For me Aspirin takes about three times longer to reach effect compared to Ibuprofen or Paracetamol which "kicks in" after just 15 to 20 minutes. As for getting rid of a headache they're all equally efficient on me.
New insights into why aspirin works so well
161–170 of 291 posts
Re: New insights into why aspirin works so well
#162When you say in 2023 that they have "new insights" as to why a common over the counter drug works it really doesn't instill great confidence in pharma. Seems like we're still grinding up rhino horns and tiger penis and hoping for the best outcome, just that we do it with extensive testing now so we get a statistically acceptable outcome viable for marketing.
You joke but most drugs are made from interesting things. NAC's components for example are human hair and chicken feet.
Re: New insights into why aspirin works so well
#163I remember an old interview with Milton Friedman where he stated using aspirin every other day to reduce the dangers of heart attacks. My grandfather did the same. So I guess this wasn’t such a good idea after all?
my father in law (76 years old) does the same, but it's not the same kind of aspirin i'd take. Iirc there's a special version for that use. I think it's called cardio-aspirin or something? The downside is that it's an anti-coagulant, so if you bleed for any reason it will not stop bleeding as easily as without the cardio-aspirin.
It’s just a baby dosage of it 81mg.
Re: New insights into why aspirin works so well
#164Earlier quoted context omitted.
If we could reliably show that ground rhino horns and tiger penises work, we'd be using them, or finding an easily mass produced derivatives.
If they'd work we we would quickly start trying to find the one chemical in them that is responsible for that, and once successful find a way to synthesize it from cheaper to source ingredients. In the end you'd just have an ointment that says "active ingredient: acetylsalicylic acid" and it's up to the marketing department whether they want to mention rhinos or not.
Gives new meaning to Tiger balm
Re: New insights into why aspirin works so well
#165Earlier quoted context omitted.
That’s not what this site is about. Here every lane is our lane. It’s how we grow.
This site is about spreading false and misleading information under the guise of "just giving helpful advice"? Thanks but I'll continue to call out dangerous misinformation when I see it. Let's keep "reefer madness, but for pain medicine" at the fringes.
So the gold standard for “dangerous misinformation” is whatever you decide to call “dangerous misinformation”.
Do you have any “Actual Information” to back up your call?
If so, share it.
Asking for silence and defending it with buzzwords like “dangerous misinformation” adds literally zero
Re: New insights into why aspirin works so well
#166When you say in 2023 that they have "new insights" as to why a common over the counter drug works it really doesn't instill great confidence in pharma. Seems like we're still grinding up rhino horns and tiger penis and hoping for the best outcome, just that we do it with extensive testing now so we get a statistically acceptable outcome viable for marketing.
This is not about "pharma" though, where "pharma" means pharmaceutical companies.
There is nothing of any interest in aspirin for commercial pharmaceutical organizations - any money spent in research is not recoverable. They will of course focus their efforts on researching new drugs, as their shareholders would expect.
Re: New insights into why aspirin works so well
#167Earlier quoted context omitted.
If you haven't seen it: >consumer451 3 months ago | next [–] >I was diagnosed with arthritis at a very young age. [...] >One day I learned about modifying my diet to avoid inflammation. I greatly limited, but did not entirely eliminate, tomatoes and potatoes in my diet. >[...] https://news.ycombinator.com/item?id=34163231
unhappily, i was diagnosed with arthritis at quite an old age (60+) after happily eating tomatoes and tatties for all my life. i won't say what i think about advice like this.
> tatties for all my life.
Hey, a fellow Scot? ;)
Assuming so, something that might be worth considering is medical cannabis, which has been legal in the UK since 2018 - I mention it, as very few people are aware of this. Both THC oil and dried cannabis flower for vaping are available. I use it for chronic neuropathic and muscular pain, and it works amazingly well.
Alternatively, as some others have mentioned, your body may not process codeine correctly (quite a few people can't), so you may wish to try co-dydramol, a mixture of paracetamol and dihydrocodeine. I personally found dihydrocodeine to work much better than codeine.
Re: New insights into why aspirin works so well
#168When you say in 2023 that they have "new insights" as to why a common over the counter drug works it really doesn't instill great confidence in pharma. Seems like we're still grinding up rhino horns and tiger penis and hoping for the best outcome, just that we do it with extensive testing now so we get a statistically acceptable outcome viable for marketing.
This might surprise you, but we don't actually fully understand how most drugs work. Not just common OTC drugs, either, but also complex synthetic drugs used for things like autoimmune disorders, preventing organ rejection, and so on. Not just drugs that have been in use since the inception of modern medicine, but also about brand new drugs.
Often we have some idea how they work and what the internal end result appears to be, but the pathways that the drug seems to work on aren't fully understood. So we know the drug does something to that pathway, but it is to some extent a black box for us. But the fact that the drug operates on the pathway also opens new avenues for the scientists to gain a better understand of that pathway.
Modern medicine is optimized for end results. If a drug appears to work, the "how" is of secondary importance. We can always figure that out later. Sometimes we find stuff in nature, for example, like chemicals produced by fungi or bacteria, and we discover that they have medicinal properties. They nevertheless get productized as drugs, even when we don't fully understand them or the pathways they target.
Re: New insights into why aspirin works so well
#169I imagine different people tolerate different anti-inflammatory over-the-counter drugs differently. Side effects of overuse are significant however and include liver, kidney, and gastrointestinal damage (acetaminophen, ibuprofen and aspirin respectively I think with some crossover effects). Use judiciously, and only take regularly under a doctor's supervision as side effects can be minimized with additional drugs whi…
Ibuprofen and aspirin can both reliably produce internal gastrointestinal bleeds after a single dose in people with underlying digestive diseases. Over enough time with constant usage, they'll cause that in anybody.
Can confirm (anecdotally)
Ibuprofen gives me either gas or the runs.
Paracetamol works just fine - but it does have a liver effect, so it's a big no-no for hangovers.