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A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

nature.com

81–90 of 162 posts

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#81

I'd love to have some help with this. I was able to drop meat, most dairy, and salty junk food without problem. I eat plenty of green leafy vegetables. But sugar. Fuuuck I cannot walk past sweets. Sugar has claws in me I cannot shake. I hope we someday understand that mechanism better, maybe enough to give me a little help.

> I was able to drop meat, most dairy, and salty junk food without problem.

You are doing this completely in reverse. You need to drop sugar & carbs. And eat fatty-meat/low-carb.

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#82
I read a lot of good things about intermittent fasting. Is there a good canonical resource if I want to try it?

Note that I am lifting weighs 3 times per week. Is IF still a good idea...?

I don't feel confident that this is something that I can lift with my GP, as it is not part of their standard set of guidelines (?)

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#83
post #31
post #9

I've been hitting the gym for a few months now, and one thing that completely blew my mind was the existence of hypercalorics. Imagine that, not being able to eat a lot (specially carbs) and having to resort to these solutions. Point being, people like to spew out CICO as if fat people just don't understand thermodynamics. What I've found is that matters is appetite: some people just get full way faster than others.…

> What I've found is that matters is appetite: some people just get full way faster than others. This is a half truth. If you cut down portion size your stomach will shrink over time. I eat a lot less before feeling full now, and I only changed my life a year ago. It's also important that you eat stuff that makes you feel full, fibers and greens. Changing diet also changed my taste, so I crave more healthy things now…

[deleted]

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#84
post #9

I've been hitting the gym for a few months now, and one thing that completely blew my mind was the existence of hypercalorics. Imagine that, not being able to eat a lot (specially carbs) and having to resort to these solutions. Point being, people like to spew out CICO as if fat people just don't understand thermodynamics. What I've found is that matters is appetite: some people just get full way faster than others.…

Being on prescription meds is almost like the junkie paraphernalia with shooting up insulin and popping high bloodpressure meds.

Doesn't is sound like a biological crutch for low-quality habits (fake food, cascading health issues, unhealthy environments,etc)?

Hormone treatments appear to be guinea pig experiments with lifelong consequences.

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#85
post #9

I've been hitting the gym for a few months now, and one thing that completely blew my mind was the existence of hypercalorics. Imagine that, not being able to eat a lot (specially carbs) and having to resort to these solutions. Point being, people like to spew out CICO as if fat people just don't understand thermodynamics. What I've found is that matters is appetite: some people just get full way faster than others.…

Uh huh. I've heard all the excuses. I am sure fat people understand thermodynamics just fine. What they lack is restraint. Never met a fat person with sane eating habits

There are no fat people during famines or in work camps, that's all we need to know to know what is true.

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#86
post #82

I read a lot of good things about intermittent fasting. Is there a good canonical resource if I want to try it? Note that I am lifting weighs 3 times per week. Is IF still a good idea...? I don't feel confident that this is something that I can lift with my GP, as it is not part of their standard set of guidelines (?)

IF seems to be one of many techniques to restrict your overall calorie consumption. Each technique is suited to a different person's schedule, personality, vices etc. It's less about the chemistry happening in the body and more about the matching of diet to personality choices.

As for IF while lifting? Depends on your goals.

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#87
post #50
post #31

Earlier quoted context omitted.

> What I've found is that matters is appetite: some people just get full way faster than others. This is a half truth. If you cut down portion size your stomach will shrink over time. I eat a lot less before feeling full now, and I only changed my life a year ago. It's also important that you eat stuff that makes you feel full, fibers and greens. Changing diet also changed my taste, so I crave more healthy things now…

> It's also important that you eat stuff that makes you feel full, fibers and greens. Changing diet also changed my taste, so I crave more healthy things now, while the food I used to eat honestly don't appeal to me any longer or tastes empty. Having tried this, by basically eating a lot of carrots, its uh, not the same as being full/satiated. Feeling like your stomach is full is just a completely different feeling f…

not to get down in the weeds but carrots aren't that fibrous, but their *available fiber content goes up 2.5x when you cook them, from about 2g per stick to 5g. leafy greens, especially kale, are better for filling up. and you still need protein and fat on top of that.

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#88

Earlier quoted context omitted.

Advice from a T2 Diabetic and regular Keto dieter. If you have never given up sugar before, it will take at least 6-8 weeks of non-use before the cravings go away. These will be some of the hardest weeks too. 1) everything has sugar in it, and you have to absolutely avoid it, not just sweets, fruits, juices, I'd even tell you diet drinks and artificial sweeteners too. That means no ketchup, sauces, breads, and most p…

As someone who's done every eating regimen under the sun, one top tip to get over the habit hump much quicker: water fasting. After ingesting nothing but water, coffee and electrolytes for 3-5 days your eating compulsions will be immediately reset. It's incredible how quick the effect is when you go extreme. It's not magic but it is pretty close.

Yep. I had an unbelievable sweet tooth since I was a teenager. I was having 10+ cans of coke per day on top of multiple king size candy bars. When I was ~30 I did a 36 hour fast and afterwards has 0 desire to have anything sweet for the very first time in my adult life.

It came back a few weeks later, but over a few years I tried fasting again and it would go away every single time. Now I try to avoid sweets as much as I can but when old habits creep back in I just have a fast and it goes away.

I don't really fast for any reason other than knowing it will take the sweet tooth away—and generally make me want to eat healthier.

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#89
post #35

Earlier quoted context omitted.

Hormones, appetite, metabolic diseases are all orthogonal to CICO. These can have an effect on how many calories you burn or how many calories you crave but at the end of the day, CICO is still law.

> CICO is still law. Calories are a measure chemical energy, not mass. Our digestive systems don't get anywhere near e=mc^2 in their efficiency. The conservation law is MIMO; calories are way more complicated. For example, people who extol CICO rarely take into account the fact that poop has a variable amount of chemical energy, which depends on a huge variety of factors including gut flora, hydration and fiber intak…

And yet Mark Haub[0] ate a diet of Twinkies (and other convenience store garbage food) to a caloric deficit and lost 27lbs in 10 weeks while all of his health metrics improved.

Trying to be super precise about calories may be complicated, but nobody has to do that to reach a caloric deficit anyway so who cares. Eat less than you need by any reasonable ball park metric and you will lose weight, it's that simple.

The hard part is that for some reason a large percentage of the population can't regulate their intake naturally because what they require for calories to be a healthy weight is misaligned with what they are compelled to consume.

[0] http://www.cnn.com/2010/HEALTH/11/08/twinkie.diet.professor/...

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#90
post #31

Earlier quoted context omitted.

> What I've found is that matters is appetite: some people just get full way faster than others. This is a half truth. If you cut down portion size your stomach will shrink over time. I eat a lot less before feeling full now, and I only changed my life a year ago. It's also important that you eat stuff that makes you feel full, fibers and greens. Changing diet also changed my taste, so I crave more healthy things now…

For increased satiety, even when eating little, an additional factor is that the food should not be too soft, like most of the industrially made food is, but it should need some time of vigorous chewing. There are many vegetables, fruits and nuts that require a decent amount of chewing. There are also some kinds of home-made bread that require much more chewing than the industrial soft bread, while also being much ta…

"Nature will castigate those who don't masticate." - https://en.wikipedia.org/wiki/Horace_Fletcher
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