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Is early-onset cancer an emerging global epidemic?

nature.com

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Re: Is early-onset cancer an emerging global epidemic?

#231

Earlier quoted context omitted.

It would be nice to have this information to see if any trends are discovered (all of this is theoretical, I question whether measuring excreted compounds rather than stores is is relevant but that’s a separate point) however it is unclear what value this information will provide and seems unlikely it will generate anything actionable. With that in mind, it’s hard to justify the colossal costs that would be involved…

Hmm, you could use that argument to dissuade all of scientific research. Science is zero sum, if we devote resources to it then you are taking them from someone else! But at the end of the day we all know there are significant potential benefits to this type of testing. Not only that, more demand can increase jobs & labs in the first place. Just because the system is dysfunctional is not a good argument for ceasing p…

Suggesting we perform niche lab examinations annually on the entire population is not scientific research, that’s jumping straight into a screening program.

Such an initiative would require more lab resources than currently exists in the US.

I’m questioning whether this is the best use of $100-200 billion a year. Instead, I suggested a small study (appropriately powered) to further investigate.

Re: Is early-onset cancer an emerging global epidemic?

#232

Earlier quoted context omitted.

> still smoking, drinking alcohol, living in polluted areas and eating red meat One of these is not like the others. I can decide to not smoke, not drink alcohol and not eat red meat. It is a personal choice, and my choice doesn’t affect the health outcomes of those around me. (Mostly. Second hand smoke is a thing, but we did a lot society wise to act against that.) On the other hand living in poluted areas is absolu…

Well people can certainly move to some extent. Nobody with functional brain considers metropoles to be healthy place to live. People stay there mostly for the money, I know I do and I accept the risks (and working on improving the situation). Moving to mountainous/overall remote regions is relatively cheap. But people like easy life, close work, shopping, services and so on. World is certainly not as binary as you pa…

Most people don't even think about the impact where they live has in their health

Re: Is early-onset cancer an emerging global epidemic?

#233

> "However, the effects of individual exposures remain largely unknown. To study early-life exposures and their implications for multiple cancer types will require prospective cohort studies with dedicated biobanking and data collection technologies." What that means is analytical body-burden data collection should be a medical norm, for a variety of substances: polychlorinated biphenyls, triazine herbicides (atrazin…

Don't hold your breath. One example:

Coronary calcium deposit scans are cheap and extremely effective at giving a probabilistic window of possible future heart attack, but doctors don't order them prior to a CVD event, and insurance doesn't cover them as a pre-CVD elective.

Instead we're told: We have no way of knowing if or when you'll experience infarction, it's one of God's Great Mysteries. Just don't eat eggs and pray.

You're absolutely right, but the entire medical industry has no intention of actually reducing mortality. It's a cash grab from top to bottom, and preventative monitoring of the kind you suggest already has precedent in coronary calcium scanning. It's not going to happen if it reduces the overall predicted revenue per patient.

In the same way that a single triple-bypass surgery is far more lucrative than a hundred coronary calcium scans, a full course of cancer treatment is absurdly more profitable than regular tissue carcinogen testing.

Re: Is early-onset cancer an emerging global epidemic?

#235
post #233

> "However, the effects of individual exposures remain largely unknown. To study early-life exposures and their implications for multiple cancer types will require prospective cohort studies with dedicated biobanking and data collection technologies." What that means is analytical body-burden data collection should be a medical norm, for a variety of substances: polychlorinated biphenyls, triazine herbicides (atrazin…

Don't hold your breath. One example: Coronary calcium deposit scans are cheap and extremely effective at giving a probabilistic window of possible future heart attack, but doctors don't order them prior to a CVD event, and insurance doesn't cover them as a pre-CVD elective. Instead we're told: We have no way of knowing if or when you'll experience infarction, it's one of God's Great Mysteries. Just don't eat eggs and…

I would take a citation on literally any single one of your statements

Re: Is early-onset cancer an emerging global epidemic?

#236

Earlier quoted context omitted.

It would be nice to have this information to see if any trends are discovered (all of this is theoretical, I question whether measuring excreted compounds rather than stores is is relevant but that’s a separate point) however it is unclear what value this information will provide and seems unlikely it will generate anything actionable. With that in mind, it’s hard to justify the colossal costs that would be involved…

> Young ( Remind me to never use you as a medical provider.

Here are some resources to read.

https://europepmc.org/article/nbk/nbk82767#_vaphysical_s5_

https://www.cfp.ca/content/cfp/63/11/824.full.pdf

https://www.bmj.com/content/345/bmj.e7191?ijkey=34070a9e7bf5...

Re: Is early-onset cancer an emerging global epidemic?

#237
post #233

> "However, the effects of individual exposures remain largely unknown. To study early-life exposures and their implications for multiple cancer types will require prospective cohort studies with dedicated biobanking and data collection technologies." What that means is analytical body-burden data collection should be a medical norm, for a variety of substances: polychlorinated biphenyls, triazine herbicides (atrazin…

Don't hold your breath. One example: Coronary calcium deposit scans are cheap and extremely effective at giving a probabilistic window of possible future heart attack, but doctors don't order them prior to a CVD event, and insurance doesn't cover them as a pre-CVD elective. Instead we're told: We have no way of knowing if or when you'll experience infarction, it's one of God's Great Mysteries. Just don't eat eggs and…

If they’re cheap and you’re concerned couldn’t you just get one out of pocket ?

Re: Is early-onset cancer an emerging global epidemic?

#238
post #233

> "However, the effects of individual exposures remain largely unknown. To study early-life exposures and their implications for multiple cancer types will require prospective cohort studies with dedicated biobanking and data collection technologies." What that means is analytical body-burden data collection should be a medical norm, for a variety of substances: polychlorinated biphenyls, triazine herbicides (atrazin…

Don't hold your breath. One example: Coronary calcium deposit scans are cheap and extremely effective at giving a probabilistic window of possible future heart attack, but doctors don't order them prior to a CVD event, and insurance doesn't cover them as a pre-CVD elective. Instead we're told: We have no way of knowing if or when you'll experience infarction, it's one of God's Great Mysteries. Just don't eat eggs and…

“Just don't eat eggs and pray.”

If you avoid smoking, have a healthy diet, get adequate exercise and consequently maintain a healthy weight you’ll do far more to prognosticate your MI risk than a calcium score.

Re: Is early-onset cancer an emerging global epidemic?

#239
post #117
post #74

Earlier quoted context omitted.

> Cancer is easily explained from an evolutionary optimization perspective Anything that "easily explains" cancer should be thrown right out as unscientific. Cancer is many diseases, many of which are profoundly different from the others in both mechanisms of action and causes. I kindly ask that you don't use such confident sounding language, either deluding yourself or others into believing your statements as true,…

> Anything that "easily explains" cancer should be thrown right out as unscientific. Thank you. As someone who's recently lost a loved one to cancer, I've lost count of how many times I've wanted to choke people for coming out with these "simple cancer theories".

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Re: Is early-onset cancer an emerging global epidemic?

#240

> "However, the effects of individual exposures remain largely unknown. To study early-life exposures and their implications for multiple cancer types will require prospective cohort studies with dedicated biobanking and data collection technologies." What that means is analytical body-burden data collection should be a medical norm, for a variety of substances: polychlorinated biphenyls, triazine herbicides (atrazin…

Even Nature stated microplastics are everywhere, yet we do not know what effects it will have. https://www.nature.com/articles/d41586-021-01143-3

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