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Treatment for Tinnitus with Stimulation of Auditory and Non-Auditory Nerves

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Re: Treatment for Tinnitus with Stimulation of Auditory and Non-Auditory Nerves

#101
post #54

Earlier quoted context omitted.

Yes, it really needs to be that loud. Above a threshold (about 90-100 decibels (dba or dbc - can't recall)) the vestibular system in the inner ear (the balancy bit) is stimulated, which ?induces dancing? and ?feels good? ... https://sci-hub.se/https://asa.scitation.org/doi/pdf/10.1121...

Meanwhile, in other news .... noise-induced vestibular damage.

Yes, it really needs to be that damaged.

Well, it technically doesn't need the damage, some people just like it.

Re: Treatment for Tinnitus with Stimulation of Auditory and Non-Auditory Nerves

#102
post #46

Not sure why I click into comment threads on HN about tinnitus, hoping for positive news or anecdotes, but it’s almost always the opposite. So I’ll share my positive anecdote. I’ve dealt with it for over 10 years, and while I can’t imagine how happy I would be to find an effective treatment, I’ve learned to cope, and do what I can to protect hearing going forward. And once you realize you can cope with it, it makes f…

Just to say that in advance, although I'm a CS guy, I also have quite a bit of background in life sciences, so what I'm saying is not from someone naive about bio-chem or physiology. I got rid of my tinnitus - which was not even the goal, it was not too bad compared to all the many other issues I increasingly had and which forced my hand - after removing the remaining amalgam fillings in my teeth and starting chelati…

> on what exactly do you downvote this report of my clinical experience?

Most of the things you are complaining of are symptoms that many, many people have at one time or another. I have had most of them at one time or another.

So you are not particularly special, and should perhaps relax - a lot of these things can be brought on by anxiety.

Re: Treatment for Tinnitus with Stimulation of Auditory and Non-Auditory Nerves

#103

Serious question I’ve avoided googling: Does anyone else have tinnitus in specific locations? For me, I swear I am constantly hearing high-pitched screeching, but only in apartments or offices. If I’m outside it goes away — even if it’s very quiet.

Yes. For me, my dining room chandelier lights (or the dimmer switch) are excruciating to me. No one else in my family can "hear the lights"...

Re: Treatment for Tinnitus with Stimulation of Auditory and Non-Auditory Nerves

#104

Not sure why I click into comment threads on HN about tinnitus, hoping for positive news or anecdotes, but it’s almost always the opposite. So I’ll share my positive anecdote. I’ve dealt with it for over 10 years, and while I can’t imagine how happy I would be to find an effective treatment, I’ve learned to cope, and do what I can to protect hearing going forward. And once you realize you can cope with it, it makes f…

Have you found what causes the bad days? I suffer from this too and haven't been able to figure out why it's worse some days than others. It seems random, but I wonder if there's a causal factor I'm just not noticing.

Seems like possible triggers include certain noise levels/frequencies, stress and/or blood pressure, and fatigue.

But not really figuring out a rhyme or reason. Fortunately at its worst it never seems to last more than a few hours, maybe a day max.

But as many have stated, your mind just moving to other things helps even when it’s bad. Figuring out that it’s possible to cope is the biggest help of coping and getting through the tougher hours/days.

Re: Treatment for Tinnitus with Stimulation of Auditory and Non-Auditory Nerves

#105
post #26

Earlier quoted context omitted.

> remember that noise-cancelling is NOT hearing protection I fell for this one as well. I wouldn't be to surprised if noise-cancelling could actually cause tinnitus, or make an onset of it worse (though I haven nothing but biased anecdata to argue the opinion).

That is interesting, I was using noise cancelling headphones a lot when mine came started. Of course the morning it came on I was also recovering from being riotously drunk the night before, and I'm more inclined to believe something about that triggered it

Long term sufferer here.. One specific metal concert 15 years ago did me in (unfortunately). I too found that noise cancelling headphones actually flared up my tinnitus more; and resorted to selling my headphones.

Re: Treatment for Tinnitus with Stimulation of Auditory and Non-Auditory Nerves

#106
post #99

Earlier quoted context omitted.

intermitent fasting can reduce base metabolic rate which can in theory downregulate glut. moreover diet alter many signaling pathways, including reduced oxidative stress, which are beneficial to some extent for tinnitus.

I've been IF for several years now (for whatever good it's done me!), sometimes very strictly and sometimes casually, and I've noticed no correlation whatsoever to my tinnitus. I do buy that anything that really reduces inflammation or anything like that could help, because my tinnitus is definitely correlated to ear congestion and sinus inflammation (but it's always there at some level no matter what). Basically, my…

Not al tinnitus is caused by the same process, and some nerve damage might be permanent.

My tinnitus was not caused by loud sounds and I have had it since I was a kid. My body is not "efficient" in dealing with glutamate, which is why I need klonopin and also why some people have seizures.

https://pubmed.ncbi.nlm.nih.gov/7970002/

I wish people will finally understand that we are not all the same genetically and it is a big deal.

Intermittent fasting will lower glutamate levels, as will getting calories from fats. This is why they give this diet to children withs seizures.

https://onlinelibrary.wiley.com/doi/abs/10.1002/jnr.20831

https://www.sciencedirect.com/science/article/abs/pii/S05315...

Re: Treatment for Tinnitus with Stimulation of Auditory and Non-Auditory Nerves

#107
post #90

Earlier quoted context omitted.

As I understand it, diet has not all that much to do with glutamate levels. Your body very rapidly metabolizes it (they do studies where they stuff people full of glutamate while repeatedly checking their blood, and it takes a nauseating amount to see a plasma glutamate spike), and the blood-brain barrier is impermeable to glutamate.

intermitent fasting can reduce base metabolic rate which can in theory downregulate glut. moreover diet alter many signaling pathways, including reduced oxidative stress, which are beneficial to some extent for tinnitus.

intermittent fasting lowers glutamate because it changes where the TCA cycle gets its energy, not because it reduces the metabolic rate.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1940242/figure/...

Re: Treatment for Tinnitus with Stimulation of Auditory and Non-Auditory Nerves

#108

Earlier quoted context omitted.

Tofisopam is a type of benzodiazepine, yes? Benzodiazepines are depressants that enhance the effect of the GABA, and the literature suggests that tofisopam does not act on the GABA-A receptor but it does enhance the binding of other benzodiazepines to their binding sites. Any increase in GABA will counteract the excitatory transmission of Glutamate. That is all that matters. But I know klonopin can eliminate my Tinni…

> Any increase in GABA will counteract the excitatory transmission of Glutamate. That is all that matters. No that is not all that matters. The main effect of tofizopam is unrelated to GABAergy, the fact it indirectly modulate GABA-A and potentiate benzos is a plus but its main effect come from atypical PDE inhibition. Look if klonopin is viable for you and solve your tinnitus that's great to hear. But for many peopl…

> The main effect of tofizopam is unrelated to GABAergy

It's a antagonist of the AMPA receptor. I am not saying it has anything to do with GABA-A but it enhances the action of GABA.

https://www.nature.com/articles/nn0600_551

>By taking a classical benzo like klonopin you increase your GABA-A level which inhibit the overload of excitation (GLUT).

No, Klonopin does not increase GABA, it attaches to the GABA-A receptor to allow more chloride into the cell. It only enhances the activity go GABA.

https://en.wikipedia.org/wiki/Clonazepam#Pharmacology

Re: Treatment for Tinnitus with Stimulation of Auditory and Non-Auditory Nerves

#109

I recently had a bout of tinnitus (took me a while to identify the high pitched whine!) which was cleared up by sound generators on https://mynoise.net/ ... I guess that qualifies as stimulation of auditory nerves. YMMV but always worth a try!

Thanks, I'll give it a try. I got tinnitus from COVID.

Re: Treatment for Tinnitus with Stimulation of Auditory and Non-Auditory Nerves

#110
post #46

Earlier quoted context omitted.

Just to say that in advance, although I'm a CS guy, I also have quite a bit of background in life sciences, so what I'm saying is not from someone naive about bio-chem or physiology. I got rid of my tinnitus - which was not even the goal, it was not too bad compared to all the many other issues I increasingly had and which forced my hand - after removing the remaining amalgam fillings in my teeth and starting chelati…

> on what exactly do you downvote this report of my clinical experience? Most of the things you are complaining of are symptoms that many, many people have at one time or another. I have had most of them at one time or another. So you are not particularly special, and should perhaps relax - a lot of these things can be brought on by anxiety.

I am well aware of that. But why do you think I'm stupid? I even said I have a good background, even as far as statistics and reading medical papers and even a few courses on setting up and evaluating clinical trials.

I never had "anxiety". I never was stressed by life or my circumstances. I lived very comfortably.

I also did mention that I was at a university clinic and had a doctor, who even had actually suspected that I had more and did look for other causes. Do you think that doctor, who was a researcher too, was not capable? I also mentioned he did not have a financial incentive - when I was still searching for a cause after it had escalated and nobody could help I had plenty of doctors trying to sell me useless stuff. I'm not even mad, they did so after doing what they could with their training, if I had a specific problem within their field of expertise I would still go to each of them, just now better knowing how to use them instead of expecting a solution to all problems (just an aside, but we know financial incentives matter - plenty of reports and studies about useless overtreatment).

All those things I mentioned were stable and increasing for over two decades. And then they went away quickly after chelation therapy. They were not even on the radar!

And you seriously propose I suffered from "head stuff"???

Also, doctors look at symptoms as a whole. Sure you can ignore everything I wrote (and even more that only my doctor and me know) and try to refute every single system individually by claiming I must have about a hundred different conditions, one for every little issue. Or, you can accept that there was only one problem to begin with that caused them all.

What exactly is so outrageous about accepting heavy metals as a cause? "There is no safe level of lead" is official mantra, and I found a paper for training health workers on an NIH website saying mercury is an order of magnitude worse. So where exactly is it so unthinkable that that stuff actually does cause problems in the real world, and not just in theoretical medical papers?

After about a year both my doctor and I on the same appointment wanted (and di) to say to one another the same thing. I wanted to ask, because I was aware of the lab test values over time, and he said it before I could ask, that we had reached the end of treatment covered by medical science and the available studies. But he agreed I could continue under his now more passive and more observing guidance if I felt it still helped. It did so for years, and I had signs, not just symptoms, associated with continued use of chelators. That included reactions from within my jaw after chelation and a lot of other stuff, visible. If all of that was "psychological", then there really is no need for doctors any more and they can all retrain as psychologists because nothing is real.

But you know what? It actually really was in my head! mercury is a neurotoxin, so yes, there was definitely an impact. Brain is chemistry though! I'll never understand this "it's just psychological" mindset, which is the real unscientific esoteric quasi-religious stuff as far as I'm concerned.

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