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Soybean oil affects hypothalamus, causes genetic changes in mice: study (2020)

universityofcalifornia.edu

341–350 of 464 posts

Re: Soybean oil affects hypothalamus, causes genetic changes in mice: study (2020)

#341

Earlier quoted context omitted.

the rates of linoleic acid in eggs, large, chicken, beef, pork have all changed drastically in the last 100 years because what we feed the animals has changed drastically. a grass fed cow has a lower omega6 profile than one in a factory farm. farmers have gotten tricky with it, raising "grass fed cows" but then for a couple months before slaughter, fattening them up with industry "feed". So now when you're at the sto…

Suggestions on how I can get enough complete protein in such a diet? I am open to reducing meat for health if this is a factor but eat about 150 grams complete protein every day and this is hard to replace from vegetarian. The few vegetarian dishes I see with significant protein are often not nearly as good as yogurt, meat, eggs or just stuff with whey protein in it. I can't see much with comparable protein to calori…

I'm a little confused, you write "vegetarian" but did you mean "vegan"?

"The few vegetarian dishes ... are often not nearly as good as yogurt, meat, eggs, or [...] whey protein"

Yogurt, eggs and whey protein are vegetarian (but not vegan). Vegetarian is extremely easy (I eat 95% vegetarian because it's cheaper and easier), vegan is very difficult and requires significant sacrifices.

Or maybe I misunderstood your sentence in some way.

I don't mean to be pedantic, but it seems to me that the discussion is going to be difficult if vegan and vegetarian are getting mixed up.

Re: Soybean oil affects hypothalamus, causes genetic changes in mice: study (2020)

#342

Earlier quoted context omitted.

>which oils would you use for frying and baking? Grapeseed oil is my go to. It's fairly neutral in flavor (slight nuttiness), has high smoke point, and is one that is a source of Vitamin E. For frying and then roasting, I use avocado oil, but keep in mind that many avocado oil bought on the shelves are already oxidized or rancid. There's a handful of brands that tested to be pure, one being Chosen Foods (that I use).…

> one that is a source of Vitamin E. AFAIK the high temperature of frying oil destroys the vitamins it may have

Vitamin E is surprisingly stable in oil compared to other vitamins (like A).

Unless you're commercially deep frying with the same oil over several days, there's minimal vitamin E loss from frying.

Re: Soybean oil affects hypothalamus, causes genetic changes in mice: study (2020)

#343
post #317

Earlier quoted context omitted.

There are some interesting coincidences that make me think that the torpor hypothesis might be worth exploring: - Basal metabolic rates in present-day Americans are substantially lower than they were in the past ( http://webcache.googleusercontent.com/search?q=cache:nqBxKGn... -- Yes, the link is from the aforementioned blog, but you can check the citations). - Mean body temperatures today are lower than in the past…

Can’t all these things also be explained by our increasingly sedentary lifestyle?

I kind of wonder how much of a role climate control has to play as well. Surely must have a role alongside straightforward inactivity.. until pretty recently, people would burn a lot of calories just regulating body temperature indoors. People with outdoor jobs/lifestyles obviously still do.

Re: Soybean oil affects hypothalamus, causes genetic changes in mice: study (2020)

#344
post #304

Earlier quoted context omitted.

I somewhat agree that the fear of linloeic acid doesn't always match facts. I do tend to avoid seed oils as they are relatively new and their health effects are rather suspect. However, in this case, the eggs and lard that existed in the human diet for a long time, are not the same. The chickens and pigs are eating a different diet and this does effect the composition of the fatty acids present in the flesh/eggs.

>I do tend to avoid seed oils as they are relatively new compared to what? various foods contain oil (eg. peanuts, cashews, soybeans, sunflower seeds). Are they different, or "suspect" as well?

All of these are extremely seasonal, and relatively rare, in terms of total caloric intake in an archaic diet.

Re: Soybean oil affects hypothalamus, causes genetic changes in mice: study (2020)

#345
post #137

> The same UC Riverside research team found in 2015 that soybean oil induces obesity, diabetes, insulin resistance, and fatty liver in mice. Then in a 2017 study, the same group learned that if soybean oil is engineered to be low in linoleic acid, it induces less obesity and insulin resistance. > “The hypothalamus regulates body weight via your metabolism, maintains body temperature, is critical for reproduction and…

Fixating on lineolic acid is kind of hard when basically all high-heat vegetable oils contain a lot of it. If lineolic acid is the problem then basically every unsaturated cooking oil other than olive oil is now unusable. Maybe canola, depending on how much lineolic acid is safe.

> Fixating on lineolic acid is kind of hard

There have been many instances, throughout history, where something that had massive adoption by our society has turned out to be bad. Lead being a relatively recent example. All the plastics (BPA, BPA free "safe" plastics, phthalates, etc) probably being the current/next.

Re: Soybean oil affects hypothalamus, causes genetic changes in mice: study (2020)

#346

Earlier quoted context omitted.

>which oils would you use for frying and baking? Grapeseed oil is my go to. It's fairly neutral in flavor (slight nuttiness), has high smoke point, and is one that is a source of Vitamin E. For frying and then roasting, I use avocado oil, but keep in mind that many avocado oil bought on the shelves are already oxidized or rancid. There's a handful of brands that tested to be pure, one being Chosen Foods (that I use).…

FWIW grapeseed oil is the absolute worst you could use if PUFAs are bad. It's >80% PUFA, higher than any other. Of course that's based on two suppositions: 1) that the reason soybean oil is bad in this study is its PUFA content, and 2) that it's also bad for humans, not just mice.

The PUFA in grapeseed oil is linolenic acid (~75%), which this specific study ruled out as the cause of the genetic expression changes observed in high-fat diets with soybean oil.

FTA:

>One additional note on this study — the research team has not yet isolated which chemicals in the oil are responsible for the changes they found in the hypothalamus. But they have ruled out two candidates. It is not linoleic acid, since the modified oil also produced genetic disruptions; nor is it stigmasterol, a cholesterol-like chemical found naturally in soybean oil.

Re: Soybean oil affects hypothalamus, causes genetic changes in mice: study (2020)

#347

It's nice to see the anti seed oil discourse ramping up lately, but I'm sort of pessimistic about this. Like what is the endgame, exactly? Seed oils are in basically everything. Trying to avoid them is like trying to avoid endocrine disruptors by not touching plastic or eating anything that has touched plastic. It's sort of an absurd thing to even attempt, it would drive you insane.

If you cook your own food, it is easy to avoid. Simply don't buy them. Use tallow, ghee, butter, coconut oilt. Note that this simple method of making what you eat will mitigate exposure to endocrine disrupting plastics too.

Coconut is a seed.

Re: Soybean oil affects hypothalamus, causes genetic changes in mice: study (2020)

#348

Earlier quoted context omitted.

the rates of linoleic acid in eggs, large, chicken, beef, pork have all changed drastically in the last 100 years because what we feed the animals has changed drastically. a grass fed cow has a lower omega6 profile than one in a factory farm. farmers have gotten tricky with it, raising "grass fed cows" but then for a couple months before slaughter, fattening them up with industry "feed". So now when you're at the sto…

Suggestions on how I can get enough complete protein in such a diet? I am open to reducing meat for health if this is a factor but eat about 150 grams complete protein every day and this is hard to replace from vegetarian. The few vegetarian dishes I see with significant protein are often not nearly as good as yogurt, meat, eggs or just stuff with whey protein in it. I can't see much with comparable protein to calori…

There's 2 ways to look at protein.

There's a life-span way and a health-span way. Do you want to live longer? or do you want to feel and potentially look better? When it comes to protein, these two things seem to be at odds with one another.

High protein is correlated with shorter lifespans.

- https://www.nih.gov/news-events/nih-research-matters/protein... - https://www.youtube.com/watch?v=yC-ej7HbPWg

You'll notice the first link shows higher lifespan when protein intake is increased after a certain age (65). it's assumed this is largely due to the number of deaths from injuries (falls) and complications from injuries that happen to the elderly and that muscle mass at this stage is vital.

But protein tends to active mTor. You want that to not be activated and you want IGF-1 to be low. These are correlated with longer lifespan.

- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611156/ - https://www.nia.nih.gov/news/understanding-mtor-pathway-and-... - https://pubmed.ncbi.nlm.nih.gov/31316753/ - https://pubmed.ncbi.nlm.nih.gov/15501691/

And it looks like studies in humans and animal models seem to reflect correlative data for "Blue Zone diets" (more or less). ( https://www.bluezones.com/2020/07/blue-zones-diet-food-secre... ). Most of the regions in the Blue Zones are high in veggies, low in meat, often with a bit of seafood, and virtually zero processed foods.

How you define a little meat really varies when going by "blue zones". Some might say 4-6oz a day, some might say 1-2x a week. The low amounts of meat and obtaining incomplete proteins with more narrow amino acid profiles is beneficial for health in the long term, largely due to mTor activation being avoided or reduced. The body evolved (it seems) to an extent, to struggle for certain nutrients (but that doesn't mean do without them entirely, but just periods of not having everything at once, constantly). This seems very apparent with studies into proteins. When it comes to other vitamins and minerals (electrolytes, vitamins, etc..) we seems to need those fairly constantly/consistently.

the ultimate way to not activate mTor or stimulate IGF-1, is to fast. Either do time-restricted eating where you eat in a 4-8 hour window every day, or periodically do multiple day fasts..

The timing of your eating, IMHO, is more important than how much meat or veggies you consume. If you ate one meal a day and had meat at that meal, even in large amounts, it'd be more benefitial than say... eating 3 meals a day and being fully vegan or vegetarian. How often you're eating seems to have a more negative effect on lifespan than, to some extent, what you're eating.

I don't avoid meat. I rely on greek yogurt, eggs 1-2x a week, 4-5oz of meat (mostly fish, low-fat chicken breasts without skin, and beef 1x a week), a variety of nuts (i prefer macademia nuts b/c they're low in omega6, low in oxylates and high in monosaturated fats, most other nuts are high in Omega6s and/or oxylates).

I probably eat at a midway point between what i should do for health and lifespan.

If you're more concerned with health span than lifespan then you really want to get about 1G of protein per KG in body weight.

If you're more concerned about lifespan, 0.5G per KG of body weight is more where you want to be.

If you went full carnivore, you'd probably feel absolutely amazing. Eating a lot of meat spurs on testosterone, increases fertility and reproductive capability, and all sorts of great stuff, but the trade off seems to be for lifespan.

You'll notice body builders often don't make it to 100 years old. But look at the Mediterranean, look at japan - fairly thin, active people - often with religious/community connections, who are eating mostly veggies, a little meat, and some seafood once in a while, they're the ones passing the 100 year mark more often.

Doing stuff like fasting, or eating a, lets call it a plant-based diet as opposed to vegetarian, (or both), doesn't feel so great. You can't perform at the gym like you usually would, for example.

The body is best, from a lifespan perspective and to a certain extent, a healthspan perspective, when it's exposed to hormetic stressors. These are little stressors that improve the over-all functioning of your body. Exercise is one. Sauna use is another. Cold exposure (showers, ice baths) is another.

But fasting is too, spurring on autophagy (which is the strongest anti-cancer process we have, internally) and all other great processes like the down regulation of IGF-1.

The body not quite having all the protein it needs, ALL THE TIME, is a beneficial stressor that works to increase lifespan as well. As far as I've read anyways.

Eating many vegetables are also hormetic stressors. Various phytonutrients are built by plants as reactions to when they are stressed, these phytonutrients produced under those conditions are some of the best substances we can eat. Like sulphorafane (from broccoli, broccoli sprouts, kale, cabbage, brussel sprouts, etc.)

- https://www.youtube.com/watch?v=zz4YVJ4aRfg - https://www.youtube.com/watch?v=-PNGxNzogOY

IMHO - i'd keep on with (grass fed/finished where applicable) meat, yogurt, nuts, a little whey from time to time, 4-5oz of meat a day, (free range or omega3+) eggs every once in a while. But at 40 years old and experiencing some health problems stemming from a mix of a lifetime of bad habits (drinking, smoking, sodas, fast food) and a bit of anxiety that clobbered me in adulthood.. i lean more towards longevity these days that i do in making sure i can lift at the gym and maximizing my athletic performance.

i don't care about what i look like anymore. I don't care about satisfying my ego at the gym anymore either. I just want to be happy and live to see my grandkids be born and maybe go through some pivotal things in elementary school before kicking the bucket.

I eat 2 meals a day 5 days a week

i fast 2-3 days a month, at the beginning of the month.

I eat "normally" for social purposes on the weekends.

I don't calorie count. I've found that based on WHAT i'm eating, calories don't matter much. I did Keto for 6 months and even eating tons of meat and hitting 3kcals a day, i was still losing weight when my carbs were under 20g a day.

But now I probably don't hit 2k cal a day and sometimes my weight fluctuates up 1-3 pounds or back down, here and there. And i exercise 5-6 days a week.

i know i ramble (ADHD) but i used to pack on 3k a day or more, and drink protein shakes and hit the gym and make sure i was getting lots of protein.

I've long abandoned that mentality. I stopped listening to fitness people and started listening to doctors and scientists.

Re: Soybean oil affects hypothalamus, causes genetic changes in mice: study (2020)

#349

Do not take this work seriously unless you are a male inbred mouse of the C57BL/6N persuasion. This is a classic N=1 study of one sex and one genome of mouse. As such this work is of almost no know relevance to other strains of mice, let alone to humanity. If you want an example of how mice dietary studies should be done then look to the National Institute on Aging and its Interventions Testing Program. They use both…

It's should be taken as a serious indication that further study is needed.

Re: Soybean oil affects hypothalamus, causes genetic changes in mice: study (2020)

#350
post #204

I used to eat sardines every day trying to get the health benefits of fatty fish. They were packed in soybean oil. I drank the oil too. With time I began to have bizarre mental issues that I finally tracked down to the sardines. Sardines packed in olive oil don’t cause this issue. That’s my anecdata to share.

Maybe that was oils in general? Eating too much cooking oil makes me feel like absolute crap mentally, regardless of type. Obviously the syndrome described in article is possible in your case, but the article sounds like a chronic accumulated damage thing, not an acute reaction just after eating.

The sentence "Sardines packed in olive oil don’t cause this issue." suggests that it's not.
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