Earlier quoted context omitted.
Speaking of being misled, we were pretty much promised by the Scottish nationalists that this was a once in a generation choice. Seems we voted wrong the last time so here we are again with all the uncertainty to go with it. Though right now I want the second referendum as it's probably the best way to end the uncertainty that SNP causing
I am an outsider on the topic, but wouldn't such a stark change of the political landscape as Brexit be a really valid reason to ask the question again? After all, independence before would have meant exiting the EU, while it now could mean re-entering it. Independence is ultimately the question about how a region wants to see itself in the world, and the alliances you are in are a big factor in that qestion.
You could argue that, but, the nationalists never did. Instead they said the issue would be categorically resolved by the referendum for an entire generation. Perhaps if they were a bit smarter they'd have thought ahead and caveated their promises, but they wanted to create artificial pressure that they thought would help them.
Then they lost and it was immediately revealed that they were lying. It wasn't going to be a once-in-a-lifetime vote unless they won, in which case of course, they'd never let anyone vote on the topic ever again (if you believe they'd host a "let's rejoin the UK" referendum even in 50 years you don't know the SNP).
Brexit meanwhile is not actually a stark change in political landscape. It has barely affected the lives of most people. It's not at all clear why that should make a difference when there are so many other wedge issues the SNP could also use to claim now it's all different.
Really, if they wanted to ask the question again and win the best way would be to campaign for English voters to also be given the vote. Polls show a significant number of English voters would quite like to be rid of Scotland - whilst politicians really want to keep the union together, actual voters aren't so in love with it. Scotland sometimes gets perceived comes across as more trouble than it's worth: a left wing heavily subsidy dependent one-party statelet mired in corruption and with leadership that vigorously encourages anti-English racism.