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Transfusion of brain fluid from young mice improves memory in old mice
71–80 of 158 posts
Re: Transfusion of brain fluid from young mice improves memory in old mice
#72Death is the ultimate equalizer. We take solace in the fact that no matter how rich, brutal, tyrannical, comically-villainous one is, death will surely come for us all. The day old-gizzards figure out how to sip on young-people juice and live forever, we are truly screwed.
Death is just a horrible thing that happens. The facts that it come equally for both heroes and villains doesn't change that.
Re: Transfusion of brain fluid from young mice improves memory in old mice
#73Haven't similar things been observed with blood transfusions of young blood into the elderly, which was then found to actually be unnecessary - even just diluting the blood with something neutral and clean produced similar results. "The solution to pollution is dilution"
Could it be this simple? Shit just builds up in the blood that the liver and kidneys and stuff are not 100% efficient at removing? So you just need to... get rid of it or dilute it? I mean that can't possibly be a full solution but could a major "win" on life span or at least health span be as simple as some kind of dialysis session? Could this also be a hidden mechanism involved in some of that hyperbaric oxygen cha…
It is that simple to some extent, recycling and resource control is a major factor in aging.
Targets:
Autophagy, senolytics (don't take senolytics), lysosomes, metabolic rate, proteasome,chaperone proteins,amyloids,Lipofuscin.
The best example of stuff literally accumulating macroscopically in your body (besides the impressive images of Lipofuscin) is metals accumulation in bones. They cause a lot of damage, including a major cause of neurodegeneration. They can be removed via chelators.
BTW I would avoid hyperbaric at all cost even if hornesis is a thing. Oxygen is literally the reason we are all slowly dying, we oxidize and implode. But don't refrain from breathing, hypoxia incurs more damage. If you want to prevent oxidation you need Skq1.
Re: Transfusion of brain fluid from young mice improves memory in old mice
#74Earlier quoted context omitted.
My lay person assumption is it's more complicated than that, just knowing how the body is always conserving resources and adapting to changing conditions. I'd expect the body's natural mechanisms responsible for this to wind down operations the more you intervened on its behalf. It's obviously the right choice in the elderly/ill, but for a healthy young person maybe it's better to exercise/strengthen the body's natur…
Exercise and fasting are two known and proven ways to clean up the tissues of the body, yes.
And most importantly, sleep and the glymphatic system.
There are many substances that promote Autophagy though.
Re: Transfusion of brain fluid from young mice improves memory in old mice
#75Earlier quoted context omitted.
Exercise and fasting are two known and proven ways to clean up the tissues of the body, yes.
And most importantly, sleep and the glymphatic system. There are many substances that promote Autophagy though.
For the brain, yes.
Re: Transfusion of brain fluid from young mice improves memory in old mice
#76Death is the ultimate equalizer. We take solace in the fact that no matter how rich, brutal, tyrannical, comically-villainous one is, death will surely come for us all. The day old-gizzards figure out how to sip on young-people juice and live forever, we are truly screwed.
I think it's the exact opposite. The day being old is no longer a disease and a path to inevitable death will be one of the greatest things to ever happen to humanity, now and forever into the future. Especially if you can retain a youthful, healthy brain and body no matter how old you are. An old tyrannical movie villain dies and a to-be old tyrannical movie villain is born. Billions of people shouldn't be sentenced…
Pretty sure the possible world being lamented in the GP comment is not "everyone gets to live forever and stay healthy and youthful" but instead "there exist expensive, parasitic procedures which will allow some rich people to have drastically extended lifespans."
Re: Transfusion of brain fluid from young mice improves memory in old mice
#77Death is the ultimate equalizer. We take solace in the fact that no matter how rich, brutal, tyrannical, comically-villainous one is, death will surely come for us all. The day old-gizzards figure out how to sip on young-people juice and live forever, we are truly screwed.
Death is just a horrible thing that happens. The facts that it come equally for both heroes and villains doesn't change that.
Death is just a thing that happens. Whether it is horrible, sad, a relief or a reason to celebrate depends on whom you ask about whose death at which point in time.
The suicide of Hitler certainly was a horrible tragedy to his close family and those who believed into him — for many others it was a reason to celebrate. Similarily death of a young family member can be traumatic to the max, while the death of grandmother which everybody (including herself) already accepted and comes after a live well lived can be even have a certain beauty to it.
Death is not that simple.
Re: Transfusion of brain fluid from young mice improves memory in old mice
#78Death is the ultimate equalizer. We take solace in the fact that no matter how rich, brutal, tyrannical, comically-villainous one is, death will surely come for us all. The day old-gizzards figure out how to sip on young-people juice and live forever, we are truly screwed.
I think it's the exact opposite. The day being old is no longer a disease and a path to inevitable death will be one of the greatest things to ever happen to humanity, now and forever into the future. Especially if you can retain a youthful, healthy brain and body no matter how old you are. An old tyrannical movie villain dies and a to-be old tyrannical movie villain is born. Billions of people shouldn't be sentenced…
An old tyrannical movie villain dies and a to-be old tyrannical movie villain is born. Billions of people shouldn't be sentenced to death just because the world might be a bit better off if a few people weren't immortal.
Tyrants aren't even forever even if they never die of old age. After all, tyrants can meet their end through constantly replacing their followers with yes-men to the point of becoming increasingly detached from reality. This may prevent them from noticing certain features of reality such as military incompetence of their force.
Re: Transfusion of brain fluid from young mice improves memory in old mice
#79Science has proved once again that we can cure MICE of just about anything. Maybe if we would let them experiment on us we get better human results.
Re: Transfusion of brain fluid from young mice improves memory in old mice
#80Death is the ultimate equalizer. We take solace in the fact that no matter how rich, brutal, tyrannical, comically-villainous one is, death will surely come for us all. The day old-gizzards figure out how to sip on young-people juice and live forever, we are truly screwed.
For me, death is not the main problem, but the long, drawn out period of slowly coming apart definitely is. I would very much prefer not to spend last 15 years of my life crippled from multiple degenerative diseases of old age.
Most of the longevity research is trying to stretch healthspan. Stretching lifespan as such is a nice side effect.
We aren't likely to live forever anyway.