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Transfusion of brain fluid from young mice improves memory in old mice

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Re: Transfusion of brain fluid from young mice improves memory in old mice

#141

Post by SemanticStrengh »

ErikAugust wrote: post #123
SemanticStrengh wrote: post #73

Earlier quoted context omitted.

It is that simple to some extent, recycling and resource control is a major factor in aging. Targets: Autophagy, senolytics (don't take senolytics), lysosomes, metabolic rate, proteasome,chaperone proteins,amyloids,Lipofuscin. The best example of stuff literally accumulating macroscopically in your body (besides the impressive images of Lipofuscin) is metals accumulation in bones. They cause a lot of damage, includin…

Where does one find Skq1?

https://mitolab.com/product/vismotech-skq1-bromide-solution-... You should always coadminister (take at the same time or a bit before) NAC (600mg+) SkQ1 is a revolutionary geroprotector,it significantly slow down the aging process. Unfortunately it can (proportionately with the dose) reduce mitochondria bioenergetics via a paradoxal, local, pro-oxidation. Studies have found NAC mostly prevent this paradoxal oxidative side effect.

It was probably in this paper https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422527/

Google Skq1 on pubmed to see how great it is

Re: Transfusion of brain fluid from young mice improves memory in old mice

#142

Post by throwntoday »

allendoerfer wrote: post #120
throwntoday wrote: post #118

Earlier quoted context omitted.

I've actually been regularly donating for years for that very reason. I figured my body will just create new blood to fill in the gap and much like changing power steering fluid, after enough time it's mostly new stuff.

But your blood is created by cells dividing and they cannot do so unlimited. Your DNA shortens and you run out of room for mistakes proteins make while translating it.

I only need to live long enough for one form of eternal life to transpire. Cyborg body, brain transplant to a clone, reversal of aging. I don't mind helping out others while I wait :-)

Re: Transfusion of brain fluid from young mice improves memory in old mice

#143

Post by ninesnines »

SemanticStrengh wrote: post #66
s1artibartfast wrote: post #47

Earlier quoted context omitted.

Modifying CSF turnover is not particularly novel, but I do think it is generally overlooked. CSF production cycling is greatly reduced in the elderly and and there are a lot of connections to memory diseases such as alzheimers. A few medical device startups have attacked the problem with promising results. Unfortunately, VC and national funding orgs aren't particularly interested in device based solutions because pil…

I remember seeing a drug/substance that potentiated the glymphatic system filtration but I just can't find it again, it's been a year..

sorry! maybe it's just my thoughts on the matter that have changed. i understand that you can have drugs move through the glymphatic system, but maybe i was just unaware that you can move a whole host of other cell proliferation factors through the glymphatic system also!

Re: Transfusion of brain fluid from young mice improves memory in old mice

#144

Post by Llamamoe »

vasco wrote: post #40
Llamamoe wrote: post #33

Earlier quoted context omitted.

Not quite the same, but there exists a nootrooic called Cerebrolysin which is made from enzymatically treated pig brain peptides, including all sorts of brain growth factors.

I wonder if taking something with brain growth factors makes you more or less likely to suffer from more serious consequences if you have brain trauma. ie Are you more or less likely to have a serious concussion after hitting your head.

Generally speaking, brain growth factors are protective against and regenerative of brain damage/atrophy. You could call them pro-neuronal-function factors.

Re: Transfusion of brain fluid from young mice improves memory in old mice

#145

Post by filoeleven »

lambdasquirrel wrote: post #135
davesque wrote: post #44

These kinds of articles give me the creeps. As interesting as the science is, I imagine this also encourages a bunch of silicon valley millionaires and billionaires to essentially become vampires.

I don't know why it needs to start with Silicon Valley necessarily. Because we're a bunch of socially-awkward people? We just saw the Jeffrey Epstein thing unfold, and who-knows what well-connected old-money/old-power folks were serviced by him and Ghislaine Maxwell. If they could extend their life and get their pickings of young girls, you bet they'd do it. This old-eating-the-young thing has been going on for time…

> I don't know why it needs to start with Silicon Valley necessarily. Because we're a bunch of socially-awkward people?

No, It’s because Peter Thiel was (perhaps still is) reportedly interested in it, and that was a big enough story to be eventually lampooned by the comedy show Silicon Valley.

Re: Transfusion of brain fluid from young mice improves memory in old mice

#147

Post by SemanticStrengh »

ninesnines wrote: post #143
SemanticStrengh wrote: post #66

Earlier quoted context omitted.

I remember seeing a drug/substance that potentiated the glymphatic system filtration but I just can't find it again, it's been a year..

sorry! maybe it's just my thoughts on the matter that have changed. i understand that you can have drugs move through the glymphatic system, but maybe i was just unaware that you can move a whole host of other cell proliferation factors through the glymphatic system also!

To be clear I was talking about a drug that increase the fluid movement rate/duration/frequency of the glymphatic filtering, which allow to improve the quantity of cleaning. If you're talking about the effect of the glymphatic system on the repartition of Neurotrophics, I have no idea :)

Re: Transfusion of brain fluid from young mice improves memory in old mice

#148

Post by swader999 »

SemanticStrengh wrote: post #73
api wrote: post #15

Earlier quoted context omitted.

Could it be this simple? Shit just builds up in the blood that the liver and kidneys and stuff are not 100% efficient at removing? So you just need to... get rid of it or dilute it? I mean that can't possibly be a full solution but could a major "win" on life span or at least health span be as simple as some kind of dialysis session? Could this also be a hidden mechanism involved in some of that hyperbaric oxygen cha…

It is that simple to some extent, recycling and resource control is a major factor in aging. Targets: Autophagy, senolytics (don't take senolytics), lysosomes, metabolic rate, proteasome,chaperone proteins,amyloids,Lipofuscin. The best example of stuff literally accumulating macroscopically in your body (besides the impressive images of Lipofuscin) is metals accumulation in bones. They cause a lot of damage, includin…

Thoughts on fisetin?

Re: Transfusion of brain fluid from young mice improves memory in old mice

#149

Post by philjohn »

lambdasquirrel wrote: post #135
davesque wrote: post #44

These kinds of articles give me the creeps. As interesting as the science is, I imagine this also encourages a bunch of silicon valley millionaires and billionaires to essentially become vampires.

I don't know why it needs to start with Silicon Valley necessarily. Because we're a bunch of socially-awkward people? We just saw the Jeffrey Epstein thing unfold, and who-knows what well-connected old-money/old-power folks were serviced by him and Ghislaine Maxwell. If they could extend their life and get their pickings of young girls, you bet they'd do it. This old-eating-the-young thing has been going on for time…

Also the Blood Libel against Jewish people, of which QAnon is just the latest incarnation.

Re: Transfusion of brain fluid from young mice improves memory in old mice

#150

Post by s1artibartfast »

SemanticStrengh wrote: post #147
ninesnines wrote: post #143

Earlier quoted context omitted.

sorry! maybe it's just my thoughts on the matter that have changed. i understand that you can have drugs move through the glymphatic system, but maybe i was just unaware that you can move a whole host of other cell proliferation factors through the glymphatic system also!

To be clear I was talking about a drug that increase the fluid movement rate/duration/frequency of the glymphatic filtering, which allow to improve the quantity of cleaning. If you're talking about the effect of the glymphatic system on the repartition of Neurotrophics, I have no idea :)

There's a fair bit of literature suggesting that there's more to it than the production rate. Metabolite delivery and removal also depends on the dynamic pressure and frequency response of the system. That is to say, to get the appropriate pulsatile flow the brain can't be too rigid or too flaccid
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