221–230 of 280 posts
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I don't know what science you need to understand a system that is constantly active and is never fully allowed to rest will develop dysfunction. Anyway, as the sibling reply says, there is plenty of reputable research available to satisfy your curiosity if you wish.
Explain heartbeats?
> "However, the effects of individual exposures remain largely unknown. To study early-life exposures and their implications for multiple cancer types will require prospective cohort studies with dedicated biobanking and data collection technologies." What that means is analytical body-burden data collection should be a medical norm, for a variety of substances: polychlorinated biphenyls, triazine herbicides (atrazin…
It would be nice to have this information to see if any trends are discovered (all of this is theoretical, I question whether measuring excreted compounds rather than stores is is relevant but that’s a separate point) however it is unclear what value this information will provide and seems unlikely it will generate anything actionable. With that in mind, it’s hard to justify the colossal costs that would be involved…
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It would be nice to have this information to see if any trends are discovered (all of this is theoretical, I question whether measuring excreted compounds rather than stores is is relevant but that’s a separate point) however it is unclear what value this information will provide and seems unlikely it will generate anything actionable. With that in mind, it’s hard to justify the colossal costs that would be involved…
>I question whether measuring excreted compounds rather than stores is relevant I would have to figure that chemicals sitting in fat cells that rarely divide are probably not causing cancer. Cancer occurs mostly in epithelial tissue; in my case, the germ cell. Excreted compounds are probably a better measure of actual blood levels. I'm not a nephrologist or anything, though. >A small prospective study will almost cer…
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It would be nice to have this information to see if any trends are discovered (all of this is theoretical, I question whether measuring excreted compounds rather than stores is is relevant but that’s a separate point) however it is unclear what value this information will provide and seems unlikely it will generate anything actionable. With that in mind, it’s hard to justify the colossal costs that would be involved…
> Young ( How does letting people have undiagnosed cancer in their 30s and 40s fit in with this?
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> Young ( Tell this to my mom.
I am sorry for whatever happened/happens to your mom. That being said, when looking at cold hard data, this is a valid point. We all have various weird stuff in us, the older the more. Cystes, weird bulges, benign cancers that wont kill us for 50 years. If you are a male say above 40 or 50, you probably have some very early (or not) prostate cancer. Often you need an invasive procedure to get more info. Even then its…
>> Increased use of screening programmes has contributed to this phenomenon to a certain extent, although a genuine increase in the incidence of early-onset forms of several cancer types also seems to have emerged. How do they separate these two. Early testing is becoming more common so you expect to see more cancer simply due to looking for it. Doc: Early screening has increased the 5-year survival rate for various…
The only cancer routinely screened for in people under 50 is cervical cancer. Even then, the test detects precancerous lesions mainly. As such, ascertainment bias is not a major methodological concern.
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Autophagy keeps getting brought up with such pseudoscientific bullshit explanations that I can't help but see it as snake oil. Furthermore, depending on who is describing it, the window for autophagy to kick in is anywhere from 8-48+ hours.
There is a lot of "bro-science" out there concerning autophagy for sure, but it is definitely a thing. Yoshinori Ohsumi won the Nobel Prize in Physiology or Medicine in 2016 for "his discoveries of mechanisms for autophagy" ( https://www.nobelprize.org/prizes/medicine/2016/summary/ ).
In other words, the question isn't whether autophagy exists. The question is over whether fanatical "one-weird-trick" claims about autophagy are true and, further, what the impact actually is and compared to what.
For example, autophagy is happening all the time, not just during during starvation. And it hasn't been demonstrated that fasting for 3 days to increase autophagy levels has a net benefit versus eating a nutrient-rich diet during that timeframe.
Instead we just get vague but lofty claims in forum posts.
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It would be nice to have this information to see if any trends are discovered (all of this is theoretical, I question whether measuring excreted compounds rather than stores is is relevant but that’s a separate point) however it is unclear what value this information will provide and seems unlikely it will generate anything actionable. With that in mind, it’s hard to justify the colossal costs that would be involved…
> Young ( How does letting people have undiagnosed cancer in their 30s and 40s fit in with this?
If you develop cancer in your 30s (sadly too many people) a physical exam or blood test almost certainly wouldn’t have made the difference.
We have mammograms for breast cancer and women > 40. Unfortunately there isn’t enough evidence to support a screening program for people younger than that where the pretest probability for malignancy is so low and there are harms associated with tests.
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Yeah, especially young people do have it bad. One interesting thing is that as society becomes more and more feminist, it's the young women who fare the worst, and especially the demographics most likely to be intersectional activists. Maybe not all ideologies are good for us? At a quick glance, a lot of the intersectional feminist/activist modes of thought seem to be the polar opposites of what eg. cognitive behavio…
> At a quick glance, a lot of the intersectional feminist/activist modes of thought seem to be the polar opposites of what eg. cognitive behavioral therapy What a non sequitur. Why would feminism and stoicism have any incompatibilities?
A woman fighting against feminism is a woman fighting against responsibility for herself.
1. Yes incidence of cancer in 25-49 year olds has increased 22% from 1993 to 2018 - but that is 22% on a very low number which means it is still a very low number. When you account for increased screening, greater awareness, and better testing, the increase is likely even smaller.
https://www.cancerresearchuk.org/health-professional/cancer-...
2. Better treatment (and more effective screening) means mortality rates per 100k from all cancers in 25-49 has dropped c.40% over the same period (despite higher incidence).
https://www.cancerresearchuk.org/health-professional/cancer-...
So whilst this is obviously important to study. At least the UK data doesn't seem too terrifying but I m no expert.