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Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

nature.com

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Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

#101

Post by carschno »

EmilyHughes wrote: post #30
mtlmtlmtlmtl wrote: post #26

Earlier quoted context omitted.

Yeah, drugs feel great, news at 11. If psychiatry was just a matter of giving people a constant buzz, it would be solved a century ago. I'm not judging you for wanting to be high all the time, I've been there myself. But be intellectually honest and call it that, at least. Because it's not some kind of psychological panacea, and I wish people would stop implying it is. And yes, I've tried it. It made me high, but gen…

Trust me I tried all kinds of drugs and psychedelics are not the kind that get you hooked. Stimulants are especially addictive in my opinion. Psychs are the kind of drugs you say I have enough for a while if you overdo. On top of it they build tolerance immediately.

That's hardly a counterargument. GP said you were high all the time, that's different from being addicted. There is some overlap, depending on the substance, but also significant difference. Think of nicotine, caffeine (addictive, but no high) vs psilocybin (high but arguably not addictive).

Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

#102

Post by mtlmtlmtlmtl »

eurasiantiger wrote: post #45
mtlmtlmtlmtl wrote: post #26

Earlier quoted context omitted.

Yeah, drugs feel great, news at 11. If psychiatry was just a matter of giving people a constant buzz, it would be solved a century ago. I'm not judging you for wanting to be high all the time, I've been there myself. But be intellectually honest and call it that, at least. Because it's not some kind of psychological panacea, and I wish people would stop implying it is. And yes, I've tried it. It made me high, but gen…

Uh, so you took a break from your ADHD medication to microdose? And you claim it is the microdose that made you less productive? I posit you need to take a microdose with your normal ADHD medication, otherwise the anecdote is meaningless even as a personal reference.

No, I wasn't on medication at the time, couldn't get a script. I was looking for possible replacements, and a few psychedelics(LSD and 2C-B to name a couple) have psychostimulant properties. The idea was to try a few different regimens:

True microdose alone: no noticable effect on concentration, and some worsening.

Subpsychedelic yet strong enough doses to have stimulant effects: significant effect, but working memory was somewhat impaired. Impulsivity also increased.

Various conventional but obscure RC stimulants: some were highly effective, even more so than D-amp or mph. But it wasn't possible to rule out long term cardiotoxic effects like valvulopathy, so I didn't stick to them for safety reasons.

Then I did some limited trials with said stims + a true microcode, this just made me extremely scatterbrained and I quickly discontinued.

Eventually I decided even if I found something, which I had, I couldn't safely use it long term anyway. I cleaned up my act long enough to get real meds.

Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

#103

Post by failTide »

drekipus wrote: post #71

How does one even get contacts to consider this (in a safe manner)? One thought about this and I'd actually consider myself fairly in tune and at peace with my inner self already, so I'd be curious to see how it could help me deal with some of my ruts I get in from time to time. Alcohol definitely isn't helping

Go to shroomery.org - your best bet is to learn how to grow them. It's an awesome hobby in general, and you can grow non-psychedelic mushrooms as well if you just want to get the hang of it.

https://www.shroomery.org/forums/showflat.php/Number/2192202... isn't a terrible place to start.

Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

#104

Post by danielunited »

Microdosing is great but not for everyone. It can actually increase your anxiety if you take too high a dose. Personally, I take a micro dose of LSD every other Friday, drink a cup of coffee and hit the gym. It does wonders. And definitely not addicting.

Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

#106

Post by [deleted] »

YeGoblynQueenne wrote: post #75
henriquemaia wrote: post #32

Earlier quoted context omitted.

That's an uncharitable reading. OP is just sharing what works with her/him. Which is ok. From what I understood from your comment, for you it doesn't. Which is ok too, as now you know yourself a bit better. Two personal experiments with very different outcomes. There's no need for moral judgments either way.

Does "if it works for you" also go for things like aspirin, antihistamines, antihypertensives, antibiotics, etc? I've never heard anyone say "if aspirin works for you then take it, but it doesn't work for me". I've only heard this kind of thing said for things like homeopathy, astrology, accupuncture, osteopathy, and microdosing, of course. Hence, I'm very skeptical. [Edit: OK, I've heard people say that aspirin does…

[deleted]

Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

#107

Post by thegreatdukd »

schappim wrote: post #23

TL;DR (via GPT3): Microdosing with psilocybin mushrooms did not have any positive effects on well-being, creativity, or cognitive function. The only noticeable effects were subjective changes and altered EEG rhythms.

What did you add as an input to GPT-3 and what was your prompt? Have you considered some smaller models like Longformer or Big Bird with fine-tuning on research papers?

Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

#108

Post by dkarl »

YeGoblynQueenne wrote: post #93
honeybadger1 wrote: post #64

I have been interested for quite some time to dabble with psilocybin but just haven't yet had the chance with buddies(outside of a work related traveling event) to do so. I absolutely refuse to try anything like this outside of an environment I have some level of control in or trust in the people around me(not the general public I.E: Bars, clubs, Vegas, etc). Any advice on what to avoid for a first timer from any exp…

I would say that if you want to maintain your cognitive function at peak efficiency your best bet is to not do anything that has a chance to affect it negatively, like doing drugs. An "experienced person" in this case will not help you because it means someone who's been doing drugs for a while and there is at least a chance that their cognitive function is impaired and that you shouldn't trust their judgement.

I haven't tried psychedelics yet for the same reason. The people I know who offer them to me don't show any level of care or responsibility when it comes to dosing themselves. For example, they'll buy drugs from people they've never met before, random people they run into in bars and clubs. I haven't yet personally met anybody who takes drugs who is as careful as I would like to be.

Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

#109

Post by BossingAround »

EmilyHughes wrote: post #100
BossingAround wrote: post #92

Earlier quoted context omitted.

How do you define "psychoactive"?

Anything that influences your psyche in an obvious way.

Isn't Aspirin psychoactive in the same way? I.e. it takes away pain, which influences your psyche in an obvious way.

Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

#110

Post by goodoldneon »

danielunited wrote: post #104

Microdosing is great but not for everyone. It can actually increase your anxiety if you take too high a dose. Personally, I take a micro dose of LSD every other Friday, drink a cup of coffee and hit the gym. It does wonders. And definitely not addicting.

What's your dose and what are some of the benefits you get?
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