121–130 of 158 posts
If you're interested in aging topics, he did a recent debate with Dr. Aubrey de Grey: https://www.youtube.com/watch?v=MJIvp_J-kzM
I wonder how long until this is a thing some people do; like the blood transfusions from younger/healthy people.
Russell manages to give a laugh at even the most disturbing topics. Here is is his show about the huge industry of blood extraction. https://youtu.be/82pOL361zUk
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Could it be this simple? Shit just builds up in the blood that the liver and kidneys and stuff are not 100% efficient at removing? So you just need to... get rid of it or dilute it? I mean that can't possibly be a full solution but could a major "win" on life span or at least health span be as simple as some kind of dialysis session? Could this also be a hidden mechanism involved in some of that hyperbaric oxygen cha…
It is that simple to some extent, recycling and resource control is a major factor in aging. Targets: Autophagy, senolytics (don't take senolytics), lysosomes, metabolic rate, proteasome,chaperone proteins,amyloids,Lipofuscin. The best example of stuff literally accumulating macroscopically in your body (besides the impressive images of Lipofuscin) is metals accumulation in bones. They cause a lot of damage, includin…
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I've actually been regularly donating for years for that very reason. I figured my body will just create new blood to fill in the gap and much like changing power steering fluid, after enough time it's mostly new stuff.
But your blood is created by cells dividing and they cannot do so unlimited. Your DNA shortens and you run out of room for mistakes proteins make while translating it.
Haven't similar things been observed with blood transfusions of young blood into the elderly, which was then found to actually be unnecessary - even just diluting the blood with something neutral and clean produced similar results. "The solution to pollution is dilution"
All the more reason to donate blood.
These kinds of articles give me the creeps. As interesting as the science is, I imagine this also encourages a bunch of silicon valley millionaires and billionaires to essentially become vampires.
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I think it's the exact opposite. The day being old is no longer a disease and a path to inevitable death will be one of the greatest things to ever happen to humanity, now and forever into the future. Especially if you can retain a youthful, healthy brain and body no matter how old you are. An old tyrannical movie villain dies and a to-be old tyrannical movie villain is born. Billions of people shouldn't be sentenced…
Pretty sure the possible world being lamented in the GP comment is not "everyone gets to live forever and stay healthy and youthful" but instead "there exist expensive, parasitic procedures which will allow some rich people to have drastically extended lifespans."
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I've actually been regularly donating for years for that very reason. I figured my body will just create new blood to fill in the gap and much like changing power steering fluid, after enough time it's mostly new stuff.
But your blood is created by cells dividing and they cannot do so unlimited. Your DNA shortens and you run out of room for mistakes proteins make while translating it.
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Can you share any more information about the medical device that showed efficacy against Alzheimers in the 200-patient trial?
This is one that I thought was compelling.[1] The trial ultimately failed but if you read the results the post-hoc analysis, it showed promise in mild and moderate subgroups of the ITT population. Most drugs today don't even target mild AD, but go after pre-symptomatic patients. There was also benefit across most measures, but just not of statistical significance. The trial had some major problems with appropriate co…