Live data from Hacker News

Is early-onset cancer an emerging global epidemic?

nature.com

161–170 of 280 posts

Re: Is early-onset cancer an emerging global epidemic?

#162
post #3

>> Increased use of screening programmes has contributed to this phenomenon to a certain extent, although a genuine increase in the incidence of early-onset forms of several cancer types also seems to have emerged. How do they separate these two. Early testing is becoming more common so you expect to see more cancer simply due to looking for it. Doc: Early screening has increased the 5-year survival rate for various…

The only cancer routinely screened for in people under 50 is cervical cancer. Even then, the test detects precancerous lesions mainly. As such, ascertainment bias is not a major methodological concern.

Re: Is early-onset cancer an emerging global epidemic?

#163

Earlier quoted context omitted.

Still not sure how post-Covid, we haven't concluded that improving indoor ventilation should be a massive public health priority.

Because it's difficult. How do you solve for this problem in a house without internal ducting in temperature extremes throughout the year?

I'm curious, how long has ventilation ducting been part of housing codes, in other words how old are houses that have that problem?

Re: Is early-onset cancer an emerging global epidemic?

#164
post #157

> "However, the effects of individual exposures remain largely unknown. To study early-life exposures and their implications for multiple cancer types will require prospective cohort studies with dedicated biobanking and data collection technologies." What that means is analytical body-burden data collection should be a medical norm, for a variety of substances: polychlorinated biphenyls, triazine herbicides (atrazin…

Is this even worth doing when people are still smoking, drinking alcohol, living in polluted areas and eating red meat? These are all known risk factors with large effects on cancer risk in younger people. I think the effort is better spent as follows: - ban sale of combustible tobacco products - ban advertising of alcoholic beverages

has smoking, drinking, and eating red meat gone up in the past several decades? because, according to the first sentence of the abstract early onset cancers have gone up in the past several decades.

Re: Is early-onset cancer an emerging global epidemic?

#165
post #3

>> Increased use of screening programmes has contributed to this phenomenon to a certain extent, although a genuine increase in the incidence of early-onset forms of several cancer types also seems to have emerged. How do they separate these two. Early testing is becoming more common so you expect to see more cancer simply due to looking for it. Doc: Early screening has increased the 5-year survival rate for various…

Early-stage cancer survivorship rates are much higher, and early detection catches cancers at an earlier stage. Studies have been done that show the benefit of early screening, separate from the bias.

Re: Is early-onset cancer an emerging global epidemic?

#166

I feel like there has been a great increase in mental health issues: anxiety, depression, etc., especially among youth. I don’t recall these being major issues from when I was a youth in the late 80s and early 90s. I’m told that I’m wrong and people just didn’t talk about it so I wasn’t aware of it. But even amongst close family members and friends it wasn’t a thing. Now, I’ve seen some claim it is the post 9/11 worl…

We know for a fact that social media causes these issues, thanks to the leaking of internal Facebook documents to the WSJ[1]. Whether or not it's the only source of the rise of mental illness isn't clear, but it's a huge factor for sure.

[1] https://www.wsj.com/articles/the-facebook-files-11631713039

Re: Is early-onset cancer an emerging global epidemic?

#167

Earlier quoted context omitted.

How to really take care of the microbiome?

Sandor Ellix Katz has some fantastic books about fermentation. Really, really suggest checking them out. One thing that stuck out to me was when he talked about the relationship between people and their environment. How health is not in a vacuum, but in constant negotiation and collaboration with the world around you. He uses this to suggest fermenting things yourself, to engage in this process with the microbes in y…

One other aspect is also soap. Many people say it damages the microbiome in your skin

Re: Is early-onset cancer an emerging global epidemic?

#169

I feel like there has been a great increase in mental health issues: anxiety, depression, etc., especially among youth. I don’t recall these being major issues from when I was a youth in the late 80s and early 90s. I’m told that I’m wrong and people just didn’t talk about it so I wasn’t aware of it. But even amongst close family members and friends it wasn’t a thing. Now, I’ve seen some claim it is the post 9/11 worl…

I don't remember hearing much about anxiety or depression, but do remember hearing about things like alcoholism, domestic violence, and 'laziness.' I'm pretty sure these are largely the same psychological issues- it's just people used to hide it, and deny it even to themselves- so you would only see the resulting dysfunction. Nowadays people are getting a diagnosis and treatment rather than just silently suffering and hiding it.

Re: Is early-onset cancer an emerging global epidemic?

#170
post #92

If we're going to throw out random theories for the cause like diet and pollution, what about all the volatile chemicals off-gassing from freshly manufactured goods?

Getting an air quality monitor was enlightening and terrifying. My child’s room (which unfortunately doesn’t have great ventilation) would sometimes hit 4000 ppb VOCs, which I tracked down to some of her stuffed animals…

Ventilation got worse in the 70s as there was a big push to eliminate leaks in houses to improve HVAC efficiency.
Post reply on HN