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Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

nature.com

71–80 of 303 posts

Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

#71
How does one even get contacts to consider this (in a safe manner)?

One thought about this and I'd actually consider myself fairly in tune and at peace with my inner self already, so I'd be curious to see how it could help me deal with some of my ruts I get in from time to time.

Alcohol definitely isn't helping

Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

#72

How does one even get contacts to consider this (in a safe manner)? One thought about this and I'd actually consider myself fairly in tune and at peace with my inner self already, so I'd be curious to see how it could help me deal with some of my ruts I get in from time to time. Alcohol definitely isn't helping

I know my posts on Hacker News are like a broken record, but have you considered talk therapy (if it’s available to you)?

“Rut” and “alcohol” are two words that set off depression alarms. Medication and therapy — or if you’re opposed to medication, just therapy — help. I know from experience.

Edit: Not to be down on psychedelics at all —- I’m optimistic about the role of psychedelics in future depression treatment. It’s just that nearly everything about dosing for depression is anecdote and more mundane tools work in a large number of cases.

Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

#73

Earlier quoted context omitted.

This study doesn't bear that out, nor have any other placebo-controlled trials. Also, I've experienced about 40 different psychoactive drugs, including both micro and megadoses of psychedelics. And my experience tracks with GP in that it does cognitively impair you. Maybe don't make blanket statements about people you disagree with, it doesn't make your argument look any stronger.

>I've experienced about 40 different psychoactive drugs That is insane How is your brain not fried

I didn't say it wasn't :)

I jest, but mostly I took reasonable precautions and stuck to things I was reasonably sure weren't harmful, or at least toxic. I've had some very bad times with the synthetic cannabinoid, though, and I don't wanna go into it other than to say: I was hella lucky not to have my brain fried. Happy to say I've gained a healthier relationship to drugs since then.

Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

#74

How does one even get contacts to consider this (in a safe manner)? One thought about this and I'd actually consider myself fairly in tune and at peace with my inner self already, so I'd be curious to see how it could help me deal with some of my ruts I get in from time to time. Alcohol definitely isn't helping

If you live in Canada, and specifically in Vancouver, there are de facto legal operating dispensaries for psilocybin [0]. If you don't live there, but live in the USA, some of said shops will ship products to USA. Now, I don't know if this hits your threshold for "safe", but seeing as the doses involved are quite low, one could argue that it would be safer than, say, starting a new (SSRI) antidepressant if you take into account long-term effects [1], side-effects, etc [2].

[0]: https://www.cbc.ca/news/canada/british-columbia/magic-mushro... [1]: https://news.ycombinator.com/item?id=29024808 [2]: https://www.nature.com/articles/s41380-022-01661-0

Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

#75

Earlier quoted context omitted.

Yeah, drugs feel great, news at 11. If psychiatry was just a matter of giving people a constant buzz, it would be solved a century ago. I'm not judging you for wanting to be high all the time, I've been there myself. But be intellectually honest and call it that, at least. Because it's not some kind of psychological panacea, and I wish people would stop implying it is. And yes, I've tried it. It made me high, but gen…

That's an uncharitable reading. OP is just sharing what works with her/him. Which is ok. From what I understood from your comment, for you it doesn't. Which is ok too, as now you know yourself a bit better. Two personal experiments with very different outcomes. There's no need for moral judgments either way.

Does "if it works for you" also go for things like aspirin, antihistamines, antihypertensives, antibiotics, etc? I've never heard anyone say "if aspirin works for you then take it, but it doesn't work for me". I've only heard this kind of thing said for things like homeopathy, astrology, accupuncture, osteopathy, and microdosing, of course. Hence, I'm very skeptical.

[Edit: OK, I've heard people say that aspirin doesn't work for them, but what they meant was that they had pains that were too strong to respond to mere aspirin.]

Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

#76

How does one even get contacts to consider this (in a safe manner)? One thought about this and I'd actually consider myself fairly in tune and at peace with my inner self already, so I'd be curious to see how it could help me deal with some of my ruts I get in from time to time. Alcohol definitely isn't helping

I'm in US, so that's all I can speak to. Psilocybin spores are legal to purchase in most states, though growing/possession are illegal. Once you have the spores, you just grow your own. Techniques(teks in the magic mushroom world) like PF Tek and Uncle Ben's Tek are pretty easy. Uncles Ben's is especially popular, because it takes out the sterilization step.

Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

#78
post #77

Do mushrooms make you write incoherent ramblings on Facebook about how you are God and how everyone else is stuck in the matrix? Because I have 3 different friends who all started doing that after dabbling in psychedelics

No. Schizophrenia does. Probably a few other things.

Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

#79
post #77

Do mushrooms make you write incoherent ramblings on Facebook about how you are God and how everyone else is stuck in the matrix? Because I have 3 different friends who all started doing that after dabbling in psychedelics

As far as I know it is a possible side effect of psychedelics indeed

Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

#80

I have been interested for quite some time to dabble with psilocybin but just haven't yet had the chance with buddies(outside of a work related traveling event) to do so. I absolutely refuse to try anything like this outside of an environment I have some level of control in or trust in the people around me(not the general public I.E: Bars, clubs, Vegas, etc). Any advice on what to avoid for a first timer from any exp…

Queue up your favorite good-mood music, or a just a tripping playlist from Spotify or similar. Music has a huge impact on trip feel for me, and I can normally adjust out of a difficult trip with a music change.

Stay in a safe place, with a trust friend that is sober(a "tripsitter"). And start low, 1.75g dosage or so.

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