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Transfusion of brain fluid from young mice improves memory in old mice

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Re: Transfusion of brain fluid from young mice improves memory in old mice

#151

Post by meowface »

solfox wrote: post #90
meowface wrote: post #67

Earlier quoted context omitted.

I think it's the exact opposite. The day being old is no longer a disease and a path to inevitable death will be one of the greatest things to ever happen to humanity, now and forever into the future. Especially if you can retain a youthful, healthy brain and body no matter how old you are. An old tyrannical movie villain dies and a to-be old tyrannical movie villain is born. Billions of people shouldn't be sentenced…

Death is a beautiful happening that we should not fear so much. It allows growth and transmutation of stagnant ideology.

All I can say is I wholeheartedly disagree. It has some pragmatic utility in replacing stale, antiquated ideologies, but the costs vastly outweigh the benefits, and there are always future solutions that can help retain such things to a degree: e.g. you can no longer vote or run for office if you're above the age of 110, or whatever.

Re: Transfusion of brain fluid from young mice improves memory in old mice

#152

Post by mleonhard »

s1artibartfast wrote: post #137
mleonhard wrote: post #130

Earlier quoted context omitted.

Thanks for checking. Alzheimer Management By Albumin Replacement (AMBAR) treatment has shown efficacy in slowing the progression of moderate & advanced stages disease [0, 1]. [0] https://doi.org/10.1080/14737175.2021.1960823 [1] https://doi.org/10.1002/alz.12137

Yeah, is totally absurd that given the health care and social cost of of Alzheimer's we're not taking Broad shotgun approach to investigating potential remedies. There are a lot of treatments that's worth dumping several million dollars in even if they are low probability of having durable effects.

It doesn't happen because of the structure of society. Capitalism efficiently allocates capital, but does not maximize citizen quality-of-life.

Re: Transfusion of brain fluid from young mice improves memory in old mice

#153

Post by s1artibartfast »

mleonhard wrote: post #152
s1artibartfast wrote: post #137

Earlier quoted context omitted.

Yeah, is totally absurd that given the health care and social cost of of Alzheimer's we're not taking Broad shotgun approach to investigating potential remedies. There are a lot of treatments that's worth dumping several million dollars in even if they are low probability of having durable effects.

It doesn't happen because of the structure of society. Capitalism efficiently allocates capital, but does not maximize citizen quality-of-life.

Either that or bureaucratic NIH grant grant approvers have no balls.

Re: Transfusion of brain fluid from young mice improves memory in old mice

#154

Post by mleonhard »

s1artibartfast wrote: post #153
mleonhard wrote: post #152

Earlier quoted context omitted.

It doesn't happen because of the structure of society. Capitalism efficiently allocates capital, but does not maximize citizen quality-of-life.

Either that or bureaucratic NIH grant grant approvers have no balls.

Do you have any evidence to accuse NIH of fault, or is your comment pure speculation?

Re: Transfusion of brain fluid from young mice improves memory in old mice

#155

Post by monkeycantype »

google234123 wrote: post #131
monkeycantype wrote: post #129

Imagine if it turns out that 30 mls a month of blood loss for a few decades is the reason women live longer than man

I doubt it's so simple.

So do I but the idea is amusing

Re: Transfusion of brain fluid from young mice improves memory in old mice

#156

Post by s1artibartfast »

mleonhard wrote: post #154
s1artibartfast wrote: post #153

Earlier quoted context omitted.

Either that or bureaucratic NIH grant grant approvers have no balls.

Do you have any evidence to accuse NIH of fault, or is your comment pure speculation?

I have been turned down for a half dozen grants in AD research I think could impact millions of lives, and see them funding bs and no impact projects.

I obviously have biases and an axe to grind, but these are my opinions.

Re: Transfusion of brain fluid from young mice improves memory in old mice

#157

Post by piyh »

throwuxiytayq wrote: post #140
piyh wrote: post #125

Earlier quoted context omitted.

Donate blood and a man can bleed for a day. Donate marrow and a man can bleed for a lifetime.

A while ago I read about marrow donation. Turns out I had all kinds of misconceptions (thought it waa invasive and painful). I'll definitely try to donate when I get my health back in order.

It was not enjoyable, but I'd do it again. The emotional side of it was way more difficult than the physical side. I'd recommend getting benzos for the actual donation day.

Re: Transfusion of brain fluid from young mice improves memory in old mice

#158

Post by mleonhard »

s1artibartfast wrote: post #156
mleonhard wrote: post #154

Earlier quoted context omitted.

Do you have any evidence to accuse NIH of fault, or is your comment pure speculation?

I have been turned down for a half dozen grants in AD research I think could impact millions of lives, and see them funding bs and no impact projects. I obviously have biases and an axe to grind, but these are my opinions.

Thanks for explaining. How about publishing those rejected grant proposals?
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