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Polio cases in Africa linked to new oral vaccine

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Re: Polio cases in Africa linked to new oral vaccine

#24
post #6

In short: A common adverse effect from oral polio vaccine, occurring at a far lower rate in the new vaccine than in the one it replaced. Headline link makes it sound like -bad- news.

Almost makes it sound like we would have eradicated polio had we not revived with with oral vaccines.

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Re: Polio cases in Africa linked to new oral vaccine

#25

I didn't know a vaccine could CAUSE the disease it is meant to prevent. If a layman said this I would have dismissed them as a conspiracy nut. How common is this across all vaccines in general (irrespective of how low the probabilities are in each case.)

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Re: Polio cases in Africa linked to new oral vaccine

#26

I didn't know a vaccine could CAUSE the disease it is meant to prevent. If a layman said this I would have dismissed them as a conspiracy nut. How common is this across all vaccines in general (irrespective of how low the probabilities are in each case.)

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Re: Polio cases in Africa linked to new oral vaccine

#27

I didn't know a vaccine could CAUSE the disease it is meant to prevent. If a layman said this I would have dismissed them as a conspiracy nut. How common is this across all vaccines in general (irrespective of how low the probabilities are in each case.)

I don't think it's easy to summarize in a useful manner because it basically comes down to how a specific vaccine works.

For example, subunit vaccines like the whooping cough vaccine use a portion/fragment of the infectious agent, which means it is literally impossible for such a vaccine to cause the illness it is supposed to work on since there is none of that agent in the vaccine in the first place.

Attenuated vaccines, such as some polio vaccines and the MMR vaccine, include a weakened version of the infectious agent. These types of vaccines can result in a full-blown infection, especially in immunocompromised people.

So in short, the risk of a full-blown infection from a vaccine is going to depend on the type of vaccine, and I suspect there's variation within each type as well.

There's more info on the various types of vaccines at https://www.hhs.gov/immunization/basics/types/index.html

Re: Polio cases in Africa linked to new oral vaccine

#28

I didn't know a vaccine could CAUSE the disease it is meant to prevent. If a layman said this I would have dismissed them as a conspiracy nut. How common is this across all vaccines in general (irrespective of how low the probabilities are in each case.)

It depends on the vaccine.

My recollection:

There are two types of polio vaccine, one made from live germs and one made from killed germs. You cannot get polio from the killed polio version.

IIRC, polio vaccines are the primary cause of polio today.

Re: Polio cases in Africa linked to new oral vaccine

#29

I didn't know a vaccine could CAUSE the disease it is meant to prevent. If a layman said this I would have dismissed them as a conspiracy nut. How common is this across all vaccines in general (irrespective of how low the probabilities are in each case.)

This is pretty common, actually.

https://www.verywellhealth.com/what-is-a-live-virus-vaccine-... is a recent article with a partial list of common vaccines that are live. They tend to be more effective than alternative vaccines. And, unless you are immunocompromised, they are very unlikely to make you sick.

What makes the polio vaccine more complicated is that it is given orally, multiplies, passes through your body, and comes out in your feces. Which gives it a route by which it can infect people other than the person who received the vaccine. The same does not happen with injected live vaccines.

There is an inactivated polio vaccine that is given with a needle. That is used by the USA and most advanced countries. But it is more expensive, is harder to deliver (you need multiple shots on a schedule), and is less effective. It does protect the recipient against becoming paralyzed, but does not stop you from getting a mild stomach infection and passing it on in your feces where you can spread it to others. Therefore only the oral vaccination can halt an active community outbreak.

However the fact that the oral vaccine can also START a community outbreak means that we have to be careful where we use it.

Re: Polio cases in Africa linked to new oral vaccine

#30
post #2

Some amount of vaccine caused polio has for a long time been a problem. The point being made here is that this was a newer polio vaccine which attempted to avoid the risk. It's "vaccine designed to minimise vaccine-caused polio still causes a small number of cases" The second take away is, it's still better than earlier versions of the vaccine. So it could have been "reduced breakout vaccine-caused polio cases in new…

Title could start with the word Fewer it seems.

Good short fix. I like it.
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