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A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

nature.com

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Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#131

Post by Beaver117 »

People weren't fat 100 years ago so what happened? We didn't just evolve to have lower self control. Something was introduced in the food/water supply that causes obesity, particularly high appetite. What can it be? HFCS? Antibiotics? PFAS? Canola oil? Some mystery chemical?

The CICO cult are a hindrance to society, obviously everyone would count calories if it didn't make them feel like they're dying. The fact is we don't know CO. And we don't know each how each persons appetite is influenced. So talking about CICO is meaningless.

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#132

Post by xctr94 »

sedeki wrote: post #117
polishdude20 wrote: post #86

Earlier quoted context omitted.

IF seems to be one of many techniques to restrict your overall calorie consumption. Each technique is suited to a different person's schedule, personality, vices etc. It's less about the chemistry happening in the body and more about the matching of diet to personality choices. As for IF while lifting? Depends on your goals.

OK! I was under the impression that it had tangible health benefits like better cardio-vascular health regardless of diet, better well-being/mood. In other words, I assumed that IF is not just good for weight-loss or weight maintenance.

The evangelists will sell IF/TRE has having every benefit under the sun. I do 16:8 for weight maintenance, but I also appreciate the morning work that I do on ketones. It's a simple regiment that has made me more aware of what I eat; but I don't think it's a panacea.

When you look at sources of compiled research such as Examine [1] or meta-analysis [2], the science on IF/TRE isn't yet solid enough to back more than the weight-loss aspect.

[1]: https://examine.com/diets/16-8-intermittent-fasting/

[2]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516560/

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#133

Post by nonrandomstring »

ChadNauseam wrote: post #75
nonrandomstring wrote: post #68

Earlier quoted context omitted.

It seems surprising that almost no progress has been made in appetite suppression since they used to prescribe amphetamines as "diet pills" in the 1950s. I found just a few spoons of stodgy porridge can keep hunger away for 6 - 8 hours.

Tons of progress has been made actually. Semaglutide works amazingly well at appetite suppression, and there are human trials going on now for drugs that seem to be even better. I wrote about it here [0]. [0]: https://chadnauseam.com/random/semaglutide-has-changed-the-w...

That's very interesting thanks for sharing.

BTW I used to be exactly like you and could eat enough to feed a regiment without gaining an ounce. My eating for Britain stopped suddenly when I hit 40 and metabolism changed. Hope you are blessed with lifelong good apetite management, but for me I had to start working on it and changing my lifestyle/willpower.

It's good to know that advances are happening for those who truly need a helping hand though.

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#134

Post by oblak »

Beaver117 wrote: post #131

People weren't fat 100 years ago so what happened? We didn't just evolve to have lower self control. Something was introduced in the food/water supply that causes obesity, particularly high appetite. What can it be? HFCS? Antibiotics? PFAS? Canola oil? Some mystery chemical? The CICO cult are a hindrance to society, obviously everyone would count calories if it didn't make them feel like they're dying. The fact is we…

You haven't heard of fat Romans?

The environment, pesticides, plastics, skinny robot aliens from the future. We just don't know!

Anything but indulgence.

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#135

Post by tsol »

zemvpferreira wrote: post #23
asciimov wrote: post #12

Earlier quoted context omitted.

Advice from a T2 Diabetic and regular Keto dieter. If you have never given up sugar before, it will take at least 6-8 weeks of non-use before the cravings go away. These will be some of the hardest weeks too. 1) everything has sugar in it, and you have to absolutely avoid it, not just sweets, fruits, juices, I'd even tell you diet drinks and artificial sweeteners too. That means no ketchup, sauces, breads, and most p…

As someone who's done every eating regimen under the sun, one top tip to get over the habit hump much quicker: water fasting. After ingesting nothing but water, coffee and electrolytes for 3-5 days your eating compulsions will be immediately reset. It's incredible how quick the effect is when you go extreme. It's not magic but it is pretty close.

I love water fasting and do it often. But it also is highly dependent on weight. If you're a lower weight already, it can be really hard to do a 3 day water fast. I used to be able to do them pretty easy, but after cutting weight it's become much harder. I do modified fasts where I take protein and fat both.

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#136

Post by tsol »

leidenfrost wrote: post #7
socialismisok wrote: post #2

I'd love to have some help with this. I was able to drop meat, most dairy, and salty junk food without problem. I eat plenty of green leafy vegetables. But sugar. Fuuuck I cannot walk past sweets. Sugar has claws in me I cannot shake. I hope we someday understand that mechanism better, maybe enough to give me a little help.

Curiously I tried something similar yet opposite: I stopped eating junk food and I started eating more leafy vegetables, but also I stopped eating seed oils (except for olive oil and chia oil which is rich in omega3), and gave myself green light to eat whatever amount I want of foods rich in proteins and fats, as long as it's not ultra processed. To my surprise, my weight hasn't skyrocketed, I feel full way faster wi…

Having had a drug problem at one point and having learned well out to titrate off of drugs, I feel it's helped me a lot with sugar. They function basically the same. You don't need it, but if you take it you feel nice. You also will then crave more, and feel sick if you don't take it in. The key isn't to stop all at once but to slowly lower the amount you take in over time and let your body slowly adjust.

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#137

Post by 0x737368 »

drowsspa wrote: post #124
0x737368 wrote: post #101

Earlier quoted context omitted.

Has nothing to do with fat people not understanding thermodynamics and has everything to do with not being able to follow the simple principle and looking for shortcuts instead.

A diet that doesn't take into account the factors that lead someone to overeat is useless by definition. If "most people can't follow this simple principle" then evidently it's a useless principle. Unless the goal is to point fingers to feel better about yourself, in which case it's pretty useful.

What are you talking about? If you eat a diet that has the required number of calories and nutrients designed for a healthy-weight person, your body weight will drop accordingly.

The factors that lead someone to overeat is a totally different question the answer to which should be figured out by themselves or maybe their psychologist. In most cases it's not that dire though, once their initial withdrawal from fast food stops people stop having these impulses to reach for a doughnut each time they're inconvenienced. In any case, your problems in life should be treated by dealing with the problems directly and not making themselves feel better by stuffing their face.

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#138

Post by xctr94 »

bogota wrote: post #57
drowsspa wrote: post #9

I've been hitting the gym for a few months now, and one thing that completely blew my mind was the existence of hypercalorics. Imagine that, not being able to eat a lot (specially carbs) and having to resort to these solutions. Point being, people like to spew out CICO as if fat people just don't understand thermodynamics. What I've found is that matters is appetite: some people just get full way faster than others.…

Lol stop making life complex nothing about your comment says CICO is wrong. Self control on the other hand is a problem that a lot of people have. But im sure we will find the .1% of random issues to talk about instead. People love to say its easy for you or make up all kinds of excuses. A person i dated in the pst liked to complain about how she couldn’t lose weight because of all these genetic issues. Both of her p…

You're being downvoted for having a bad attitude, victim-blaming in a system not designed for healthy weight, and for generally not understanding this is a nice forum. This isn't Reddit.

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#139

Post by xctr94 »

lob_it wrote: post #84
drowsspa wrote: post #9

I've been hitting the gym for a few months now, and one thing that completely blew my mind was the existence of hypercalorics. Imagine that, not being able to eat a lot (specially carbs) and having to resort to these solutions. Point being, people like to spew out CICO as if fat people just don't understand thermodynamics. What I've found is that matters is appetite: some people just get full way faster than others.…

Being on prescription meds is almost like the junkie paraphernalia with shooting up insulin and popping high bloodpressure meds. Doesn't is sound like a biological crutch for low-quality habits (fake food, cascading health issues, unhealthy environments,etc)? Hormone treatments appear to be guinea pig experiments with lifelong consequences.

Sadly, it's quite hard to fix the environment, since we're communally invested into the current system.

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#140

Post by adrian_b »

drowsspa wrote: post #121
adrian_b wrote: post #39

Earlier quoted context omitted.

In my opinion, the differences in appetite are caused mostly by the differences in the type of food eaten, and not by the differences between humans. In my search for a diet that would allow me to avoid gaining weight, the main successes were achieved by replacing various kinds of food that were tasty, but which did not satiate me before eating huge amounts of them, with other kinds of food that are also tasty, but w…

But that right there is a difference between you and other humans. The idea of "searching for a diet that allows you to gain weight" is absolutely alien to me. I can easily get to 5000 calories a day without even thinking about it, while you have to make a conscious effort to reach (I assume) much less than that. My sister and I grew up with the same diet. We didn't starve, but neither of us had lots of access to jun…

I think that you have misread my comment.

I have said "a diet to avoid gaining weight", not "a diet that allows gaining weight".

If I eat more than 1900 ... 2000 kcal per day, I gain weight rapidly, so the problem was reducing the amount of energy intake so much, while ensuring an adequate daily intake of proteins and of any other essential nutrients, and without feeling that I am starving.

I agree that there are differences between people and there are also differences for a single human depending on circumstances, e.g. in many cases when you are ill you lose your appetite.

Nevertheless, for the same human, different foods containing the same amount of energy can behave extremely differently from the point of view of causing satiety, both immediately after the meal and some hours later.

For remaining satiated many hours after the meal, at equal energy content food with higher content of proteins and/or fat and/or fiber is more effective.

For being satiated immediately after the meal, at equal nutrient composition food that is more consistent and requires prolonged chewing causes satiety much faster than soft food such as creams, mashed potatoes, ground meat and the like.

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