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My ADHD founder toolbox

hypatia.ca

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Re: My ADHD founder toolbox

#401

Post by cja »

FollowingTheDao wrote: post #340
zrm wrote: post #335

Earlier quoted context omitted.

The active form of B6 is the enzyme cofactor used by AADC: https://en.wikipedia.org/wiki/Aromatic_L-amino_acid_decarbox... AADC is an enzyme in the path that converts amino acids into dopamine and PEA/NMPEA (see "biosynthetic pathways" in above link), the latter of which is an endogenous structural isomer of amphetamine. You're not really making a strong case that this isn't about dopamine or that amphetamine is the…

P5P is also the cofactor for GAD1 an GAD2: https://www.uniprot.org/uniprotkb/Q99259/entry https://www.researchgate.net/publication/340492849_The_Gluta... I did not say it is not about dopamine, but it is, at a deeper level, about glutamate. Which is why coffee works so well for ADHD because the stimulant action from caffeine is produced by glutamate. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700297/ https://www.n…

Leading experts on ADHD do not say that coffee works well for ADHD

Re: My ADHD founder toolbox

#402

Post by FollowingTheDao »

eyelidlessness wrote: post #400
FollowingTheDao wrote: post #389

Earlier quoted context omitted.

You make me assumption that I’m trying to disabuse you of taking your medication. I’m not. I don’t care, take it if you want. But by not being open to other methods of treatment, you aredisabusing people of that choice. You go on and on about how you don’t think it would work, but have you ever had your B6 level tested never mind your red blood cell B6 levels? I get it, you don’t care, you found a treatment that work…

Responding to both your comments in one. > I mean you did not even bother to search for another paper. I most certainly did. The search results I got were primarily ads, and few clinical studies I found were, like the one you linked, far less bold in the results they claimed than your claim of a “cure”. > You make me assumption that I’m trying to disabuse you of taking your medication. I’m not. I don’t care, take it…

> The search results I got were primarily ads..

Maybe use PubMed and not google?

> you don’t seem to want to accept anything other than a revelation that what I need is vitamins rather than the treatment that my doctor prescribes.

I NEVER SAID THAT ONCE. Take stimulants if you want, but just because that is your choice do you need to be so outraged by the idea that B6 might work just as well?

>> But by not being open to other methods of treatment, you are disabusing people of that choice.

> Excuse me, how?

YOU: Moreover I haven’t had a single medical professional raise this possibility and with good reason.

You: But I don’t even have a strong expectation that I could expect equivalent or better management.

You: I don’t believe you.

This negative stance only feeds on this idea that medications are the only choice, the only answer, and that nutrition never works becasue "there are no studies" or "My doctor did not recommend it".

You are just shooting down the idea that this might be the root of the issue. And yet you have never even had you B6 levels tested. That is just willful ignorance. Have you worked in Nutritional Genomics? Do you even know why treating a B6 deficiency might be important not just for your behavior but your over all health? If you have a B6 deficiency and take stimulants to cover up the symptoms, what about all the other enzymes that need B6 to function?

Over and over they find B6 deficiency in ADHD. There will be no studies showing the efficacy of B6 because there is no funding for products that do not make a profit. You are on stimulants because they work and they are profitable.

Next thing they will get you to take will be Metadoxine. Ha!

https://pubmed.ncbi.nlm.nih.gov/25295645/

https://pubmed.ncbi.nlm.nih.gov/23290324/

Hmmmm...I wonder why they were trying out Metadoxine for ADHD, and wonder why it failed...oh....Metadoxine, also known as pyridoxine-pyrrolidone carboxylate. So they made a funked up version of B6? Why would all these smart science people want to make a funked up version of B6 if B6 was not linked to ADHD?

Do you think maybe they know something they do not want you to know? And maybe that is because ADHD meds brings in about $20 Billion for these companies?

Have you thought you do not want to hear anything but stimulants are the only answer for you? And that I am not talking past you but that there is no one there who wants to listen?

Re: My ADHD founder toolbox

#403

Post by FollowingTheDao »

eyelidlessness wrote: post #75
PragmaticPulp wrote: post #71

Earlier quoted context omitted.

> one month in is way too early to know if the change is long-term positive. This is especially true with stimulant medications. Agree. It's important to remind people that the effects of the first few weeks aren't like the effects for the next 10-50 years. It's especially concerning when people say the meds give them "more energy to do things" because that's more of a side effect that goes away after a while. The fo…

I’ve never experienced more energy to do things nor euphoria from my stimulant meds. They make me less anxious and allow me to muster executive function that I struggle with otherwise. Not because I’m more focused or productive or whatever else people ascribe to the drug, because I’m less overwhelmed by the world that’s loud and fast and bright and complicated and dangerous. My brain and the world around me are quiet…

> They make me less anxious

High-dose pyridoxine as an 'anti-stress' strategy

https://pubmed.ncbi.nlm.nih.gov/10859691/

Anxiolytic-like effect of pyridoxine in mice by elevated plus maze and light and dark box: Evidence for the involvement of GABAergic and NO-sGC-cGMP pathway

https://www.sciencedirect.com/science/article/abs/pii/S00913...

Re: My ADHD founder toolbox

#404

Post by eyelidlessness »

FollowingTheDao wrote: post #402
eyelidlessness wrote: post #400

Earlier quoted context omitted.

Responding to both your comments in one. > I mean you did not even bother to search for another paper. I most certainly did. The search results I got were primarily ads, and few clinical studies I found were, like the one you linked, far less bold in the results they claimed than your claim of a “cure”. > You make me assumption that I’m trying to disabuse you of taking your medication. I’m not. I don’t care, take it…

> The search results I got were primarily ads.. Maybe use PubMed and not google? > you don’t seem to want to accept anything other than a revelation that what I need is vitamins rather than the treatment that my doctor prescribes. I NEVER SAID THAT ONCE. Take stimulants if you want, but just because that is your choice do you need to be so outraged by the idea that B6 might work just as well? >> But by not being open…

> so outraged

I normally hate to quote this but it fits: calmer than you are.

> You are just shooting down the idea that this might be the root of the issue. And yet you have never even had you B6 levels tested. That is just willful ignorance.

My gosh, you’re being a jerk. I haven’t had my B6 levels tested in the last few days because it’s in the last few days and my medical appointment was canceled because I’m out of state for a family medical emergency! Have you thought about the fact that I literally physically cannot meet your expectations of an open mind and that your expectations are totally unreasonable?

Re: My ADHD founder toolbox

#405

Post by otikik »

elcritch wrote: post #396
otikik wrote: post #197

Earlier quoted context omitted.

Hi, could you give an example of the “press enter” part? I feel it would work for me but I don’t fully understand what you mean.

Sure! It can be a method to overcome procrastination. Say you’re procrastinating on starting on a new work project. Neurotypicals might just type `npm init myproj` and “hit enter” to break it down into a smaller piece. Useful and seemingly simple.. However, ADHD’ers brain may interpret “hitting enter” as akin to putting your hand on a hot stove element. You literally just can’t do it! In that case type in `npm init m…

Hey, thank you for explaining it so clearly, it makes total sense. Have a wonderful day.

Re: My ADHD founder toolbox

#406

Post by nerdyadventurer »

throwawaaarrgh wrote: post #51

I diagnosed when I was like... 8 years old. From then to 17 I was on various meds, finally gave them all up. So for about 22 years I've coped with ADHD without meds. I am a Staff Engineer and make a good living, respected in my field. Regardless of anything else, I think the key thing to remember about ADHD is that you do not need to be a high-performing human being, at all, in life. You will forget things and get di…

Does your company know that you have ADHD? If so how was there response?

Re: My ADHD founder toolbox

#407

Post by nerdyadventurer »

anshumankmr wrote: post #166
Doxin wrote: post #164

Earlier quoted context omitted.

I'm not on meds anymore. Did try them for a month though. Worked great aside from giving me stress as it wore off. Really weird to feel stressed for literally actually no reason. What it did give me is a look into what functioning normally-ish would look like, Which has helped enormously. I'm not a huge fan of medication myself, but if I were you I'd definitely give it a shot. You can always stop if it's not your thi…

I take meds for unrelated things, for allopecia, like Finasteride, Minoxidil, Saw Palmetto. I am not sure how those would interact with the medicines I saw on this thread. I also take Algae based Omega 3 semi regularly (but that stuff tastes like crayons).

Checkout these post:https://news.ycombinator.com/item?id=30557068, https://medium.com/@bladley/my-battle-with-post-finasteride-...

I also have OCD, ADHD and a PD mom, so I know the pain of being unwell. I take Fluoxetine and Ritalin. While I have not used Finasteride use them with caution, because I do not won't any one to go through any more pain due to meds.

Re: My ADHD founder toolbox

#408

Post by nerdyadventurer »

ChadNauseam wrote: post #310
hypatiadotca wrote: post #296

Earlier quoted context omitted.

Oh jeez definitely look into the potential side effects of finasteride if you haven’t already. ADHD meds have nothing on it, side effect wise.

As someone on both this is not true ime. finasteride has had no side effects for me, while adderall makes me irritable and paranoid when it wears off, not to mention the insomnia it causes.

Please see my comment : https://news.ycombinator.com/item?id=33691229

Re: My ADHD founder toolbox

#409

Post by FollowingTheDao »

eyelidlessness wrote: post #404
FollowingTheDao wrote: post #402

Earlier quoted context omitted.

> The search results I got were primarily ads.. Maybe use PubMed and not google? > you don’t seem to want to accept anything other than a revelation that what I need is vitamins rather than the treatment that my doctor prescribes. I NEVER SAID THAT ONCE. Take stimulants if you want, but just because that is your choice do you need to be so outraged by the idea that B6 might work just as well? >> But by not being open…

> so outraged I normally hate to quote this but it fits: calmer than you are . > You are just shooting down the idea that this might be the root of the issue. And yet you have never even had you B6 levels tested. That is just willful ignorance. My gosh, you’re being a jerk. I haven’t had my B6 levels tested in the last few days because it’s in the last few days and my medical appointment was canceled because I’m out…

> I haven’t had my B6 levels tested in the last few days because it’s in the last few days

I was asking if you had your B6 levels tested ever, not in the last few days.

You’re reading what I wrote much more dramatically than it is implied. The fact you think I am really telling you to run out right now and get your B6 tested is distorted.

Re: My ADHD founder toolbox

#410

Post by sprkwd »

tonyarkles wrote: post #36
artdigital wrote: post #25

Earlier quoted context omitted.

I want to emphasize this opinion. There is definitely survivorship bias, and I dislike people calling it a 'superpower'. Yes it can make you more reckless and impulsive to take risks like founding a company, but it's important to keep in mind that ADHD is a serious cognitive disability, and we should treat it as that. There is so much it messes with on a daily basis and it absolutely sucks. So much coping, self-doubt…

> Yes it can make you more reckless and impulsive to take risks like founding a company, but it's important to keep in mind that ADHD is a serious cognitive disability, and we should treat it as that. There is so much it messes with on a daily basis and it absolutely sucks. I think the r/ADHD approach on Reddit nails it: even if it did have benefits for you , please don't refer to it as a superpower because there's a…

i believe you might be me.
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