even after a great deal of lifestyle changes, reduced time at an office desk, yoga, Feldenkrais method, numerous physical therapy stints, I am confident that it is not the cause and "how good I am doing posture/movement" has no strong correlation to pain levels or inner ear trouble on any given day - it is seemingly random.

PPS) Definitely open to suggestions or ideas, but I will be surprised if something is mentioned that I have not tried or looked into.

Re: New insights into why aspirin works so well

#255

Post by Kirby64 »

School-Cotton wrote: post #61
jeffparsons wrote: post #38

Earlier quoted context omitted.

It's shocking to me how we still refer to paracetamol and ibuprofen in the same breath when their relative risks are so different.

Are they? Maybe acetaminophen (i.e. paracetamol) is many times more dangerous than ibuprofen, but still, in absolute terms it must be low if used according to guidelines. I mean, most people don’t know anyone who has died or been injured from acetaminophen, so from most normal people’s everyday perspective it simply does the same thing as ibuprofen, regardless of whether that’s scientifically correct. Thus it’s easy…

The issue (in my view) is that the dose of efficacy to the dose of issue (when it starts causing problems) is MUCH closer for acetaminophen.

Acetaminophen 'usage' dose is usually 500-1000mg (1-2 pills). The dosage where it becomes significantly toxic is ~7500-10000mg (7.5-10g), which is somewhere in the range of 10x the dose.

Ibuprofen on the other hand, 'usage' dose is 200-400mg (1-2 pills, again). Toxic dosage is closer to ~16000-25000mg (16-25g), which is more like 50x the usable dose.

Since people invariably take more than the recommended dose when they're really in pain, I'd prefer the NSAID that is less toxic at higher doses... since it's not like they post toxic doses on the side of bottles.

Re: New insights into why aspirin works so well

#256

Post by m3047 »

orev wrote: post #237
1MachineElf wrote: post #236

Today an allergist told me the random lip swelling I experience (angioterma) has been caused in many other patients by NSAIDs like Aspirin, Tylenol (acetaminophen), and a Alleve (naproxen sodium). I hate to think that's true, but apparently it is a studied phenomena: https://aacijournal.biomedcentral.com/articles/10.1186/1710-...

> Tylenol (acetaminophen) Is not an NSAID. One of its primary uses is as a medication for people who can’t use NSAIDs.

NSAID: Non Steroidal Anti Inflammatory Drug

Tylenol:

* Non steroidal? Check.

* Anti inflammatory? Hrmmm... not so much.

So what are you taking it for again?

https://en.wikipedia.org/wiki/Nonsteroidal_anti-inflammatory...

It's still a COX-2 inhibitor.

Re: New insights into why aspirin works so well

#257

Post by ShadowBanThis01 »

spinningD20 wrote: post #254
ShadowBanThis01 wrote: post #49

"it can cause detrimental side effects such as internal bleeding and organ damage" NSAIDs are also ototoxic, meaning that they cause hearing damage.

You just sent me on a research adventure. I have struggled with chronic neck tension and pain for the last 15 years with no obvious origin event, and sometimes take 2-3 ibuprofen every day to take the edge off, when it's at its worst. Thank you for bringing this up! Background for me for those interested: Within a few years of struggling with chronic pain and tension headache episodes (vomiting, catch-my-breath level…

You're welcome! And thank you for expounding.

I am very protective of my hearing, so I don't take NSAIDS and I carry earplugs to every restaurant, pub, and other noisy venue. Yet I recently suffered depressing and life-degrading damage to my hearing, which is being blamed on COVID vaccine. After it happened, people came out of the woodwork saying, "Oh yeah, I've heard of that." And now, too late for many of us, the information is trickling out. National Geographic featured an article about it last month.

I've seen two of the top hearing specialists on the west coast (if not the USA), and both vehemently stated that this is a true phenomenon; one of them stated with equal assurance that information about it is being suppressed. Even vaccine experts are afraid of being "canceled."

And indeed, my experience here reflects why. I have been buried and shadow-banned at least three times for posting references to reports of COVID-vaccine-induced hearing damage. It's disgusting and dangerous behavior that will cause more people's lives to be ruined. Obviously I'm not an anti-vaxxer; if I were, I wouldn't have had all my shots and a second (ultimately disastrous and nearly useless) booster.

I hope you find relief. Here are some links to what I'm talking about yet again. There are probably more since I collected these. Unfortunately the Nat Geo one is paywalled and it seems my subscription has run out:

https://www.nationalgeographic.com/magazine/article/covid-va...

https://www.abc15.com/news/local-news/investigations/can-the...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8443418/

https://www.news-medical.net/news/20220523/Pfizer-COVID-19-v...

https://www.nbcnews.com/health/health-news/tinnitus-rare-sid...

Facebook group for victims, with several thousand members: https://www.facebook.com/groups/265035901879921/

Re: New insights into why aspirin works so well

#258

Post by unethical_ban »

zabzonk wrote: post #37
glass3 wrote: post #29

Earlier quoted context omitted.

If you haven't seen it: >consumer451 3 months ago | next [–] >I was diagnosed with arthritis at a very young age. [...] >One day I learned about modifying my diet to avoid inflammation. I greatly limited, but did not entirely eliminate, tomatoes and potatoes in my diet. >[...] https://news.ycombinator.com/item?id=34163231

unhappily, i was diagnosed with arthritis at quite an old age (60+) after happily eating tomatoes and tatties for all my life. i won't say what i think about advice like this.

Arthritis and inflammation in general can be caused by many things. For some, it can be the good one eats. Nightshades are a real problem for some people.

Re: New insights into why aspirin works so well

#259

Post by francisofascii »

neom wrote: post #224
thenerdhead wrote: post #209

Earlier quoted context omitted.

I do not. I have my personal anecdote and experiences with common painkillers and LC. I've had it since January 2021 so there wasn't really anything known when I started taking aspirin outside of the many years of research as mentioned in OP's article. Here's my experience so far. https://jondouglas.dev/long-covid/ I've swapped aspirin about a year in for nattokinase and have noticed much better management. I still t…

Just adding a +1 for long covid and aspirin, aspirin + CBD cream (Momma Canna Cream, I think only available in Canada) was a game changer for me! I rubbed the CBD cream into my head and neck and took bayer "daily" low dose aspirin till I started to feel normal again (brain fog cleared).

How long did it take?

Re: New insights into why aspirin works so well

#260

Post by neom »

francisofascii wrote: post #259
neom wrote: post #224

Earlier quoted context omitted.

Just adding a +1 for long covid and aspirin, aspirin + CBD cream (Momma Canna Cream, I think only available in Canada) was a game changer for me! I rubbed the CBD cream into my head and neck and took bayer "daily" low dose aspirin till I started to feel normal again (brain fog cleared).

How long did it take?

Seemed like it was never going away, 9 months in to "long covid" I kept saying "this needs to clear soon, it should clear soon" - I was going nuts because of the brain fog (end of 2021 into 2022). Did a lot of research, saw the clotting and inflammation research so I put myself on aspirin and CBD, after about a week and a half/2 weeks I noticed a slight improvement, about 3 months thereafter things were getting back to normal. To be perfectly honest, I'm not sure I've really ever fully recovered from covid, but hard to say if it's covid, getting older, stress. Never the less, I feel personally confident that aspirin + cbd helped.
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