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New insights into why aspirin works so well

eurekalert.org

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Re: New insights into why aspirin works so well

#31

Post by zabzonk »

jamal-kumar wrote: post #25
zabzonk wrote: post #16

Earlier quoted context omitted.

thanks, but no thanks

There's something like a downward spiral into hell that is opiates which starts with low doses like what you're on and escalates into worse and worse bullshit because you're not even trying to treat the underlying inflammation before masking the pain with opiates, and then the movement the pain is trying to prevent you from doing happens anyways and you just end up with more damage. I'm telling you these alternatives…

believe me, i know all about pain, from experience. cannabis derived products are not going to do anything, and i have no idea what you were going on about with tumeric. the only real actual pain-killers are opioids.

Re: New insights into why aspirin works so well

#32

Post by wbl »

DoreenMichele wrote: post #24

Tangentially, does anyone know how aspirin promotes bleeding? I've searched (and also searched nutrient depletions for aspirin) and I'm not really getting an answer.

COX enzymes produce a promotor of platelet activity and aspirin knocks it out. That's why they thought COX-2 selective inhibitors would be better.

Re: New insights into why aspirin works so well

#33

Post by DoreenMichele »

stouset wrote: post #30
DoreenMichele wrote: post #24

Tangentially, does anyone know how aspirin promotes bleeding? I've searched (and also searched nutrient depletions for aspirin) and I'm not really getting an answer.

It’s an antiplatelet medication. How it’s that , I haven’t the faintest.

Thank you. That gives me a place to start:

https://www.ncbi.nlm.nih.gov/books/NBK537062/

Re: New insights into why aspirin works so well

#34

Post by cfu28 »

stouset wrote: post #30
DoreenMichele wrote: post #24

Tangentially, does anyone know how aspirin promotes bleeding? I've searched (and also searched nutrient depletions for aspirin) and I'm not really getting an answer.

It’s an antiplatelet medication. How it’s that , I haven’t the faintest.

Aspirin inhibits COX-1 and COX-2 irreversibly, which decreases synthesis of thromboxane which is key to platelet aggregation and vasoconstriction

Re: New insights into why aspirin works so well

#36

Post by cfu28 »

DoreenMichele wrote: post #24

Tangentially, does anyone know how aspirin promotes bleeding? I've searched (and also searched nutrient depletions for aspirin) and I'm not really getting an answer.

Prevents arachidonic acid from being converted to thromboxane needed for platelet aggregation. Here's a diagram I find helpful of the arachidonic pathway and which drugs inhibit which parts of the pathway: https://files.mari.casa/aapathway.jpg

Re: New insights into why aspirin works so well

#37

Post by zabzonk »

glass3 wrote: post #29
zabzonk wrote: post #8

annecdata: aspirin is pretty good as an anti-inflamitory and hence pain-killer. the reason i don't take it is that it irritates the stomach, and i have enough issues with my insides as it is (irritable-bowel syndrome - not fun) i currently use cocodamol (codeine and paracetomol) to control my arthritic pain, but it isn't doing so great. at the end of the day, if you really need pain control, you probably want a pure…

If you haven't seen it: >consumer451 3 months ago | next [–] >I was diagnosed with arthritis at a very young age. [...] >One day I learned about modifying my diet to avoid inflammation. I greatly limited, but did not entirely eliminate, tomatoes and potatoes in my diet. >[...] https://news.ycombinator.com/item?id=34163231

unhappily, i was diagnosed with arthritis at quite an old age (60+) after happily eating tomatoes and tatties for all my life. i won't say what i think about advice like this.

Re: New insights into why aspirin works so well

#38

Post by jeffparsons »

drKarl wrote: post #35

When I was a kid aspirin was used for everything, from a headache to fever, etc, now no one uses it anymore, and everyone uses paracetamol and ibuprofen instead...

It's shocking to me how we still refer to paracetamol and ibuprofen in the same breath when their relative risks are so different.

Re: New insights into why aspirin works so well

#39

Post by archerx »

DoreenMichele wrote: post #28
jamal-kumar wrote: post #25

Earlier quoted context omitted.

There's something like a downward spiral into hell that is opiates which starts with low doses like what you're on and escalates into worse and worse bullshit because you're not even trying to treat the underlying inflammation before masking the pain with opiates, and then the movement the pain is trying to prevent you from doing happens anyways and you just end up with more damage. I'm telling you these alternatives…

They did not ask for health advice from random internet strangers. Trying to bully someone into following medical advice they didn't ask for is not cool.

[flagged]

Re: New insights into why aspirin works so well

#40

Post by onethought »

jeffparsons wrote: post #38
drKarl wrote: post #35

When I was a kid aspirin was used for everything, from a headache to fever, etc, now no one uses it anymore, and everyone uses paracetamol and ibuprofen instead...

It's shocking to me how we still refer to paracetamol and ibuprofen in the same breath when their relative risks are so different.

What risks are you referring to?

I think the fact that for most people there is almost no risk is why they are mentioned in the same Breathe

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