Polio cases in Africa linked to new oral vaccine
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Re: Polio cases in Africa linked to new oral vaccine
#2Some amount of vaccine caused polio has for a long time been a problem. The point being made here is that this was a newer polio vaccine which attempted to avoid the risk.
It's "vaccine designed to minimise vaccine-caused polio still causes a small number of cases"
The second take away is, it's still better than earlier versions of the vaccine.
So it could have been "reduced breakout vaccine-caused polio cases in new vaccine deployed in Africa"
Re: Polio cases in Africa linked to new oral vaccine
#3Some amount of vaccine caused polio has for a long time been a problem. The point being made here is that this was a newer polio vaccine which attempted to avoid the risk. It's "vaccine designed to minimise vaccine-caused polio still causes a small number of cases" The second take away is, it's still better than earlier versions of the vaccine. So it could have been "reduced breakout vaccine-caused polio cases in new…
"A problem" is a bit of an understatement... at this point it's basically caused the global polio eradication effort to fail. Wild type 2 poliovirus no longer exists anywhere in the world, and all infections with it over the last couple of decades are vaccine-derived. The original plan was that everywhere would switch to a bivalent oral vaccine without the type 2 virus, any remaining vaccine-derived outbreaks could be mopped up with monovalent vaccine, and then it would finally be eradicated for real. This failed - there were widespread outbreaks and targetted vaccination just caused the number of outbreaks to increase. The new oral vaccine was the fallback plan and the fact that this is already happening with it is not a great sign.
Re: Polio cases in Africa linked to new oral vaccine
#4Some amount of vaccine caused polio has for a long time been a problem. The point being made here is that this was a newer polio vaccine which attempted to avoid the risk. It's "vaccine designed to minimise vaccine-caused polio still causes a small number of cases" The second take away is, it's still better than earlier versions of the vaccine. So it could have been "reduced breakout vaccine-caused polio cases in new…
"A problem" is a bit of an understatement... at this point it's basically caused the global polio eradication effort to fail. Wild type 2 poliovirus no longer exists anywhere in the world, and all infections with it over the last couple of decades are vaccine-derived. The original plan was that everywhere would switch to a bivalent oral vaccine without the type 2 virus, any remaining vaccine-derived outbreaks could b…
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Re: Polio cases in Africa linked to new oral vaccine
#5Earlier quoted context omitted.
"A problem" is a bit of an understatement... at this point it's basically caused the global polio eradication effort to fail. Wild type 2 poliovirus no longer exists anywhere in the world, and all infections with it over the last couple of decades are vaccine-derived. The original plan was that everywhere would switch to a bivalent oral vaccine without the type 2 virus, any remaining vaccine-derived outbreaks could b…
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I personally believe that those qualities are orthogonal.
Re: Polio cases in Africa linked to new oral vaccine
#6In short:
A common adverse effect from oral polio vaccine, occurring at a far lower rate in the new vaccine than in the one it replaced.
Headline link makes it sound like -bad- news.
Re: Polio cases in Africa linked to new oral vaccine
#7Re: Polio cases in Africa linked to new oral vaccine
#8Earlier quoted context omitted.
"A problem" is a bit of an understatement... at this point it's basically caused the global polio eradication effort to fail. Wild type 2 poliovirus no longer exists anywhere in the world, and all infections with it over the last couple of decades are vaccine-derived. The original plan was that everywhere would switch to a bivalent oral vaccine without the type 2 virus, any remaining vaccine-derived outbreaks could b…
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Eh, the oral polio vaccine is old, cheap, and kind of predates the rise of modern big pharma. Disease eradication is just a hard problem in general. The only human infectious disease that's been eradicated - smallpox - was a particularly easy target for various unique reasons, including the existence of a live vaccine that was incredible effective despite being so wildly different from the actual disease-causing virus that it couldn't easily cause serious disease in humans itself.
Re: Polio cases in Africa linked to new oral vaccine
#9Earlier quoted context omitted.
"A problem" is a bit of an understatement... at this point it's basically caused the global polio eradication effort to fail. Wild type 2 poliovirus no longer exists anywhere in the world, and all infections with it over the last couple of decades are vaccine-derived. The original plan was that everywhere would switch to a bivalent oral vaccine without the type 2 virus, any remaining vaccine-derived outbreaks could b…
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Maybe, but that kind of company probably aims its products at the First World customer.
Re: Polio cases in Africa linked to new oral vaccine
#10Earlier quoted context omitted.
"A problem" is a bit of an understatement... at this point it's basically caused the global polio eradication effort to fail. Wild type 2 poliovirus no longer exists anywhere in the world, and all infections with it over the last couple of decades are vaccine-derived. The original plan was that everywhere would switch to a bivalent oral vaccine without the type 2 virus, any remaining vaccine-derived outbreaks could b…
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We have eradicated pathogens before...